DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt1 and syt8

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	XP_012815834.1	Gene:	syt8 / 100037878	XenbaseID:	XB-GENE-978920	Length:	396	Species:	Xenopus tropicalis

Alignment Length:	419	Identity:	190/419 - (45%)
Similarity:	267/419 - (63%)	Gaps:	40/419 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 IAQVESTTRSATTEAQESTTTAVPVIKKIEHVGEVVTEVIAERTGLPTWGVVAI------IILVF 123
            :|:..:.|.:|||  ..:|||..|         |...:.|..:..||.|.:.|:      |||:|
Frog     1 MARNSTNTTAATT--IYATTTKEP---------ESWIDSILNQIPLPRWAIYALAGLALFIILLF 54

  Fly   124 LVVFGIIFFCVRRFLKKRRTKDGKGKKGVDMKSVQLLGSAYKEKVQPDMEELTENAEEGDEEDKQ 188
            ::   .|..|..:..|.::.||    |.:||..|.  |:.....|||.    ..|.::|::.:.:
Frog    55 II---CICCCCCKSKKNKKKKD----KKIDMDKVP--GNLTTHLVQPG----AGNLQKGEKVEYR 106

  Fly   189 SEQKLGRLNFKLEYDFNSNSLAVTVIQAEELPALDMGGTSDPYVKVYLLPDKKKKFETKVHRKTL 253
                 ||:.:.|||:|.:..|.|.|.||..|.|:|:|||||||..||:..|.:|||||||:||||
Frog   107 -----GRVQYSLEYNFQTEELTVGVKQAAALKAMDLGGTSDPYAIVYVTNDTRKKFETKVNRKTL 166

  Fly   254 SPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFSKHDQIGEVKVPLCTIDLAQTIEEWRDLVSVE 318
            :|||||:|.|| :...:....|.|..||||:||.|||.|||:.:||..::|...||:|:|| ...
Frog   167 NPVFNESFVFK-VTQEEVPRTTAVVQIFDFNRFLKHDVIGEMVIPLGEVNLQHVIEDWKDL-GPA 229

  Fly   319 GEGGQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIAIMQNGKRLKKKKTSI 383
            |:...|.||||||||||||::||||::||||||||:||..|.||||||:.:..|.|:.|:|||::
Frog   230 GKTEHEHLGDICFSLRYVPSSGKLTIIILEAKNLKRMDSDGFSDPYVKVHLALNRKKWKRKKTAV 294

  Fly   384 KKCTLNPYYNESFSFEVPFEQIQKICLVVTVVDYDRIGTSEPIGRCILGCMGTGTELRHWSDMLA 448
            ||.||.||:||||:|:|..||::.:.|:::|.|:|::|.:|.||:..|||..:|..|||||||||
Frog   295 KKSTLKPYFNESFTFDVSLEQMKNLDLIISVWDHDKVGKNEQIGKLFLGCRASGNALRHWSDMLA 359

  Fly   449 SPRRPIAQWHTLKDPEETDEIL---KNMK 474
            .|||||||||.|::.:|.|::|   :|:|
Frog   360 HPRRPIAQWHKLQEADEVDKVLELKRNLK 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467	21/76 (28%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	65/123 (53%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	83/134 (62%)
syt8	XP_012815834.1	C2A_Synaptotagmin-1-5-6-9-10	105..228	CDD:176031	65/129 (50%)
syt8	XP_012815834.1	C2B_Synaptotagmin-1	237..372	CDD:176047	83/134 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	44	1.000	Domainoid score	I12087
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D394604at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10024
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.020