DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tnpo-SR and MOS14

DIOPT Version :9

Sequence 1:	NP_001259961.1	Gene:	Tnpo-SR / 33465	FlyBaseID:	FBgn0031456	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_201066.2	Gene:	MOS14 / 836381	AraportID:	AT5G62600	Length:	958	Species:	Arabidopsis thaliana

Alignment Length:	973	Identity:	245/973 - (25%)
Similarity:	431/973 - (44%)	Gaps:	90/973 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 DVVYQAISALFQGNNPKEQEKANKWLQDFQKSIYSWTIADELLH-QKRDLHANYFAAQTMRNKIQ 70
            :.|.:|::||:...:...:..|::|||:||.::.:|.:||.||| ...:|....|.:||:|:|:|
plant     5 NAVKEALNALYHHPDDTVRVHADRWLQNFQGTLDAWQVADNLLHDSSSNLETLIFCSQTLRSKVQ 69

  Fly    71 NSFSELPPHTHESLRDSLITHIGQIDEQTDNVIVTQLSLAVADLALLM--ASWREP--INDLLVT 131
            ..|.||||...:.||.||.|.:.:..:....| .||:|:|||.||:.:  |.|.:.  |:.|...
plant    70 RDFEELPPGAFQKLRQSLTTLLKKFHKGPPKV-RTQISIAVAALAVHVPAADWGDGGIISWLRDE 133

  Fly   132 LAPHQCAIWPLLEVLKVLPEEIDSRYLRLGANRREEVHKQLDASAECVLKFLCMCLQREDLDQQR 196
            :..|...:...||:|.|||||..:..:....:||.:..|:|.:..|..|..|..||:..:|.:|
plant   134 MHMHPEYVPGFLELLTVLPEETFNYKIAARPDRRRQFEKELTSQMEAALSILSACLKISELKEQ- 197

  Fly   197 VWNAALRTYSAWLVI-HAFPVSHVYNNALTQLAFRLLSLPETSGKLHDNATECVCALLSCINTRQ 260
                .|..:::||.: |..|.:.:..:.|...|...|:.        |..:|....::|.:....
plant   198 ----VLEAFASWLRLRHGIPGTVLACHPLVHAALSSLNC--------DPLSEASVNVISELIHHT 250

  Fly   261 DGASDPESSFEAQLFGAVC--MLETPYHLSVAHEDTDKTINYCRIFTSLCDAFFYDLLADAQKPH 323
            ...|....|.:..|...:.  :|....||..:.:|.:......|:|..:.|::...:...:.:|.
plant   251 ASPSSGGISAQTPLIQVIVPQILSLQAHLRDSSKDEEDVKAIGRLFADVGDSYVELIATGSDEPM 315

  Fly   324 YSLKGLDLVLLCVGHFDYEVAEITFHLWYKLSEDLFQR-------NEDKLTV-------LFRPHI 374
            ..:..|   |....|.::::|.:||:.|:.|...|.:|       :|..:.|       :|:|..
plant   316 VIVHAL---LEVTAHPEFDIASMTFNFWHSLQLMLTKRESYSSLGSEASIEVERNRRLHIFQPAY 377

  Fly   375 ERLISALFRHSQMESDHDGL-IEENNNFFDFRRKVSDLIKDVAFIVGSGACFKQMF-HILQAPET 437
            :.|:|.:....|...|:.|| .|:...|...|..|:|::.|.|.|:|.....|.:: .:|:|...
plant   378 QSLVSLVGFRVQYPEDYQGLSYEDLKEFKQTRYAVADVLIDAALILGGDTTLKILYMKLLEANAQ 442

  Fly   438 T------WESTEAALFIMQNVAKNILPDENEVIPKVVEAILNMSEQTHIAVRYTAILLIGELCDW 496
            |      |...||.||.:..::..:...|.||:|:|:..:.|:.:|..:.  .||.||:|....|
plant   443 TGNNFQDWRPAEAILFCIWAISNYVSVVEAEVMPQVMALLQNLPQQAQLL--QTACLLVGAYSKW 505

  Fly   497 IENHPES---LEAVLNFLLYALQQKNGLAPAAAIALTSICSACRQKMVCHISGLVEI----ARSL 554
            :...|.|   |.:::..|:..:......|.|||:|....|..||:.:..:...|..|    ....
plant   506 LNAAPASVSILPSIIRILMSGMGTSEDCAAAAALAFRHTCDDCRKNLCGYFEDLFNIYCMAINGG 570

  Fly   555 DSFQINNDVAIGLLKGISLILTRLPREQLQPALREIVGFQLQPLAQLVDSTGSTPQKGERTDPVY 619
            ..::::.:.::.|::.:.:::|.||.:|.:.||.::......||.:....  ...:|..|...|:
plant   571 GGYKVSAEDSLNLVEALGMVVTELPLDQAKGALEKLCFSAASPLEEAAKE--DLEKKHARELTVH 633

  Fly   620 WIDRACAIIRHTNPDVPDNVEHP--TVAILNDAWQLISRVMDKYQSDLRIMERTCRLIRYGIRMV 682
             |||...:.|:.|        ||  ..|.:|..|.:...:.|....|:|.||..||..:|.:|..
plant   634 -IDRFAFLFRYVN--------HPEAVAAEINKHWAIFRVIFDARPWDMRTMESLCRACKYAVRTS 689

  Fly   683 RKQAMMLVEPLIKQMVVLYSVQHHSCFLYVGSILVDEFAKSSECIGGLLEMLQAFIEPTFGLLQM 747
            .:..:..:..:::::...|...|..||||:.|.::..|.....|...|..:::.....|..|:..
plant   690 GRYIIDTIGEMLEKIQFHYQQHHQPCFLYLSSEVIKIFGSDPSCAVYLKNLIETLFAHTTCLMTS 754

  Fly   748 ENGLKNNPDTVDDFFRLASRYLDCCPHQLLQSSLITPIFQCALIACSLDHREANSSVMKFFINLL 812
            ...:...||..||.|.||||.|..|||..:.|.:...:..||:|..::.||||..|::.|..::.
plant   755 IKEVTARPDIADDCFLLASRCLRYCPHLFIPSPIFPALVNCAMIGITVQHREACHSILTFLTDIF 819

  Fly   813 VWGRSNNHSR-------------NTECRPLVVELASQHGGALVMNLIQASVFQL----HSYMLVD 860
            ...:|.|..:             .|..|.|:..||    |||..:.:....:.|    .:|.|..
plant   820 DLEKSVNEEQFVRIRDNIIIPRGATITRILIASLA----GALPSSRLDTVTYSLLALTRTYRLQA 880

  Fly   861 VAEVLHELKQVVGNERMQPFLAQALEALPKKNSGGYVTATQQQLDEFSSTVLRADTTKAISQA 923
            |:.....:..:......:....:.|:||.....|..|.:...|::|.|....|..|.:.:.||
plant   881 VSWAKESVSLIPRTALTETESTKFLQALSDIAYGADVNSLIGQVEELSDVCRRNRTVQELVQA 943

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnpo-SR	NP_001259961.1	IBN_N	28..94	CDD:281761	29/66 (44%)
		Xpo1	100..248	CDD:285575	42/152 (28%)
		HEAT repeat	427..454	CDD:293787	8/33 (24%)
		HEAT repeat	462..496	CDD:293787	11/33 (33%)
		HEAT repeat	506..531	CDD:293787	6/24 (25%)
MOS14	NP_201066.2	IBN_N	26..91	CDD:197981	29/64 (45%)
MOS14	NP_201066.2	Xpo1	98..243	CDD:285575	43/158 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	194	1.000	Domainoid score	I920
eggNOG	1	0.900	-	-		E1_KOG2081
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40848
Inparanoid	1	1.050	284	1.000	Inparanoid score	I861
OMA	1	1.010	-	-		QHG55013
OrthoDB	1	1.010	-	-		D206228at2759
OrthoFinder	1	1.000	-	-		FOG0004702
OrthoInspector	1	1.000	-	-		oto4098
orthoMCL	1	0.900	-	-		OOG6_103041
Panther	1	1.100	-	-	O	PTHR12363
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840