DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tnpo-SR and cdm

DIOPT Version :9

Sequence 1:	NP_001259961.1	Gene:	Tnpo-SR / 33465	FlyBaseID:	FBgn0031456	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_001262696.1	Gene:	cdm / 42171	FlyBaseID:	FBgn0261532	Length:	971	Species:	Drosophila melanogaster

Alignment Length:	912	Identity:	177/912 - (19%)
Similarity:	382/912 - (41%)	Gaps:	131/912 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDTYSVDVVYQAISALFQGNNPKEQEKANKWLQDFQKSIYSWTIADELLHQKRDLHANYFAAQTM 65
            |:...:..:.:|:.:.::.|: :.|...::||.|.:.|..:|..:.:|:...:.....:|.|.|:
  Fly     1 MEPIDIARLEEAVVSFYRSNS-QNQAITHEWLTDAEASPQAWQFSWQLMQLGKSQEVQFFGAITL 64

  Fly    66 RNKIQNSFSELPPHTHESLRDSLITHIGQIDEQTDNVIVTQLSLAV-ADLALLMASWREPINDLL 129
            .:|:...:.|:||...|.|:..::..|.:. .....:::.:|.::: |.:..::..|...|.:::
  Fly    65 HSKLMKHWHEVPPENREELKQKILESIVRF-AGGPKIVLNRLCISLGAYIVHMLGEWPGAIEEVI 128

  Fly   130 VTL----APHQCA---IWPLLEVLKVLPEEIDSRYLRLGANR---REEVHKQLDASAECVLKFLC 184
            .|.    .|:..|   :|.:||||..:|||  ::.:.....|   |.|:.|::......|.::|
  Fly   129 NTFQNQRMPNVSADVQLWIMLEVLTAIPEE--AQVIHTSVKRVVLRAEIAKRVQLVIHTVERYL- 190

  Fly   185 MCLQREDLDQQRVW--------NAALRTYSAWL-------------------VIHA--FPVSHVY 220
                  .|...|||        |.|::....|:                   |:|.  :|..|..
  Fly   191 ------KLQMNRVWDAEAYSNMNRAVKCVGTWIKNIGYTIEGCVTITAVLLEVVHKCYWPCIHAG 249

  Fly   221 NNALTQLAFRLLSLPETSGKLHDNATECVCALLSCINTRQDGASDPESSFE-AQLFGAVCMLETP 284
            :..:|             ...::.|..|:..:::.| .:.|..:.|:::|. .::|.......|.
  Fly   250 DGCMT-------------ADENELAESCLKTMVNII-IQPDCHNYPKTAFVLIKMFLDSLSEITK 300

  Fly   285 YHLSVAHEDTDKTINYCRIFTSLCDAFFYDLLA--DAQKPHYSL---KGLDLVLLCV---GHFDY 341
            ......:::.|..::...:|.|..:.....||:  .:..|..|:   :.:..:|.|.   |.:..
  Fly   301 TEWKRENDNEDIIVHIYMLFVSSVERHSTLLLSGITSADPELSILVHRIVQEILHCTDKPGIYPV 365

  Fly   342 EVAEITFHL--WYKLSEDLFQRNED----KLTVLFRPHIERLISALFRHSQMESDHDGLIEENNN 400
            |.:..|..|  ||.|.:::|..:.|    |.....:|....|...|.|.|: :.|...|.:.:::
  Fly   366 EESCSTMALAFWYMLQDEVFAMSNDEQKHKCWEYIKPLYAHLTRILVRKSE-QPDEKSLAKWSSD 429

  Fly   401 ----FFDFRRKVS-------DLIKDVAFIVGSGACFKQMFHILQAPETTWESTEAALFIMQNVAK 454
                |..:|:.:|       |::.|....: ..|...:....||...|.|...||.::..|:||:
  Fly   430 DLECFRCYRQDISDTFMYCYDVLNDYILEI-LAAMLDEAIADLQRHPTHWTKLEACIYSFQSVAE 493

  Fly   455 NILPDENEVIPKVVEAILNMS-EQTHIAVRYTAILLIGELCDWIENHPESLEAVLNFLLYALQQK 518
            :...:|...||:::..:..:. |:.::.:..||:..:|..|:|:..:|..:...:|.|:..|  .
  Fly   494 HFGGEEKRQIPRLMRVLAEIPYEKLNVKLLGTALETMGSYCNWLMENPAYIPPAINLLVRGL--N 556

  Fly   519 NGLAPAAAIALTSICSACRQKM---------VCHISGLVEIARSLDSFQINNDVAIGLLKGISLI 574
            :.::..|.:.|..:|..|:.::         .||        .||::.::.|..::.|:..|..:
  Fly   557 SSMSAQATLGLKELCRDCQLQLKPYADPLLNACH--------ASLNTGRMKNSDSVRLMFSIGKL 613

  Fly   575 LTRLPREQLQPALREIVGFQLQPLAQLVDSTGSTPQKGERTDPVYWIDRACAIIRHTNPDVPDN- 638
            ::.|..|::...|..||....:.|..:..:...||....||  ::.::....:....|.||.:.
  Fly   614 MSLLRPEEIPKYLDIIVSPCFEELQAICQADSKTPAARIRT--IFRLNMISTLFSSLNTDVDEQA 676

  Fly   639 ----VEHPTVAILNDAWQLISRVMDKYQSDLRIMERTCRLIRYGIRMVRKQAMMLVEPLIKQMVV 699
                :..|.:.::.....:..|:.:.:..::.::|..|..:::.|..:|.....:::.|.  :.:
  Fly   677 TDQPIVQPVLLVMQRTMPIFKRIAEMWVEEIDVLEAACSAMKHAITNLRSSFQPMLQDLC--LFI 739

  Fly   700 LYSVQHHSC--FLYVGSILVDEFAKSSECIGGLLEMLQAFIEPTFGLLQM--ENGLKNNPDTVDD 760
            :.|.|...|  .|.:....:..|.|...|...:.::|:.||:.:|.|.:.  |....|..||::.
  Fly   740 VASFQTRCCAPTLEISKTAIVMFFKDEGCKPLMQQLLREFIQHSFKLFESTPEQNFSNISDTMET 804

  Fly   761 FFRLASRYLDCCPHQLLQSSLITP--IFQCALIACSLDHREANSSVMKFFINLLVWGRSNNHSRN 823
            ||...::.:...|..|...:|...  :|. |....:|....|..:.::|..:.::  :|.||:..
  Fly   805 FFGCLTQIIKKIPQVLEDKTLAYDRLVFY-AQRGMTLPESGAIRNSIQFLTHFVM--QSRNHAHV 866

  Fly   824 TE 825
            ||
  Fly   867 TE 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnpo-SR	NP_001259961.1	IBN_N	28..94	CDD:281761	16/65 (25%)
		Xpo1	100..248	CDD:285575	34/187 (18%)
		HEAT repeat	427..454	CDD:293787	8/26 (31%)
		HEAT repeat	462..496	CDD:293787	7/34 (21%)
		HEAT repeat	506..531	CDD:293787	5/24 (21%)
cdm	NP_001262696.1	IBN_N	28..92	CDD:281761	15/63 (24%)
cdm	NP_001262696.1	Xpo1	98..>217	CDD:285575	27/127 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45441203
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12363
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940