DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tnpo-SR and tnpo3

DIOPT Version :9

Sequence 1:	NP_001259961.1	Gene:	Tnpo-SR / 33465	FlyBaseID:	FBgn0031456	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_957381.1	Gene:	tnpo3 / 394062	ZFINID:	ZDB-GENE-040426-708	Length:	923	Species:	Danio rerio

Alignment Length:	934	Identity:	408/934 - (43%)
Similarity:	595/934 - (63%)	Gaps:	23/934 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SVDVVYQAISALFQGNNPKEQEKANKWLQDFQKSIYSWTIADELLHQKRDLHANYFAAQTMRNKI 69
            ::.:||||:.||:...:|..:|:|:.||.:.|:|:|:|.|:|:||..|:|:.:.|||||||:.||
Zfish     7 TLPLVYQAVQALYHDPDPAGKERASVWLGELQRSMYAWEISDQLLQLKQDIESCYFAAQTMKMKI 71

  Fly    70 QNSFSELPPHTHESLRDSLITHIGQIDEQTDNVIVTQLSLAVADLALLMASWREPINDLLVTLAP 134
            |.||.||||.:|.:|||||::||..:.:.:. :|||||:||:|||||.||||:..::.|:...:.
Zfish    72 QTSFYELPPDSHTALRDSLLSHIQNLKDLSP-IIVTQLALAIADLALQMASWKGCVHTLIEKYSN 135

  Fly   135 HQCAIWPLLEVLKVLPEEIDSRYLRLGANRREEVHKQLDASAECVLKFLCMCLQREDLDQQRVWN 199
            ...::..|:|:|.|||||:.||.||:|||||.|:.:.|...:..|:..|..|.::...|::.:..
Zfish   136 DVSSMTFLIEILTVLPEEVHSRSLRIGANRRTEIIEDLAYYSTTVVTLLVTCAEKSGHDEKMLIK 200

  Fly   200 AALRTYSAWLVIHAFPVSHVYNNALTQLAFRLLSLPETSGKLHDNATECVCALLSCINTRQDGAS 264
             ..|...:|..:.....:.:.||.|..:.|::|...|||..||:.|::|||:.|..|
Zfish   201 -VFRCLGSWFNLGVLDNNFMANNQLLMILFQVLQRDETSTNLHEAASDCVCSALYAI-------- 256

  Fly   265 DPES-----SFEAQLFGAVCMLETPYHLSVAHEDTDKTINYCRIFTSLCDAFFYDLLADAQKPHY 324
              |:     ....|||..|..|||.||::||.||.||.:|||||||.||:.|....:....:...
Zfish   257 --ENVAIHLPLAMQLFQGVLTLETAYHMAVAREDLDKVLNYCRIFTELCETFLEMTVRTPGQGMG 319

  Fly   325 SLKGLDLVLLCVGHFDYEVAEITFHLWYKLSEDLFQRNEDKLTVLFRPHIERLISALFRHSQMES 389
            .|:.|:|:|:|.||..|||.||:|:.||:|.|.|::.|:..|..:|||:|:||:.:|.||.|::.
Zfish   320 DLRTLELLLICAGHPQYEVVEISFNFWYRLGEHLYKINDPALHNVFRPYIQRLLHSLARHCQLDP 384

  Fly   390 DHDGLIEENNNFFDFRRKVSDLIKDVAFIVGSGACFKQMFHILQAPETTWESTEAALFIMQNVAK 454
            ||:|:.|:.::|.:||.:||||:|||.|:|||..||.|::..|:.....||.|||.||||.::||
Zfish   385 DHEGVPEDTDDFGEFRMRVSDLVKDVIFLVGSMECFAQLYSTLREGNPPWEVTEAVLFIMASIAK 449

  Fly   455 NILPDENEVIPKVVEAILNMSEQTHIAVRYTAILLIGELCDWIENHPESLEAVLNFLLYALQQKN 519
            |:.|:.|..:.:|:|.|:.:.|..|:|||||:|.|:||:.:.|:.:|..|:.|||||:..|::|
Zfish   450 NVDPENNPTLMEVLEQIVLLPETVHLAVRYTSIELVGEMSEVIDRNPSMLDTVLNFLMKGLREK- 513

  Fly   520 GLAPAAAIALTSICSACRQKMVCHISGLVEIARSLDSFQINNDVAIGLLKGISLILTRLPREQLQ 584
            .||.|||.|:.:|||.||..|..|..||::||||||||.::.|.|:|||||.:|:|.|||.|::.
Zfish   514 PLASAAAKAIHNICSVCRDHMAQHFQGLLDIARSLDSFALSTDAAVGLLKGTALVLARLPLEKIA 578

  Fly   585 PALREIVGFQLQPLAQLVDSTGSTPQKGERTDPVYWIDRACAIIRHTNPDVPDNVEHPTVAILND 649
            ..|.::...|:..|.:|:....|:   |:.:||..|:||...|.|||||.|.:...||...::.:
Zfish   579 ECLNDLCAVQVMALKKLLAQDSSS---GKSSDPTVWLDRLAVIFRHTNPIVENGQTHPCQKVIQE 640

  Fly   650 AWQLISRVMDKYQSDLRIMERTCRLIRYGIRMVRKQAMMLVEPLIKQMVVLYSVQHHSCFLYVGS 714
            .|.::|..::.:|||.||:||.||.:|:.:|.|.|.:..|::||:.|||.:|.:..||||||:||
Zfish   641 IWPVLSETLNAHQSDNRIVERCCRCLRFAVRCVGKGSASLLQPLVTQMVSVYQLYPHSCFLYLGS 705

  Fly   715 ILVDEFAKSSECIGGLLEMLQAFIEPTFGLLQMENGLKNNPDTVDDFFRLASRYLDCCPHQLLQS 779
            |||||:.....|..|||:||||...|||.||:..|||:|:||||||.||||:|::...|..||.|
Zfish   706 ILVDEYGMEEGCRQGLLDMLQALCMPTFQLLEQPNGLRNHPDTVDDLFRLATRFVQRSPVTLLSS 770

  Fly   780 SLITPIFQCALIACSLDHREANSSVMKFFINLLVWGRSNNHSRNTECRP-LVVELASQHGGALVM 843
            |:|..|.|||:.|.:||||:||.|||||..:|:..|.:|:|..:.|.|. |:.:...|||..||.
Zfish   771 SIIVHIIQCAIAATTLDHRDANCSVMKFIRDLIHTGVTNDHEDDFEVRKRLIGQAMEQHGQQLVN 835

  Fly   844 NLIQASVFQLHSYMLVDVAEVLHELKQVVGNERMQPFLAQALEALPKKNSGGYVTATQQQLDEFS 908
            .||....|.|..|.|.||||||.|: .|........:|...|:.|||:.:||.||.|.:||.:|.
Zfish   836 QLINTCCFCLPPYTLPDVAEVLWEI-MVFDRPTFCRWLETTLKGLPKETAGGAVTVTHKQLTDFH 899

  Fly   909 STVLRADTTKAISQALKTFTRLFR 932
            ..|..|:..|.:..|::.||||:|
Zfish   900 KQVTSAEECKQVCWAIREFTRLYR 923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnpo-SR	NP_001259961.1	IBN_N	28..94	CDD:281761	37/65 (57%)
		Xpo1	100..248	CDD:285575	53/147 (36%)
		HEAT repeat	427..454	CDD:293787	11/26 (42%)
		HEAT repeat	462..496	CDD:293787	14/33 (42%)
		HEAT repeat	506..531	CDD:293787	13/24 (54%)
tnpo3	NP_957381.1	IBN_N	30..96	CDD:197981	37/65 (57%)
tnpo3	NP_957381.1	Xpo1	120..248	CDD:285575	40/128 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575787
Domainoid	1	1.000	586	1.000	Domainoid score	I201
eggNOG	1	0.900	-	-		E1_KOG2081
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40848
Inparanoid	1	1.050	770	1.000	Inparanoid score	I523
OMA	1	1.010	-	-		QHG55013
OrthoDB	1	1.010	-	-		D179626at33208
OrthoFinder	1	1.000	-	-		FOG0004702
OrthoInspector	1	1.000	-	-		oto41369
orthoMCL	1	0.900	-	-		OOG6_103041
Panther	1	1.100	-	-	LDO	PTHR12363
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1966
SonicParanoid	1	1.000	-	-		X5042
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800