DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt1 and tc2n

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	XP_002933250.4	Gene:	tc2n / 100485673	XenbaseID:	XB-GENE-983033	Length:	487	Species:	Xenopus tropicalis

Alignment Length:	355	Identity:	80/355 - (22%)
Similarity:	137/355 - (38%)	Gaps:	60/355 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 LKKRRTKDGKGKKGV---------------DMKSVQLLGSAYKEKVQPDMEELTENAEEGDEEDK 187
            |:..:..|..|..|.               .:.|::...|:.|:. |.....|......|||:|
Frog   158 LRSNKVTDSPGVTGTLYDFNGSPRNIQRYDSVSSIRSSNSSRKDS-QGSNRSLDTITLSGDEKD- 220

  Fly   188 QSEQKLGRLNFKLEYDFNSNSLAVTVIQAEELP-ALDMGGTSDPYVKVYLLPDKKKKFETKVHRK 251
                 .|||||||.|......:.:||::.::|. .:..|.....|:|..:...|...|::.....
Frog   221 -----FGRLNFKLRYIVAVEQIWITVVKIKDLSWPVSCGENPSIYIKGIITLPKAVPFKSSAKEG 280

  Fly   252 TLSPVFNETFTFKSLPYADAMNKTLVFAIFDF---DRFSKHDQIGEVKVPLCTIDLAQTIEE--- 310
            :|...|.|||.| ::.:.......|||.:...   .|...|          |:|.|....||
Frog   281 SLDTEFMETFVF-AIKHQSLQASRLVFKVLSLTPRKRTISH----------CSISLRDLSEEETD 334

  Fly   311 -WRDLVSVEGEGGQEKLGDICFSLRYVPTA-----GKLTVVILEAKNLKKMDVGGLSDPYVKIAI 369
             |.:||.      ..|: .:|.:...|.|.     .::.:.||:|:||.........:.:||:.:
Frog   335 HWLELVP------SSKV-TVCQAELQVGTCFQAINSRIQLQILKAQNLPNSSTPLSINFFVKVEM 392

  Fly   370 MQNGKRLKKKKTSIKKCT---LNPYYNESFSFEVPFEQIQKICLVVTVVDYDRIGTSEPIGRCIL 431
            ......|.||||.:.|.|   :|  :.|:..|.|..:: :.|..::.:.....:.....||:..:
Frog   393 FSTEGLLYKKKTRLLKVTNGQVN--WGETMIFPVTLKE-EGINFLIKLYSRSSVRRKHFIGQVWI 454

  Fly   432 GCMGTGTELR-HWSDMLASPRRPIAQWHTL 460
            ......:|.. .|:|.:..|.:.:.:||.|
Frog   455 SSDSNSSEAADQWTDTIQHPEKVVTKWHKL 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	34/131 (26%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	31/144 (22%)
tc2n	XP_002933250.4	C2A_Tac2-N	237..339	CDD:176066	25/112 (22%)
tc2n	XP_002933250.4	C2B_Tac2-N	350..484	CDD:176074	29/136 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910