Protein Alignment aph-1 and APH1A

DIOPT Version :9

• Sequence 1: NP_001259963.1
• Gene: aph-1 / 33467
• FlyBaseID: FBgn0031458
• Length: 238
• Species: Drosophila melanogaster
• Sequence 2: XP_024303223.1
• Gene: APH1A / 51107
• HGNCID: 29509
• Length: 316
• Species: Homo sapiens
• Alignment Length: 294
• Identity: 114/294 - (38%)
• Similarity: 163/294 - (55%)
• Gaps: 63/294 - (21%)

  Fly     6 FFGCTFIAFGPPFALFVFTIANDPVRIIILIAAAFFWLLSLLISS-LWYALIPLKE--------- 60
            ||||||:||||.||||:.|:|.||:|:|||:|.|||||:|||::| :|:.|:.:.:
Human     6 FFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVTDRSDARLQYG 70

  Fly    61 FLAFGVVFSVCFQEAFRYIIYRILRSTEQGLHAVAEDTRVTDNKHILAYVSGLGFGIISGMFALV 125
            .|.||...||..||.||:..|::|:..::||.:::||.|...:...:||||||.||||||:|:::
Human    71 LLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYVSGLSFGIISGVFSVI 135

  Fly   126 NVLADMSGPGTMGLKGGTELFFVTS---------------------------------------- 150
            |:|||..|||.:|:.|.:..:|:||
Human   136 NILADALGPGVVGIHGDSPYYFLTSGKIHLLSSLYPPSILVPDLIYWPSLRDFFGSTSQEPGRRS 200

  Fly   151 -----------AAQALSIILLHTFWSVIFFNAFDTNNYIHIGYVVFSHLFVSLITLLNANELYTT 204
                       |....:||||||||.|:||:|.:...|..:|.||.|||..|.:|.|  |..|..
Human   201 GMYLLPISLPAAFLTAAIILLHTFWGVVFFDACERRRYWALGLVVGSHLLTSGLTFL--NPWYEA 263

  Fly   205 TLLINYLVTILTGVLAFRVAGGTSRSFRKFITCQ 238
            :||..|.||:..|:.||..|||:.||.::.:.|:
Human   264 SLLPIYAVTVSMGLWAFITAGGSLRSIQRSLLCR 297

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aph-1	NP_001259963.1	Aph-1	2..225	CDD:283708	108/279 (39%)
APH1A	XP_024303223.1	Aph-1	3..284	CDD:310594	108/279 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147795
Domainoid	1	1.000	220	1.000	Domainoid score	I2627
eggNOG	1	0.900	-	-		E1_KOG3972
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9345
Inparanoid	1	1.050	224	1.000	Inparanoid score	I3522
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55474
OrthoDB	1	1.010	-	-		D1085102at2759
OrthoFinder	1	1.000	-	-		FOG0003244
OrthoInspector	1	1.000	-	-		otm40298
orthoMCL	1	0.900	-	-		OOG6_104863
Panther	1	1.100	-	-	O	PTHR12889
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4469
SonicParanoid	1	1.000	-	-		X3174
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800