DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt1 and LOC100486361

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	XP_002931826.4	Gene:	LOC100486361 / 100486361	-ID:	-	Length:	959	Species:	Xenopus tropicalis

Alignment Length:	507	Identity:	116/507 - (22%)
Similarity:	213/507 - (42%)	Gaps:	97/507 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NAKSET---DAKPEAEPAPASEPAADLESVDQKLEETHHSKFREVDRQEQEVLAEKAAEA----- 60
            :.|.|:   :.|||.:..|.|.....:::|....|:...:..:...|.| :|:.....|:
Frog   480 SCKEESVTPEIKPEVKGTPYSNVQILIDTVTSDEEQGATASVKAAQRSE-DVVEHATCESEDGKS 543

  Fly    61 ---------ASQRIAQVESTTRS-----ATTEAQESTTTAVPVIKKIEHVGEV--VTEVIAERTG 109
                     .||.|.  .::.||     .:||......|....:.:.|...|:  .|..:...|.
Frog   544 LDGNVDSNPTSQAIG--VTSARSLVNIYTSTETYNKPQTLSHQLLEPERAKELSRSTPALLSETE 606

  Fly   110 LPTWGVVAIIILVFLVVFGIIFFCVRRFLKKRRTKDGKGKKGVDMKSVQLLGSAYKEKVQPDMEE 174
            ..|...::.                  .||:.|..........||.||..:.::.......|...
Frog   607 SDTASEISF------------------QLKRHRKTHSSDSNSSDMASVSSVSNSVLSVYSGDFGS 653

  Fly   175 LTENAEEGDEEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEELPALD-MGGTSDPYVKVYLLP 238
            :          |.|     |.:.|.|:||..:....::|.|.::|..:| ..|.||||||.||||
Frog   654 V----------DAQ-----GAVEFSLDYDEKNREFQISVSQCKDLAIVDEKKGRSDPYVKTYLLP 703

  Fly   239 DKKK--KFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFSKHDQIGEVKVPLCT 301
            ||.:  |.:|.|.|:|.:||:||...:|.......:.| |..:::..|...::..:||:::.|.:
Frog   704 DKARMGKRKTSVKRRTTNPVYNEVLRYKIEKMVLLIQK-LNLSVWHNDPLGRNSFLGEMEIDLTS 767

  Fly   302 IDLAQTIEEWRDLV--SVEGEGGQEKLGDICFSLRYV---------PTAGKLTVVILEAKNLKKM 355
            .|.:.|...|..|.  ||....|.:.||.:..|::|:         ||:|::.:.:.:.|:|.::
Frog   768 WDWSNTKSNWYPLKPRSVSAMNGVDHLGVMNLSIKYIPPGSLGPKHPTSGEVHIWVKDTKDLPQL 832

  Fly   356 DVGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFE-VPFEQIQKICLVVTVVDYDR 419
            ...|: |.:||..::.:..:...:||.:.|...||.:|.:..:: ...|.::..|:.:||.|:::
Frog   833 RPSGV-DSFVKCYVLPDTSKKSYQKTRVIKKDSNPVFNHTIVYDGFHTEDLRDACVELTVWDHEK 896

  Fly   420 IGTSEPIGRCILGCMGTG--------------TELRHWSDMLASPRRPIAQW 457
            : ::..:|...|| :|||              .|:..|.:|:::|.    :|
Frog   897 L-SNHFLGGIRLG-LGTGFSYGIAVDWMDSTQEEVAFWQEMMSTPN----EW 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467	26/154 (17%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	42/128 (33%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	35/156 (22%)
LOC100486361	XP_002931826.4	PHD_SF	13..>68	CDD:419867
		C2A_SLP-1_2	657..781	CDD:176039	42/129 (33%)
		C2B_SLP_1-2-3-4	795..950	CDD:175987	34/155 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910