DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tnpo-SR and MTR10

DIOPT Version :9

Sequence 1:	NP_001259961.1	Gene:	Tnpo-SR / 33465	FlyBaseID:	FBgn0031456	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_014803.1	Gene:	MTR10 / 854331	SGDID:	S000005686	Length:	972	Species:	Saccharomyces cerevisiae

Alignment Length:	1007	Identity:	260/1007 - (25%)
Similarity:	445/1007 - (44%)	Gaps:	175/1007 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDTYSVDVVYQAISALFQGNNPKEQEKANKWLQDFQKSIYSWTIADELLHQKRD-----LHANYF 60
            ||...|..:..|:..:....:..::.||.::|:.||:|..:|:|.:|:| .|.|     |..|.|
Yeast     1 MDNLQVSDIETALQCISSTASQDDKNKALQFLEQFQRSTVAWSICNEIL-SKEDPTNALLELNIF 64

  Fly    61 AAQTMRNKIQNSFSELP---PHTHESLRDSLITHIGQIDEQTDNVIVTQLSLAVADLALLMASWR 122
            ||||:|||:....|:|.   |...:||...|::|       ...:|:|||::|:|.||:....|:
Yeast    65 AAQTLRNKVTYDLSQLENNLPQFKDSLLTLLLSH-------NQKLIITQLNVALARLAIQFLEWQ 122

  Fly   123 EPINDLLVTLAPHQCAIWPLLEVLKVLPEE---IDSRYL-RLGANRREEVHKQLDASAECVLKFL 183
            .||.: :::|.....:|  ||..|::||||   |.|..| .:..|.|  :|:.:|..||.|||||
Yeast   123 NPIFE-IISLLNSSPSI--LLNFLRILPEETLDIASTSLTEVEFNSR--IHELIDPIAEDVLKFL 182

  Fly   184 CMCLQREDLDQQRVWNAA--------LRTYSAWLVIHAFPVSHVYN-NALTQLAFRLLSL-PETS 238
            ..|:   ||.|....|::        ||..::|  .:.|||..:.. ..|..|.|..:|. .|:.
Yeast   183 VSCI---DLLQNTDGNSSSSISLEQILRCLNSW--SYEFPVEQLLTVQPLINLVFETISNGNESD 242

  Fly   239 GKLHDNATECVCALLSCINTRQDGASDPESSFEAQLFGAVCMLE--------TPYHLSVAHEDTD 295
            .:..|:|.:|:|.:|     |:...:..|....| ||..:.:|:        |.:.|:..::| |
Yeast   243 MEAFDSAIDCLCVIL-----RESRDTTNEQLISA-LFHQLMLLQEKLLPTLFTDHPLNDEYDD-D 300

  Fly   296 KTINYCRIFTSLCDAFFYDLLADAQKPHYSLKGLDLVLL---CVGHFDYEVAEITFHLWYKLSED 357
            ......|:|....:|:   .:..::.|.: .|.:.||||   |... |.:|...||..|:...:.
Yeast   301 LLEGMTRLFVEAGEAW---SVVISKNPDF-FKPMVLVLLMLTCKNE-DLDVVSYTFPFWFNFKQS 360

  Fly   358 L----FQRNEDKLTVLFRPHIERLISALFRHSQMESDHDGLIEENNNFFDFRRKVSDLIKDVAFI 418
            |    :|.:....:.:|    .:||:.:..|.|..|......||.:.|.|||..:.|::||...:
Yeast   361 LVLPRYQESRKAYSDIF----VKLINGIITHLQYPSGQFSSKEEEDKFKDFRYHMGDVLKDCTAV 421

  Fly   419 VGSGACFKQ-MFHILQAPE--TTWESTEAALFIMQNVAKNILPDENEVIPKVVEAILNMSEQTHI 480
            ||:.....| :..|..|.|  .:|:..||.||.::.:||.|...||.::|::::.|.|:.||..|
Yeast   422 VGTSEALSQPLIRIKSAIENNNSWQIMEAPLFSLRTMAKEISLTENTILPEIIKIICNLPEQAKI 486

  Fly   481 AVRYTAILLIGELCDWIENHPESLEAVLNFLLYALQQKNG------LAPAAAIALTSICSACRQK 539
              ||.:.|::|...:|...|||.||..|.::....|...|      :..|::.||...||.|.:.
Yeast   487 --RYASTLVLGRYTEWTAKHPELLEVQLQYIFNGFQLHEGSSDMQSIITASSHALMFFCSDCSKL 549

  Fly   540 MVCHISGLVEIARSLDSFQINNDVAIGLLKGISLILTRLPREQLQPALREIVGFQLQPLAQLV-- 602
            :|.:|..|:....::.| .|:.:....|.:|:|.::...|..::....:::|...|:.:..|:
Yeast   550 LVGYIDQLINFFLNVQS-SIDIESQFELCQGLSAVINNQPEAKVSVIFQKLVDDNLRQIEALIPQ 613

  Fly   603 ---DSTGSTPQKGERTDPVYWIDRACAIIRHTNP--DVPDNVEHPTVAILNDAWQLISRVM--DK 660
               :.|...||..::.|.:|      |:.....|  :.|.....|.:..:...|:.:..::  ..
Yeast   614 WKANPTLLAPQIADKIDLLY------ALFEELKPRYNYPQQGSEPLLPRIEFIWKALRTLLVDAG 672

  Fly   661 YQSDLRIMERTCRLIRYGIRMVRKQAMMLVEPLIKQMVVLYSVQHHSCFLYVGSILVDEFAKSSE 725
            ..:|..|:||..:|    :|.:.::..:..||::..:..         ||..| .|...|.....
Yeast   673 AMTDSIIVERVAKL----LRRIFERFHVFCEPILPSVAE---------FLIQG-YLTTGFGSYLW 723

  Fly   726 CIGGLLEML---QAF-IEPT-------FGLLQMEN-----------GLKNNPDTVDDFFRLASRY 768
            |.|.|:.:.   ::| |.|:       |.|.|.|.           .|.:..:.:.|||.|.|..
Yeast   724 CSGSLIVIFGDDESFPISPSLKDAVWKFALSQCETFILNFNKFDKLQLNDYHEAIIDFFSLISDL 788

  Fly   769 LDCCPHQLLQSS-LITPIFQCALIAC--SLDHREANSSVMKFFINLLVWGRSNNHSRNT------ 824
            :...|...|.|: |:.|:...|| .|  .||:.:|...:::...:::.||.........
Yeast   789 IMFYPGAFLNSTELLGPVLNVAL-ECVNKLDNYDAYICILRCLDDIISWGFKTPPISTVSIEIVP 852

  Fly   825 -ECRPLVV-ELASQHGGALVMNLI--QASVFQ--LHS---------------------YMLVD-V 861
             |.|..|: |:...||..|::.|.  ..:.|:  .||                     .:.:| :
Yeast   853 DEWRKQVINEVVIAHGNQLILVLFIGLVTTFENTAHSDAISCIVKCLRILTEANNNDATICIDWI 917

  Fly   862 AEVLHELKQVVGNERMQPFLAQA-LEALPKKN 892
            .:|:.:|.||..|||..  ||:| :|.|..|:
Yeast   918 YKVVEQLGQVTLNERDN--LAKAVVEGLNSKD 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnpo-SR	NP_001259961.1	IBN_N	28..94	CDD:281761	28/73 (38%)
		Xpo1	100..248	CDD:285575	52/161 (32%)
		HEAT repeat	427..454	CDD:293787	9/29 (31%)
		HEAT repeat	462..496	CDD:293787	10/33 (30%)
		HEAT repeat	506..531	CDD:293787	6/30 (20%)
MTR10	NP_014803.1	IBN_N	28..97	CDD:197981	27/69 (39%)
MTR10	NP_014803.1	Xpo1	100..253	CDD:400614	52/162 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341960
Domainoid	1	1.000	134	1.000	Domainoid score	I1101
eggNOG	1	0.900	-	-		E1_KOG2081
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40848
Inparanoid	1	1.050	219	1.000	Inparanoid score	I776
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55013
OrthoFinder	1	1.000	-	-		FOG0004702
OrthoInspector	1	1.000	-	-		oto99129
orthoMCL	1	0.900	-	-		OOG6_103041
Panther	1	1.100	-	-	O	PTHR12363
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1966
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790