DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt1 and syt1b

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001082930.1	Gene:	syt1b / 100034471	ZFINID:	ZDB-GENE-060503-166	Length:	388	Species:	Danio rerio

Alignment Length:	434	Identity:	220/434 - (50%)
Similarity:	281/434 - (64%)	Gaps:	59/434 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 QEQEVLAEKAAEAAS--QRIAQVESTTRSATTEAQESTTTAVPVIKKIEHVGEVVTEVIAERTGL 110
            ::...||..::..||  |:.:::..:|.|:.|.....||||..::..|.  .:.:.|:  .:..|
Zfish     3 EDDAPLAASSSSPASLAQKESKIPGSTISSPTAVHPQTTTADSLVHSIR--SKFLNEL--HKVPL 63

  Fly   111 PTWGVVAIIILVFLVVFGIIFFCV----RRFLKKRRTKDGK---GKKGVDMKSVQLLGSAYKEKV 168
            |:|...|   |.|:.||.::..|:    :...||::.|.||   .|..::|.:|:..|:  |:.|
Zfish    64 PSWATAA---LGFITVFIVLSCCLCIFRKMIFKKKKEKGGKEKNEKNDINMSNVKEEGT--KQAV 123

  Fly   169 QPDMEELTENAEEGDEEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEELPALDMGGTSDPYVK 233
            ....:   .:|:|.|.|.|:: ||||:|.:.|:|:|..::|.|.||:||.|.|:||.||||||||
Zfish   124 HHTTD---SDAKEEDSESKEA-QKLGKLLYTLDYNFTDSTLIVGVIRAEGLAAMDMSGTSDPYVK 184

  Fly   234 VYLLPDKKKKFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFSKHDQIGEVKVP 298
            ||||||||||||||||||||.|.|||.|||| :|||:...||||..::|||||||||.||:|::.
Zfish   185 VYLLPDKKKKFETKVHRKTLEPTFNEHFTFK-VPYAELGGKTLVMTVYDFDRFSKHDAIGDVRLQ 248

  Fly   299 LCTIDLAQTIEEWRDLVSVEGEGGQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDP 363
            :..:|.:...||||||...|.| .||:|||||.||||||||||||||:|||||||||||||||||
Zfish   249 MNKVDFSHLTEEWRDLQKAEKE-EQERLGDICLSLRYVPTAGKLTVVVLEAKNLKKMDVGGLSDP 312

  Fly   364 YVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFEVPFEQIQKICLVVTVVDYDRIGTSEPIGR 428
            ||||.:||||||||||||:|||.|||||||||||||||.||||
Zfish   313 YVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPSEQIQ---------------------- 355

  Fly   429 CILGCMGTGTELRHWSDMLASPRRPIAQWHTLKDPEETD-EILK 471
                        ||||||||:|||||||||.||..|:.| |::|
Zfish   356 ------------RHWSDMLANPRRPIAQWHALKPEEDVDAELIK 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467	23/93 (25%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	79/123 (64%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	91/134 (68%)
syt1b	NP_001082930.1	C2A_Synaptotagmin-1-5-6-9-10	143..266	CDD:176031	79/123 (64%)
syt1b	NP_001082930.1	C2	275..376	CDD:301316	91/134 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	162	1.000	Domainoid score	I3947
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	459	1.000	Inparanoid score	I1541
OMA	1	1.010	-	-		QHG48342
OrthoDB	1	1.010	-	-		D394604at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10024
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.940