DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt1 and syt17

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	XP_001922508.4	Gene:	syt17 / 100000374	ZFINID:	ZDB-GENE-090527-1	Length:	474	Species:	Danio rerio

Alignment Length:	318	Identity:	123/318 - (38%)
Similarity:	191/318 - (60%)	Gaps:	16/318 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 YKEKVQPDMEELTENAEEGD---EEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEELP----- 220
            |..|::|.:..|...:::.|   :|:.....:||.|:|..:||..:..|.|.||:|.:||
Zfish   153 YFRKLEPHLYSLDSCSDDVDSLTDEEILMRYQLGMLHFSTQYDLINAHLIVRVIEARDLPPPVTC 217

  Fly   221 ---ALDMGGTSDPYVKVYLLPDKKKKFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFD 282
               ..|| ..|:||||:.||||.|...:|.|.|||.:|||.|.||| .||:.:|..:||:.::.|
Zfish   218 DGARQDM-AHSNPYVKMSLLPDNKNSRQTGVKRKTQNPVFEERFTF-DLPFLEAQRRTLLLSVVD 280

  Fly   283 FDRFSKHDQIGEVKVPLCTIDLAQTIEEWRDLVSVEGEGGQEKLGDICFSLRYVPTAGKLTVVIL 347
            ||:||:|..||:|.:||..:||.:....|:.|  |.....:.:||::..||.|:|:||:|.|.|:
Zfish   281 FDKFSRHCVIGKVALPLSEVDLVKGGHWWKAL--VPSSQNEVELGELLLSLNYLPSAGRLNVDII 343

  Fly   348 EAKNLKKMDVGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFEVPFEQIQKICLVV 412
            .||.|.:.|:...|||:||:.::...|.:|.||||..:.|::|.|||||||.||.|.:.::.||:
Zfish   344 RAKQLLQTDMCQGSDPFVKVQLVTGLKLMKSKKTSCMRGTIDPCYNESFSFRVPQEDLCEVSLVL 408

  Fly   413 TVVDYDRIGTSEPIGRCILGCMGTG-TELRHWSDMLASPRRPIAQWHTLKDPEETDEI 469
            ||..::...:::.:||.::|...:| .|..||..:|:|.|.|:.|||:|:...|.|.:
Zfish   409 TVYGHNVKSSNDFVGRIVIGQFSSGPQETTHWRRLLSSQRTPVEQWHSLRSRAECDRV 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	57/131 (44%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	56/135 (41%)
syt17	XP_001922508.4	C2A_Synaptotagmin-15-17	186..314	CDD:176036	56/131 (43%)
syt17	XP_001922508.4	C2B_Synaptotagmin-17	323..457	CDD:176055	55/133 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D394604at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820