DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tnpo-SR and Tnpo3

DIOPT Version :9

Sequence 1:	NP_001259961.1	Gene:	Tnpo-SR / 33465	FlyBaseID:	FBgn0031456	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_001100057.1	Gene:	Tnpo3 / 296954	RGDID:	1308938	Length:	923	Species:	Rattus norvegicus

Alignment Length:	935	Identity:	398/935 - (42%)
Similarity:	592/935 - (63%)	Gaps:	25/935 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SVDVVYQAISALFQGNNPKEQEKANKWLQDFQKSIYSWTIADELLHQKRDLHANYFAAQTMRNKI 69
            ::.:||||:.||:...:|..:|:|:.||.:.|:|:::|.|:|:||..::|:.:.|||||||:.||
  Rat     7 TLQLVYQAVQALYHDPDPSGKERASFWLGELQRSVHAWEISDQLLQIRQDVESCYFAAQTMKMKI 71

  Fly    70 QNSFSELPPHTHESLRDSLITHIGQIDEQTDNVIVTQLSLAVADLALLMASWREPINDLL----- 129
            |.||.|||..:|.||||||:|||..:.:.:. ||||||:||:|||||.|.||:..:..|:
  Rat    72 QTSFYELPTDSHASLRDSLLTHIQNLKDLSP-VIVTQLALAIADLALQMPSWKGCVQTLVEKYSN 135

  Fly   130 -VTLAPHQCAIWPLLEVLKVLPEEIDSRYLRLGANRREEVHKQLDASAECVLKFLCMCLQREDLD 193
             ||..|.      |||:|.|||||:.||.||:|||||.|:.:.|...:..|:..|..|:::...|
  Rat   136 DVTSLPF------LLEILTVLPEEVHSRSLRIGANRRTEIIEDLAFYSSTVVSLLMTCVEKAGTD 194

  Fly   194 QQRVWNAALRTYSAWLVIHAFPVSHVYNNALTQLAFRLLSLPETSGKLHDNATECVCALLSCINT 258
            ::.:.. ..|...:|..:.....:.:.||.|..|.|.:|...:||..||:.|::|||:.|..|..
  Rat   195 EKMLMK-VFRCLGSWFNLGVLDSNFMANNKLLALLFEVLQQDKTSSNLHEAASDCVCSALYAIEN 258

  Fly   259 RQDGASDPESSFEAQLFGAVCMLETPYHLSVAHEDTDKTINYCRIFTSLCDAFFYDLLADAQKPH 323
                 .:.......|||..|..|||.||::||.||.||.:|||||||.||:.|...::....:..
  Rat   259 -----VETNLPLAMQLFQGVLTLETAYHMAVAREDLDKVLNYCRIFTELCETFLEKIVCTPGQGL 318

  Fly   324 YSLKGLDLVLLCVGHFDYEVAEITFHLWYKLSEDLFQRNEDKLTVLFRPHIERLISALFRHSQME 388
            ..|:.|:|:|:|.||..|||.||:|:.||:|.|.|::.|::.:..:|:.:|:||:.||.||.|:|
  Rat   319 GDLRTLELLLICAGHPQYEVVEISFNFWYRLGEHLYKTNDEVIHSIFKAYIQRLLHALARHCQLE 383

  Fly   389 SDHDGLIEENNNFFDFRRKVSDLIKDVAFIVGSGACFKQMFHILQAPETTWESTEAALFIMQNVA 453
            .||:|:.||.::|.:||.:||||:||:.|::||..||.|::..|:.....||.|||.||||..:|
  Rat   384 PDHEGVPEETDDFGEFRMRVSDLVKDLIFLIGSMECFAQLYSTLKEGNPPWEVTEAVLFIMAAIA 448

  Fly   454 KNILPDENEVIPKVVEAILNMSEQTHIAVRYTAILLIGELCDWIENHPESLEAVLNFLLYALQQK 518
            |::.|:.|..:.:|:|.::::.|..|.|||||:|.|:||:.:.::.:|:.|:.||.:|:..|.:|
  Rat   449 KSVDPENNPTLVEVLEGVVHLPETVHTAVRYTSIELVGEMSEVVDRNPQFLDPVLGYLMKGLCEK 513

  Fly   519 NGLAPAAAIALTSICSACRQKMVCHISGLVEIARSLDSFQINNDVAIGLLKGISLILTRLPREQL 583
             .||.|||.|:.:|||.||..|..|.:||:|||.|||||.::.:.|:|||||.:|:|.|||.:::
  Rat   514 -PLASAAAKAIHNICSVCRDHMAQHFNGLLEIAHSLDSFMLSPEAAVGLLKGTALVLARLPLDKI 577

  Fly   584 QPALREIVGFQLQPLAQLVDSTGSTPQKGERTDPVYWIDRACAIIRHTNPDVPDNVEHPTVAILN 648
            ...|.|:...|:..|.:|:   ...|..|..:||..::||...|.|||||.|.:...||...::.
  Rat   578 TECLSELCSVQVMALKKLL---SQEPSNGISSDPTVFLDRLAVIFRHTNPIVENGQTHPCQKVIQ 639

  Fly   649 DAWQLISRVMDKYQSDLRIMERTCRLIRYGIRMVRKQAMMLVEPLIKQMVVLYSVQHHSCFLYVG 713
            :.|.::|..::|:::|.||:||.||.:|:.:|.|.|.:..|::||:.|||.:|.|..||||||:|
  Rat   640 EIWPVLSETLNKHRADNRIVERCCRCLRFAVRCVGKGSAALLQPLVTQMVNVYHVHQHSCFLYLG 704

  Fly   714 SILVDEFAKSSECIGGLLEMLQAFIEPTFGLLQMENGLKNNPDTVDDFFRLASRYLDCCPHQLLQ 778
            ||||||:.....|..|||:||||...|||.||:.:|||:|:||||||.||||:|::...|..||:
  Rat   705 SILVDEYGMEEGCRQGLLDMLQALCIPTFQLLEQQNGLQNHPDTVDDLFRLATRFIQRSPVTLLR 769

  Fly   779 SSLITPIFQCALIACSLDHREANSSVMKFFINLLVWGRSNNHSRNTECR-PLVVELASQHGGALV 842
            |.::.||.|.|:.:.:||||:||||||:|..:|:..|.:|:|..:.|.| .|:.::..|.|..||
  Rat   770 SQVVIPILQWAIASTTLDHRDANSSVMRFLRDLIHTGVANDHEEDFEVRKELIGQVMDQLGQQLV 834

  Fly   843 MNLIQASVFQLHSYMLVDVAEVLHELKQVVGNERMQPFLAQALEALPKKNSGGYVTATQQQLDEF 907
            ..|:....|.|..|.|.||||||.|:.| |.......:|..:|:.|||:.:.|.||.|.:||.:|
  Rat   835 SQLLHTCCFCLPPYTLPDVAEVLWEIMQ-VDRPTFCRWLENSLKGLPKETTVGAVTVTHKQLTDF 898

  Fly   908 SSTVLRADTTKAISQALKTFTRLFR 932
            ...|..|:..|.:..||:.||||||
  Rat   899 HKQVTSAEECKQVCWALRDFTRLFR 923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnpo-SR	NP_001259961.1	IBN_N	28..94	CDD:281761	36/65 (55%)
		Xpo1	100..248	CDD:285575	57/153 (37%)
		HEAT repeat	427..454	CDD:293787	11/26 (42%)
		HEAT repeat	462..496	CDD:293787	13/33 (39%)
		HEAT repeat	506..531	CDD:293787	11/24 (46%)
Tnpo3	NP_001100057.1	IBN_N	33..96	CDD:197981	35/62 (56%)
Tnpo3	NP_001100057.1	Xpo1	121..248	CDD:400614	43/133 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336647
Domainoid	1	1.000	571	1.000	Domainoid score	I214
eggNOG	1	0.900	-	-		E1_KOG2081
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40848
Inparanoid	1	1.050	754	1.000	Inparanoid score	I537
OMA	1	1.010	-	-		QHG55013
OrthoDB	1	1.010	-	-		D179626at33208
OrthoFinder	1	1.000	-	-		FOG0004702
OrthoInspector	1	1.000	-	-		oto95878
orthoMCL	1	0.900	-	-		OOG6_103041
Panther	1	1.100	-	-	LDO	PTHR12363
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5042
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770