Protein Alignment Tnpo-SR and KAP122

DIOPT Version :10

• Sequence 1: NP_608708.2
• Gene: Tnpo-SR / 33465
• FlyBaseID: FBgn0031456
• Length: 932
• Species: Drosophila melanogaster
• Sequence 2: NP_011499.1
• Gene: KAP122 / 852868
• SGDID: S000002984
• Length: 1081
• Species: Saccharomyces cerevisiae
• Alignment Length: 1102
• Identity: 220/1102 - (19%)
• Similarity: 387/1102 - (35%)
• Gaps: 341/1102 - (30%)

  Fly     5 SVDVVYQAISALFQGNNPKEQEKANKWLQDFQKSIYSWTIADELL-HQKRDLHANYFAAQTMRNK 68
            |:..|...|..|:..:...:..:..:.||..|||...:.:|:||| ..|...:..||.|.|:..:
Yeast     3 SIHEVVALIEELYSPHPKHDVNQIQQSLQSIQKSEQGFHLANELLSDDKYSANVKYFGALTLTVQ 67

  Fly    69 IQNSFSELPPHTHESL----RDSL--ITHIGQIDEQTDNV----------IVTQLSL---AVADL 114
            : |:..|   :.:|:|    |.:|  :|....:.....|:          :::.|||   .:.|.
Yeast    68 L-NTRGE---NDYETLWNVFRSNLLYLTKFSTLYVSNPNMYGQSLIIIKKLMSNLSLIFTKINDP 128

  Fly   115 AL-------LMASWREPINDLLVTLAPHQCAIWPLLEVLKVLPEEIDSRYLRLGANRREEVHKQL 172
            .|       ::..|..|||              ..::::.|..:.|::..|.|.:......::||
Yeast   129 QLNNAGNENMIKQWNNPIN--------------TFIQLMSVQNQNINADQLLLDSINCSLTYEQL 179

  Fly   173 DASA-------ECVLKFLCMCLQREDLDQQRVWNAALRTYSAWLVIHAFPVSHVYNNALTQLAFR 230
            ....       |..|.|..:.:  |||.:.:....::..      ||.....|:|.:.:..:...
Yeast   180 SQFVSLSQKHNELALTFTEVIV--EDLTKFQTKRHSMSQ------IHEVVHEHLYISTMALINLN 236

  Fly   231 LLSLPETSGKLHDNATECVCALLSCIN-TR---QDGASDPESSFE-------------------- 271
            |.:    ....:....:|:.|.::.|: ||   ..|..|....|:
Yeast   237 LTA----QAVFNPTVFDCITAWINYISLTRSVSSSGRMDLSEIFQNLIDLMYQSTEGSDGYENAE 297

  Fly   272 --AQLFGAV-----------------CMLETPYHLSVAHEDTDKT-------------------- 297
              ..:||.|                 |:.     |.|...|:..|
Yeast   298 KILTIFGNVFANDPLLMSYDLRQQIECIF-----LGVVRPDSGITDISNKNSWMLQYMNYLVTND 357

  Fly   298 ------------INYCRIFT-SLCDAFFYDLLA--DAQKPHYSLKGLDLVLLCVGHFD------- 340
                        :::.:|.| |:|:..|.::.|  :.|.....::....|||.:.:|.
Yeast   358 FFSELKELAICIVDFLQINTLSVCNKLFTNIQAADNGQVQDEYIQEYIKVLLQMTNFPLTPVLQE 422

  Fly   341 -YEVAEITFHLWYKLSEDLFQRNEDKLTVLFRPHIERLISALFRH-------------SQMESDH 391
             :.|..:.|  |..||:.......:.|    ||:...|.:.:|:.             .|...:.
Yeast   423 FFSVRMVDF--WLDLSDAYTNLASETL----RPNSIELSTQIFQQLINIYLPKISLSVKQRIIEE 481

  Fly   392 DGLIEENNNFFDFRRKVSDLIKDVAFIVGSGACFKQMFHIL-----QAPETTWES---------- 441
            :|.....|.|.|||..||||.:.:..|:|:    ..:.::|     |.|..:.|:
Yeast   482 EGESTSVNEFEDFRNAVSDLAQSLWSILGN----DNLTNVLIDGMGQMPAASDETLIIKDTDVLF 542

  Fly   442 -TEAALFIMQNV-----------AKNILPDENEVIPKVVEAILNMSEQTHIAVRYTAIL------ 488
             .|...|::..:           .|||: |.|:...:.|.::.....||..:.:.:.||
Yeast   543 RIETMCFVLNTILVDMTLSESPWIKNIV-DANKFFNQNVISVFQTGFQTSASTKVSQILKLDFVR 606

  Fly   489 ----LIGELCDWIENHP-----------ESLEAVLNFLLYALQQK---NGLAPAAAIALTSICSA 535
                |||.|..:.:..|           :.|....||.....|:|   :.|.......::::|..
Yeast   607 TSTTLIGTLAGYFKQEPFQLNPYVEALFQGLHTCTNFTSKNEQEKISNDKLEVMVIKTVSTLCET 671

  Fly   536 CRQKMVCHISGLVEIARSL---DSFQINNDVAIGLLKGISLI----LTRLPREQLQPALREIVGF 593
            ||:::..::...:....::   || .:::.....|::.|..:    ::..|.||.:..|:
Yeast   672 CREELTPYLMHFISFLNTVIMPDS-NVSHFTRTKLVRSIGYVVQCQVSNGPEEQAKYILQ----- 730

  Fly   594 QLQPLAQLVDST-----GSTPQKGERTDPV----YWI-DRACAIIRHTNPDVPDNVEHPTVAILN 648
                |..|:..:     .|:.|..|:.|.:    |.| :.|.::|:            ||..|.|
Yeast   731 ----LTNLLSGSIEHCLASSVQLQEQQDYINCLLYCISELATSLIQ------------PTEIIEN 779

  Fly   649 DA-----------W-----QLISRVM---DK------YQSDLRIMERTCRLIRYGIRMVRKQAMM 688
            ||           |     |:.|::|   ||      |..:...:|..|.::..|:.:...:...
Yeast   780 DALLQRLSEFQSFWSSDPLQIRSKIMCTIDKVLDNSIYCKNSAFVEIGCLIVGKGLNLPDGEPYF 844

  Fly   689 LVEPLIKQM-VVLYSVQH---HSC---FLYVGSILVDEFAKS---------SECIGGLLEMLQAF 737
            |...:.:.| .||..|.:   .:|   |:|:...|:.||.|.         .|.|  ||....|:
Yeast   845 LKYNMSEVMNFVLRHVPNCELATCLPYFVYLLEKLISEFRKELTPQEFDFMFEKI--LLVYYDAY 907

  Fly   738 IEPTFGLLQMENGLKNNPDTVDDFFRLASRYLDCCPHQLLQSSLITPIFQCALIACSLDHREANS 802
            |.....||||..|..||...|.....:.|::         .:|.|.|.| ..||    ..||..:
Yeast   908 IINDPDLLQMTIGFVNNVLDVKPGLAIGSKH---------WTSFILPQF-LKLI----PSREKFT 958

  Fly   803 --SVMKFFINLLVWGRSNNHSRNTECRPLVVELASQHGGALVMNLI------QASVFQLHSY 856
              :|.||:..|:     ||...|.|....|.:..|..||.||..::      |.|  .|:||
Yeast   959 IVAVAKFWTKLI-----NNKKYNQEELTTVRQQVSSIGGDLVYQIMYGLFHTQRS--DLNSY 1013

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tnpo-SR	NP_608708.2	IBN_N	28..94	CDD:197981	21/72 (29%)
		Xpo1	100..249	CDD:462459	27/175 (15%)
		HEAT repeat	427..454	CDD:293787	6/53 (11%)
		HEAT repeat	462..496	CDD:293787	9/43 (21%)
		HEAT repeat	506..531	CDD:293787	5/27 (19%)
KAP122	NP_011499.1	None