DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt1 and syt3

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	XP_005164031.1	Gene:	syt3 / 100000615	ZFINID:	ZDB-GENE-090601-1	Length:	566	Species:	Danio rerio

Alignment Length:	309	Identity:	152/309 - (49%)
Similarity:	210/309 - (67%)	Gaps:	14/309 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 KSVQLLGSAYKEKVQPDMEELTENAEEGDEEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEEL 219
            ||.||....   :::|::..|    .:||:.|.:.....|:::|.|.|.||:..|.|.:::|.:|
Zfish   239 KSEQLTSIG---QIKPELYRL----RQGDQGDGKQGNNCGKISFLLRYAFNTEQLVVKILKALDL 296

  Fly   220 PALDMGGTSDPYVKVYLLPDKKKKFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFD 284
            ||.|..|.||||||:|||||:||||:||||||||:|||||||.| .:|.|:...:.|.|:::|||
Zfish   297 PAKDANGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPVFNETFQF-GVPLAELHARKLHFSVYDFD 360

  Fly   285 RFSKHDQIGEVKVPLCTIDLAQTIEE---WRDLVSVEGEGGQEKLGDICFSLRYVPTAGKLTVVI 346
            |||:||.||:|.|. ..:|.::...|   |||:  |||...:..||::.|||.|:||||:|||.|
Zfish   361 RFSRHDLIGQVVVD-NLLDFSEGTGEKPIWRDI--VEGTAEKADLGELNFSLCYLPTAGRLTVTI 422

  Fly   347 LEAKNLKKMDVGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFEVPFEQIQKICLV 411
            ::|.|||.||:.|.||||||.:::..|:||||:||||||.||||.|||:..|::|.|.|:.:.|:
Zfish   423 IKATNLKAMDLTGFSDPYVKASLVCEGRRLKKRKTSIKKNTLNPTYNEALVFDIPNENIESVSLI 487

  Fly   412 VTVVDYDRIGTSEPIGRCILGCMGTGTELRHWSDMLASPRRPIAQWHTL 460
            :.|:|||.||.:|.||.|.:|....|....||:.|||:||:||..||.|
Zfish   488 IAVMDYDCIGHNEVIGMCRMGSDADGPGREHWTAMLANPRKPIEHWHQL 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	66/126 (52%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	74/135 (55%)
syt3	XP_005164031.1	C2A_Synaptotagmin-1-5-6-9-10	269..394	CDD:176031	66/128 (52%)
syt3	XP_005164031.1	C2B_Synaptotagmin-3-5-6-9-10	403..536	CDD:176048	72/132 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D394604at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820