DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aph-1 and aph1a

DIOPT Version :9

Sequence 1:	NP_001259963.1	Gene:	aph-1 / 33467	FlyBaseID:	FBgn0031458	Length:	238	Species:	Drosophila melanogaster
Sequence 2:	XP_012808647.1	Gene:	aph1a / 548560	XenbaseID:	XB-GENE-921428	Length:	265	Species:	Xenopus tropicalis

Alignment Length:	248	Identity:	108/248 - (43%)
Similarity:	160/248 - (64%)	Gaps:	12/248 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTLPEFFGCTFIAFGPPFALFVFTIANDPVRIIILIAAAFFWLLSLLISSL-WYALIPLKE---- 60
            |.|..||||||:||||..:||:.|||.||:::|||:|.:||||:|:|:||| |:..:.:..
Frog     1 MALAVFFGCTFVAFGPALSLFILTIAVDPLKVIILVAGSFFWLVSVLLSSLIWFISVQISNKNDA 65

  Fly    61 -----FLAFGVVFSVCFQEAFRYIIYRILRSTEQGLHAVAEDTRVTDNKHILAYVSGLGFGIISG 120
                 .|.||...||..||.|||..||:|:..::||..::||.|...:...:|||||..||||||
Frog    66 NLQYGLLIFGAAVSVLLQETFRYAYYRLLKKADEGLATISEDGRSPISIQQMAYVSGFSFGIISG 130

  Fly   121 MFALVNVLADMSGPGTMGLKGGTELFFVTSAAQALSIILLHTFWSVIFFNAFDTNNYIHIGYVVF 185
            :|:::|:|||..|||.:|:.|.::.:|:|||...::|:.|||||.::||.|.:....:||..||.
Frog   131 VFSVINILADAIGPGIVGVHGDSQYYFLTSAFLTMAIVFLHTFWGIVFFAACEKRKPLHIIGVVL 195

  Fly   186 SHLFVSLITLLNANELYTTTLLINYLVTILTGVLAFRVAGGTSRSFRKFITCQ 238
            |||..|.:|.|  |.:|..:|:..|::|:...:.||..|||..::.||.:.|:
Frog   196 SHLVASGLTFL--NPMYEASLIPIYIITLGMALWAFVAAGGNYQNIRKCLACR 246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aph-1	NP_001259963.1	Aph-1	2..225	CDD:283708	101/232 (44%)
aph1a	XP_012808647.1	Aph-1	3..233	CDD:368748	101/231 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	207	1.000	Domainoid score	I2832
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H9345
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3508
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1085102at2759
OrthoFinder	1	1.000	-	-		FOG0003244
OrthoInspector	1	1.000	-	-		oto102262
Panther	1	1.100	-	-	O	PTHR12889
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4469
SonicParanoid	1	1.000	-	-		X3174
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.190