DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Snx21 and Snx21

DIOPT Version :9

Sequence 1:	NP_608709.1	Gene:	Snx21 / 33466	FlyBaseID:	FBgn0031457	Length:	326	Species:	Drosophila melanogaster
Sequence 2:	XP_008760780.1	Gene:	Snx21 / 100362940	RGDID:	2323753	Length:	363	Species:	Rattus norvegicus

Alignment Length:	342	Identity:	95/342 - (27%)
Similarity:	135/342 - (39%)	Gaps:	56/342 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 MAKRLHHQPTFDGDPPGPDELDSPAIEAAALDIPPPESDKALQKGVWERATSAEYKPTTDG---- 67
            ::.||....:|......|||.|..  :.|.||.||        .|.......||..|..||
  Rat    44 LSSRLSGTLSFTSAEDDPDEEDED--DEAGLDSPP--------SGDGTSGEDAERSPPPDGQRSS 98

  Fly    68 ---------------STV----LRFDILLAHIM--PPDGEDVKIKRFVVYELTVKQDGATEDTQP 111
                           :|:    |.|::..|:::  ||       .::|:|.|.|...| ..|.||
  Rat    99 QLLARQLQDFWKKSRNTLVPQRLLFEVTSANVVKDPP-------SKYVLYTLAVMGPG-PPDRQP 155

  Fly   112 AKIERRYTDFRELYLGLKRQHPAEMANKYFPAKVLMGNFKSELIGERSAAFEAFLTYVASQAMLR 176
            |:|.|||:||..|:..|:||....|:...||.|.|..||.:|.|..||.|||.||.::.:...||
  Rat   156 AQISRRYSDFERLHRNLQRQFRGPMSAISFPRKRLRRNFTAETIARRSRAFEQFLGHLQAVPELR 220

  Fly   177 DSEYFLRFLQHDELTRACQFLDERRNEMAIPILENCFRLLNKI--YMNRSRPVLLILCRLVAAC- 238
            .:.....|....||.||...........|:.:..|.::|..::  .....|| ||.|..| |.|
  Rat   221 QAPELQDFFVLPELRRAQSLTCTGLYREALALWANAWQLQTQLGTPSGPDRP-LLTLAGL-AVCH 283

  Fly   239 --TSSPVPHHAAERWALLALSRFETLCDIDLLPLYIPLLHTCAHLWWQRGQDQKPITDRLTDMSK 301
              ...|....|....||      :.|.|....|...|.|.....|.|:.|.|::....:|..:.:
  Rat   284 QELEDPGEARACSEKAL------QLLGDKRPHPFLAPFLEAHVRLSWRLGLDKRQSEAQLQALQE 342

  Fly   302 QGINTANTESLMQAIHK 318
            .|:......||.:.:.|
  Rat   343 AGLTPTPPPSLKELLIK 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Snx21	NP_608709.1	PX_SNX20_21_like	71..188	CDD:132812	43/118 (36%)
Snx21	XP_008760780.1	PX_domain	121..232	CDD:295365	42/110 (38%)
		TPR repeat	234..258	CDD:276809	3/25 (12%)
		TPR_12	237..302	CDD:290160	16/69 (23%)
		TPR repeat	271..302	CDD:276809	8/33 (24%)
		TPR repeat	316..343	CDD:276809	6/26 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353883
Domainoid	1	1.000	64	1.000	Domainoid score	I9900
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H43132
Inparanoid	1	1.050	80	1.000	Inparanoid score	I5121
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1322681at2759
OrthoFinder	1	1.000	-	-		FOG0004256
OrthoInspector	1	1.000	-	-		otm44717
orthoMCL	1	0.900	-	-		OOG6_109685
Panther	1	1.100	-	-	LDO	PTHR20939
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6082
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.900