DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aph-1 and Aph1b

DIOPT Version :9

Sequence 1:	NP_001259963.1	Gene:	aph-1 / 33467	FlyBaseID:	FBgn0031458	Length:	238	Species:	Drosophila melanogaster
Sequence 2:	NP_001040555.1	Gene:	Aph1b / 300802	RGDID:	1562468	Length:	257	Species:	Rattus norvegicus

Alignment Length:	249	Identity:	116/249 - (46%)
Similarity:	166/249 - (66%)	Gaps:	15/249 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTLPEFFGCTFIAFGPPFALFVFTIANDPVRIIILIAAAFFWLLSLLISSLWYALI--------- 56
            ||.|.||||.||||||..||::||||.||:|:|.|||.|||||:|||:||:::.|:
  Rat     1 MTAPVFFGCAFIAFGPALALYLFTIATDPLRVIFLIAGAFFWLVSLLLSSVFWFLVRVITDNRDG 65

  Fly    57 PLKEF-LAFGVVFSVCFQEAFRYIIYRILRSTEQGLHAV-AEDTRVTDNKHILAYVSGLGFGIIS 119
            |::.: |.|||:.|||.||.||...||:|:...:||.:: .|:|  ..:..:|||||||||||:|
  Rat    66 PVQNYLLIFGVLLSVCIQELFRLAYYRLLKKASEGLKSINPEET--APSMRLLAYVSGLGFGIMS 128

  Fly   120 GMFALVNVLADMSGPGTMGLKGGTELFFVTSAAQALSIILLHTFWSVIFFNAFDTNNYIHIGYVV 184
            |:|:.||.|::..||||:|:.|.:..||:.||...|.||:||.||.::||:..:.|.:..:..|:
  Rat   129 GVFSFVNTLSNALGPGTVGIHGDSPQFFLNSAFMTLVIIMLHVFWGIVFFDGCEKNKWYILLTVL 193

  Fly   185 FSHLFVSLITLLNANELYTTTLLINYLVTILTGVLAFRVAGGTSRSFRKFITCQ 238
            .:||.||..|||:.:  |...|:..|::.:|.|:.||.||||:.||.:..:.||
  Rat   194 LTHLLVSTQTLLSPH--YEVNLVTAYIIMVLMGIWAFCVAGGSRRSLKLCLLCQ 245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aph-1	NP_001259963.1	Aph-1	2..225	CDD:283708	108/233 (46%)
Aph1b	NP_001040555.1	Aph-1	2..232	CDD:283708	108/233 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341652
Domainoid	1	1.000	220	1.000	Domainoid score	I2536
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	225	1.000	Inparanoid score	I3413
OMA	1	1.010	-	-		QHG55474
OrthoDB	1	1.010	-	-		D1085102at2759
OrthoFinder	1	1.000	-	-		FOG0003244
OrthoInspector	1	1.000	-	-		otm44426
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12889
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3174
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.010