DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Snx21 and Snx21

DIOPT Version :9

Sequence 1:	NP_608709.1	Gene:	Snx21 / 33466	FlyBaseID:	FBgn0031457	Length:	326	Species:	Drosophila melanogaster
Sequence 2:	XP_030102304.1	Gene:	Snx21 / 101113	MGIID:	1917729	Length:	372	Species:	Mus musculus

Alignment Length:	344	Identity:	96/344 - (27%)
Similarity:	142/344 - (41%)	Gaps:	51/344 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 MAKRLHHQPTF---DGDPPGPDE-----LDSP-----AIEAAALDIPPPESDKALQ------KGV 52
            ::.||....:|   :.||...||     ||||     |....|...|||:..::.|      :..
Mouse    44 LSSRLSGTLSFTSAEDDPDDEDEDDEAGLDSPPSGDGASGEDAERSPPPDGQRSSQLLARQLQDF 108

  Fly    53 WERATSAEYKPTTDGSTVLRFDILLAHIM--PPDGEDVKIKRFVV------YELTVKQDGATEDT 109
            |:::.:      |.....|.|::..|:::  ||.    |...:|:      |.|.|...| ..|.
Mouse   109 WKKSRN------TLVPQRLLFEVTSANVVKDPPS----KYVAWVISEEPQLYTLAVMGPG-PPDR 162

  Fly   110 QPAKIERRYTDFRELYLGLKRQHPAEMANKYFPAKVLMGNFKSELIGERSAAFEAFLTYVASQAM 174
            |||:|.|||:||..|:..|:||....|:...||.|.|..||.:|.|..||.|||.||.::.:...
Mouse   163 QPAQISRRYSDFERLHRNLQRQFRGPMSAISFPRKRLRRNFTAETIARRSRAFEQFLGHLQAVPE 227

  Fly   175 LRDSEYFLRFLQHDELTRACQFLDERRNEMAIPILENCFRLLNKI--YMNRSRPVLLILCRLVAA 237
            ||.:.....|....||.||...........|:.:..|.::|..::  .....|| ||.|..| |.
Mouse   228 LRQAPDLQDFFVLPELRRAQSLTCTGLYREALALWANAWQLQTQLGTPSGPDRP-LLTLAGL-AV 290

  Fly   238 C---TSSPVPHHAAERWALLALSRFETLCDIDLLPLYIPLLHTCAHLWWQRGQDQKPITDRLTDM 299
            |   ...|....|....||      :.|.|....|...|.|.....|.|:.|.|::....:|..:
Mouse   291 CHQELEDPGEARACSEKAL------QLLGDKRPHPFLAPFLEAHVRLSWRLGLDKRQSEAQLQAL 349

  Fly   300 SKQGINTANTESLMQAIHK 318
            .:.|:.:....||.:.:.|
Mouse   350 QEAGLTSTPPPSLKELLIK 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx21	NP_608709.1	PX_SNX20_21_like	71..188	CDD:132812	44/124 (35%)
Snx21	XP_030102304.1	PX_domain	121..241	CDD:383026	43/125 (34%)
		TPR_12	243..312	CDD:315987	18/73 (25%)
		TPR repeat	243..267	CDD:276809	5/25 (20%)
		TPR repeat	280..311	CDD:276809	6/30 (20%)
		TPR repeat	325..352	CDD:276809	5/26 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850189
Domainoid	1	1.000	64	1.000	Domainoid score	I10090
eggNOG	1	0.900	-	-		E1_KOG2101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H43132
Inparanoid	1	1.050	81	1.000	Inparanoid score	I5189
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004256
OrthoInspector	1	1.000	-	-		otm42651
orthoMCL	1	0.900	-	-		OOG6_109685
Panther	1	1.100	-	-	LDO	PTHR20939
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5585
SonicParanoid	1	1.000	-	-		X6082
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.780