DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aph-1 and aph1b

DIOPT Version :9

Sequence 1:	NP_001259963.1	Gene:	aph-1 / 33467	FlyBaseID:	FBgn0031458	Length:	238	Species:	Drosophila melanogaster
Sequence 2:	NP_956409.1	Gene:	aph1b / 386808	ZFINID:	ZDB-GENE-031118-31	Length:	258	Species:	Danio rerio

Alignment Length:	248	Identity:	117/248 - (47%)
Similarity:	167/248 - (67%)	Gaps:	12/248 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTLPEFFGCTFIAFGPPFALFVFTIANDPVRIIILIAAAFFWLLSLLISSL-WYALIPL------ 58
            ||:..|||||||||||..|||:||||.||:|:|.|||.|||||:|||:||| |:..:.:
Zfish     1 MTVAVFFGCTFIAFGPAIALFMFTIARDPLRVIFLIAGAFFWLVSLLLSSLVWFITVQISNKNSA 65

  Fly    59 ---KEFLAFGVVFSVCFQEAFRYIIYRILRSTEQGLHAVAEDTRVTDNKHILAYVSGLGFGIISG 120
               :..|.||||.||..||||||..||:|:...:||.|::::..:..:...||||||||||.:||
Zfish    66 TQQRGLLIFGVVLSVLLQEAFRYGYYRLLKKANEGLLALSQEDTMPISMRQLAYVSGLGFGFMSG 130

  Fly   121 MFALVNVLADMSGPGTMGLKGGTELFFVTSAAQALSIILLHTFWSVIFFNAFDTNNYIHIGYVVF 185
            .|::||:|:|..||||:|:.|.::.:|::||...|:|||||.||.|:||.|.:...:..:|.||.
Zfish   131 AFSVVNILSDSLGPGTVGIHGESQHYFISSAFMTLAIILLHMFWGVVFFEACERQRWWALGAVVA 195

  Fly   186 SHLFVSLITLLNANELYTTTLLINYLVTILTGVLAFRVAGGTSRSFRKFITCQ 238
            |||.||.:|.:|.:  |..:|:..|::..:..|.|:..|||:.|:.:..:||:
Zfish   196 SHLVVSCLTFVNPH--YQGSLIPTYIILSVMAVWAYLCAGGSLRNLKLCLTCK 246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aph-1	NP_001259963.1	Aph-1	2..225	CDD:283708	110/232 (47%)
aph1b	NP_956409.1	Aph-1	2..233	CDD:283708	110/232 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581639
Domainoid	1	1.000	220	1.000	Domainoid score	I2561
eggNOG	1	0.900	-	-		E1_KOG3972
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9345
Inparanoid	1	1.050	227	1.000	Inparanoid score	I3457
OMA	1	1.010	-	-		QHG55474
OrthoDB	1	1.010	-	-		D1085102at2759
OrthoFinder	1	1.000	-	-		FOG0003244
OrthoInspector	1	1.000	-	-		otm25633
orthoMCL	1	0.900	-	-		OOG6_104863
Panther	1	1.100	-	-	O	PTHR12889
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4469
SonicParanoid	1	1.000	-	-		X3174
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800