DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tnpo-SR and Tnpo3

DIOPT Version :9

Sequence 1:	NP_001259961.1	Gene:	Tnpo-SR / 33465	FlyBaseID:	FBgn0031456	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_001334008.1	Gene:	Tnpo3 / 320938	MGIID:	1196412	Length:	929	Species:	Mus musculus

Alignment Length:	941	Identity:	399/941 - (42%)
Similarity:	593/941 - (63%)	Gaps:	31/941 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SVDVVYQAISALFQGNNPKEQEKANKWLQDFQKSIYSWTIADELLHQKRDLHANYFAAQTMRNKI 69
            ::.:||||:.||:...:|..:|:|:.||.:.|:|:::|.|:|:||..::|:.:.|||||||:.||
Mouse     7 TLQLVYQAVQALYHDPDPSGKERASFWLGELQRSVHAWEISDQLLQIRQDVESCYFAAQTMKMKI 71

  Fly    70 QNSFSELPPHTHESLRDSLITHIGQIDEQTDNVIVTQLSLAVADLALLMASWREPINDLL----- 129
            |.||.|||..:|.||||||:|||..:.:.:. ||||||:||:|||||.|.||:..:..|:
Mouse    72 QTSFYELPTDSHASLRDSLLTHIQNLKDLSP-VIVTQLALAIADLALQMPSWKGCVQTLVEKYSN 135

  Fly   130 -VTLAPHQCAIWPLLEVLKVLPEEIDSRYLRLGANRREEVHKQLDASAECVLKFLCMCLQREDLD 193
             ||..|.      |||:|.|||||:.||.||:|||||.|:.:.|...:..|:..|..|:::...|
Mouse   136 DVTSLPF------LLEILTVLPEEVHSRSLRIGANRRTEIIEDLAFYSSTVVSLLMTCVEKAGTD 194

  Fly   194 QQRVWNAALRTYSAWLVIHAFPVSHVYNNALTQLAFRLLSLPETSGKLHDNATECVCALLSCINT 258
            ::.:.. ..|...:|..:.....:.:.||.|..|.|.:|...:||..||:.|::|||:.|..|..
Mouse   195 EKMLMK-VFRCLGSWFNLGVLDSNFMANNKLLALLFEVLQQDKTSSNLHEAASDCVCSALYAIEN 258

  Fly   259 RQDGASDPESSFEAQLFGAVCMLETPYHLSVAHEDTDKTINYCRIFTSLCDAFFYDLLADAQKPH 323
                 .:.......|||..|..|||.||::||.||.||.:|||||||.||:.|...::....:..
Mouse   259 -----VETNLPLAMQLFQGVLTLETAYHMAVAREDLDKVLNYCRIFTELCETFLEKIVCTPGQGL 318

  Fly   324 YSLKGLDLVLLCVGHFDYEVAEITFHLWYKLSEDLFQRNEDKLTVLFRPHIERLISALFRHSQME 388
            ..|:.|:|:|:|.||..|||.||:|:.||:|.|.|::.|::.:..:|:.:|:||:.||.||.|:|
Mouse   319 GDLRTLELLLICAGHPQYEVVEISFNFWYRLGEHLYKTNDEVIHSIFKAYIQRLLHALARHCQLE 383

  Fly   389 SDHDGLIEENNNFFDFRRKVSDLIKDVAFIVGSGACFKQMFHILQAPETTWESTEAALFIMQNVA 453
            .||:|:.||.::|.:||.:||||:||:.|::||..||.|::..|:.....||.|||.||||..:|
Mouse   384 PDHEGVPEETDDFGEFRMRVSDLVKDLIFLIGSMECFAQLYSTLKEGNPPWEVTEAVLFIMAAIA 448

  Fly   454 KNILPDENEVIPKVVEAILNMSEQTHIAVRYTAILLIGELCDWIENHPESLEAVLNFLLYALQQK 518
            |::.|:.|..:.:|:|.::::.|..|.|||||:|.|:||:.:.::.:|:.|:.||.:|:..|.:|
Mouse   449 KSVDPENNPTLVEVLEGVVHLPETVHTAVRYTSIELVGEMSEVVDRNPQFLDPVLGYLMKGLCEK 513

  Fly   519 NGLAPAAAIALTSICSACRQKMVCHISGLVEIARSLDSFQINNDVAIGLLKGISLILTRLPREQL 583
             .||.|||.|:.:|||.||..|..|.:||:|||.|||||.::.:.|:|||||.:|:|.|||.:::
Mouse   514 -PLASAAAKAIHNICSVCRDHMAQHFNGLLEIAHSLDSFMLSPEAAVGLLKGTALVLARLPLDKI 577

  Fly   584 QPALREIVGFQLQPLAQLVDSTGSTPQKGERTDPVYWIDRACAIIRHTNPDVPDNVEHPTVAILN 648
            ...|.|:...|:..|.:|:   ...|..|..:||..::||...|.|||||.|.:...||...::.
Mouse   578 TECLSELCSVQVMALKKLL---SQEPSNGISSDPTVFLDRLAVIFRHTNPIVENGQTHPCQKVIQ 639

  Fly   649 DAWQLISRVMDKYQSDLRIMERTCRLIRYGIRMVRKQAMMLVEPLIKQMVVLYSVQHHSCFLYVG 713
            :.|.::|..::|:::|.||:||.||.:|:.:|.|.|.:..|::||:.|||.:|.|..||||||:|
Mouse   640 EIWPVLSETLNKHRADNRIVERCCRCLRFAVRCVGKGSAALLQPLVTQMVNVYHVHQHSCFLYLG 704

  Fly   714 SILVDEFAKSSECIGGLLEMLQAFIEPTFGLLQMENGLKNNPDTVDDFFRLASRYLDCCPHQLLQ 778
            ||||||:.....|..|||:||||...|||.||:.:|||:|:||||||.||||:|::...|..||:
Mouse   705 SILVDEYGMEEGCRQGLLDMLQALCIPTFQLLEQQNGLQNHPDTVDDLFRLATRFIQRSPVTLLR 769

  Fly   779 SSLITPIFQCALIACSLDHREANSSVMKFFINLLVWGRSNN------HSRNTECR-PLVVELASQ 836
            |.::.||.|.|:.:.:||||:||||||:|..:|:..|.:|:      |..:.|.| .|:.::.||
Mouse   770 SQVVIPILQWAIASTTLDHRDANSSVMRFLRDLIHTGVANDLSVFLQHEEDFELRKELIGQVMSQ 834

  Fly   837 HGGALVMNLIQASVFQLHSYMLVDVAEVLHELKQVVGNERMQPFLAQALEALPKKNSGGYVTATQ 901
            .|..||..|:....|.|..|.|.||||||.|:.| |.......:|..:|:.|||:.:.|.||.|.
Mouse   835 LGQQLVSQLLHTCCFCLPPYTLPDVAEVLWEIMQ-VDRPTFCRWLENSLKGLPKETTVGAVTVTH 898

  Fly   902 QQLDEFSSTVLRADTTKAISQALKTFTRLFR 932
            :||.:|...|..|:..|.:..||:.||||||
Mouse   899 KQLTDFHKQVTSAEECKQVCWALRDFTRLFR 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnpo-SR	NP_001259961.1	IBN_N	28..94	CDD:281761	36/65 (55%)
		Xpo1	100..248	CDD:285575	57/153 (37%)
		HEAT repeat	427..454	CDD:293787	11/26 (42%)
		HEAT repeat	462..496	CDD:293787	13/33 (39%)
		HEAT repeat	506..531	CDD:293787	11/24 (46%)
Tnpo3	NP_001334008.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833067
Domainoid	1	1.000	574	1.000	Domainoid score	I223
eggNOG	1	0.900	-	-		E1_KOG2081
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40848
Inparanoid	1	1.050	754	1.000	Inparanoid score	I562
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55013
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004702
OrthoInspector	1	1.000	-	-		oto92310
orthoMCL	1	0.900	-	-		OOG6_103041
Panther	1	1.100	-	-	LDO	PTHR12363
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1966
SonicParanoid	1	1.000	-	-		X5042
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790