DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aph-1 and Aph1b

DIOPT Version :9

Sequence 1:	NP_001259963.1	Gene:	aph-1 / 33467	FlyBaseID:	FBgn0031458	Length:	238	Species:	Drosophila melanogaster
Sequence 2:	XP_006510985.1	Gene:	Aph1b / 208117	MGIID:	3522097	Length:	304	Species:	Mus musculus

Alignment Length:	294	Identity:	116/294 - (39%)
Similarity:	164/294 - (55%)	Gaps:	58/294 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTLPEFFGCTFIAFGPPFALFVFTIANDPVRIIILIAAAFFWLLSLLISSLWYALI--------- 56
            ||...||||.||||||..||:|||||.||:|:|.|||.|||||:|||:||:::.|:
Mouse     1 MTAAVFFGCAFIAFGPALALYVFTIATDPLRVIFLIAGAFFWLVSLLLSSVFWFLVRVITDNRDG 65

  Fly    57 PLKEF-LAFGVVFSVCFQEAFRYIIYRIL----------RSTEQGLH-AVAEDTRVTDNKHI--- 106
            |::.: |.|||:.|||.||.||...|::|          |..|.|.. :.|.:...|::::|
Mouse    66 PVQNYLLIFGVLLSVCIQELFRLAYYKLLKELKNLGSSMRKREGGTRMSAATEENTTESQYIGDK 130

  Fly   107 --------------------------------LAYVSGLGFGIISGMFALVNVLADMSGPGTMGL 139
                                            |||||||||||:||:|:.||.|::..||||:|:
Mouse   131 DLRLWEVQNSKRKASEGLKSINPEETAPSMRLLAYVSGLGFGIMSGVFSFVNTLSNSLGPGTVGI 195

  Fly   140 KGGTELFFVTSAAQALSIILLHTFWSVIFFNAFDTNNYIHIGYVVFSHLFVSLITLLNANELYTT 204
            .|.:..||:.||...|.:|:||.||.|:||:..:.|.:..:..|:.:||.||..|.|  :..|..
Mouse   196 HGDSPQFFLNSAFMTLVVIMLHVFWGVVFFDGCEKNKWYTLLTVLLTHLVVSTQTFL--SPYYEV 258

  Fly   205 TLLINYLVTILTGVLAFRVAGGTSRSFRKFITCQ 238
            .|:..|::.:|.|:.||.||||:.||.:..:.||
Mouse   259 NLVTAYIIMVLMGIWAFYVAGGSCRSLKLCLLCQ 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aph-1	NP_001259963.1	Aph-1	2..225	CDD:283708	108/278 (39%)
Aph1b	XP_006510985.1	Aph-1	3..279	CDD:368748	107/277 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837875
Domainoid	1	1.000	219	1.000	Domainoid score	I2626
eggNOG	1	0.900	-	-		E1_KOG3972
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	225	1.000	Inparanoid score	I3487
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55474
OrthoDB	1	1.010	-	-		D1085102at2759
OrthoFinder	1	1.000	-	-		FOG0003244
OrthoInspector	1	1.000	-	-		otm42364
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12889
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4469
SonicParanoid	1	1.000	-	-		X3174
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.900