DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt1 and LOC100493529

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	XP_002932169.1	Gene:	LOC100493529 / 100493529	-ID:	-	Length:	428	Species:	Xenopus tropicalis

Alignment Length:	430	Identity:	244/430 - (56%)
Similarity:	303/430 - (70%)	Gaps:	19/430 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 KAAEAASQRIAQVESTTRSATTEAQESTTTA------VPVIKKIEHVGEVVTEVIAERTGLPTWG 114
            |.|||.......:.::|.........||..|      ....:||:.  |::.::  .:..||.|.
Frog     7 KKAEAPPPETHTMPTSTEPPVVSQDNSTAVAGSGDKSADTFRKIQQ--ELMNQI--NKIPLPPWA 67

  Fly   115 VVAIIILVFLVVFGIIF-FCVRRFLKKRRTKDGKG---KKGVDMKSVQLLGSAYKEKVQPDMEE- 174
            ::||.::..|::....| .|.:...||::.|..||   |..::||.::..|....:....|.|.
Frog    68 LIAIAVVAGLLIITCCFCICKKCCCKKKKGKKEKGKGMKNALNMKDMKGSGGQNAKDDDDDAETG 132

  Fly   175 LTENAEEGDEEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEELPALDMGGTSDPYVKVYLLPD 239
            |||.  |..||:::.|:|||:|.|.|:|||.:|.:.|.:|||.|||||||||||||||||:.|||
Frog   133 LTEG--EDKEEEEKEEEKLGKLQFSLDYDFQNNQMQVGIIQATELPALDMGGTSDPYVKVFFLPD 195

  Fly   240 KKKKFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFSKHDQIGEVKVPLCTIDL 304
            ||||.|||||||||:|:|||||||| :||.:...|||..:|:|||||||||.|||||||:.|:||
Frog   196 KKKKHETKVHRKTLNPIFNETFTFK-IPYQELGGKTLCMSIYDFDRFSKHDIIGEVKVPMNTVDL 259

  Fly   305 AQTIEEWRDLVSVEGEGGQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIAI 369
            .|.|||||||.|.|.| ..|||||||.|||||||||||||.||||||||||||||||||||||.:
Frog   260 GQPIEEWRDLQSAEKE-EPEKLGDICISLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHL 323

  Fly   370 MQNGKRLKKKKTSIKKCTLNPYYNESFSFEVPFEQIQKICLVVTVVDYDRIGTSEPIGRCILGCM 434
            ||||||||||||::||.|||||:|||||||:|||||||:.:|:||:|||::|.:|.||:..:||.
Frog   324 MQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVVITVLDYDKLGKNEAIGKIFVGCN 388

  Fly   435 GTGTELRHWSDMLASPRRPIAQWHTLKDPEETDEILKNMK 474
            .:||||||||||||:|||||||||.||..||.|..|.:.|
Frog   389 ASGTELRHWSDMLANPRRPIAQWHPLKPEEEVDIALGSKK 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467	19/86 (22%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	89/123 (72%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	106/134 (79%)
LOC100493529	XP_002932169.1	C2A_Synaptotagmin-1-5-6-9-10	153..271	CDD:176031	85/118 (72%)
LOC100493529	XP_002932169.1	C2B_Synaptotagmin-1	280..415	CDD:176047	106/134 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	178	1.000	Domainoid score	I3492
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	470	1.000	Inparanoid score	I1481
OMA	1	1.010	-	-		QHG48342
OrthoDB	1	1.010	-	-		D394604at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	1	1.000	-	-		otm48349
Panther	1	1.100	-	-	LDO	PTHR10024
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4219
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.110