DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aph-1 and APH1B

DIOPT Version :9

Sequence 1:	NP_001259963.1	Gene:	aph-1 / 33467	FlyBaseID:	FBgn0031458	Length:	238	Species:	Drosophila melanogaster
Sequence 2:	NP_112591.2	Gene:	APH1B / 83464	HGNCID:	24080	Length:	257	Species:	Homo sapiens

Alignment Length:	248	Identity:	111/248 - (44%)
Similarity:	153/248 - (61%)	Gaps:	13/248 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTLPEFFGCTFIAFGPPFALFVFTIANDPVRIIILIAAAFFWLLSLLISSL-WY---ALIPLKE- 60
            ||...||||.||||||..||:|||||.:|:|||.|||.|||||:||||||| |:   .:|..|:
Human     1 MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVIIDNKDG 65

  Fly    61 -----FLAFGVVFSVCFQEAFRYIIYRILRSTEQGLHAVAEDTRVTDNKHILAYVSGLGFGIISG 120
                 .|.||...||..||.||:..|::|:...:||.:: .......:..:|||||||||||:||
Human    66 PTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSI-NPGETAPSMRLLAYVSGLGFGIMSG 129

  Fly   121 MFALVNVLADMSGPGTMGLKGGTELFFVTSAAQALSIILLHTFWSVIFFNAFDTNNYIHIGYVVF 185
            :|:.||.|:|..||||:|:.|.:..||:.||...|.|||||.||.::||:..:...:..:..|:.
Human   130 VFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFDGCEKKKWGILLIVLL 194

  Fly   186 SHLFVSLITLLNANELYTTTLLINYLVTILTGVLAFRVAGGTSRSFRKFITCQ 238
            :||.||..|.:::  .|...|...:::.:|.|..||..|||:.||.:..:.||
Human   195 THLLVSAQTFISS--YYGINLASAFIILVLMGTWAFLAAGGSCRSLKLCLLCQ 245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aph-1	NP_001259963.1	Aph-1	2..225	CDD:283708	103/232 (44%)
APH1B	NP_112591.2	Aph-1	3..232	CDD:310594	102/231 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147794
Domainoid	1	1.000	220	1.000	Domainoid score	I2627
eggNOG	1	0.900	-	-		E1_KOG3972
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	224	1.000	Inparanoid score	I3522
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55474
OrthoDB	1	1.010	-	-		D1085102at2759
OrthoFinder	1	1.000	-	-		FOG0003244
OrthoInspector	1	1.000	-	-		otm40298
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12889
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4469
SonicParanoid	1	1.000	-	-		X3174
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.900