DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tnpo-SR and kap111

DIOPT Version :9

Sequence 1:	NP_001259961.1	Gene:	Tnpo-SR / 33465	FlyBaseID:	FBgn0031456	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_593051.1	Gene:	kap111 / 2541467	PomBaseID:	SPAC22G7.02	Length:	990	Species:	Schizosaccharomyces pombe

Alignment Length:	1078	Identity:	195/1078 - (18%)
Similarity:	377/1078 - (34%)	Gaps:	264/1078 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDTYSVDVVYQAISALFQGN-NPKEQEKANKWLQDFQKSIYSWTIADELLHQKRDLHANYFAAQT 64
            ||...:....:.:..|:.|: :|.......|.||..|:|...|.|...:| |.:|::..:|.|.|
pombe     1 MDGNEIAHAKKLVYDLYSGSLSPSAIAATEKELQKAQRSQQGWNIGLFML-QSKDVYEQFFGALT 64

  Fly    65 MRNKIQNSFSELPPHTHESLRD-SLITHIGQI------DEQTDNVIVTQLSLAVADLALLMASWR 122
            ::.||....        |:|.| .|:....|:      |:....::..::...:|.|.:.....:
pombe    65 LQMKINTQL--------ETLSDKDLVQLFVQLLQKLLWDDGLPALVERKVICTLASLTIKYELEK 121

  Fly   123 EPINDLLVTLAPHQCAIWPLLE----------VLKVLPEEIDSRYLRLGANRREEVHKQLDAS-- 175
            :....|.|.    .|.....||          ||..|.....||..:|.|:...|:..:|..|
pombe   122 KEEASLKVI----YCLFCNKLEFFNADMNAASVLNNLFPPASSRNAQLTASYINELLLELSFSIY 182

  Fly   176 ----------------AECVLKFLCMCLQREDLDQQRVWNAA--------LRTYSAWLVIHAFPV 216
                            :..::..|........||..:..|.|        :...|::|...:..|
pombe   183 TKENEDALFNNVFRPCSNIIVSVLVFIFTNYSLDLSKEKNVAALEEALNCMIAISSYLAKASVSV 247

  Fly   217 SHVYNNALTQ---LAFRLLSLPETSGKLHDNATECVCALLSCINTRQDGASDPESSFEAQ--LFG 276
            ..|. .|.|:   |....::|.|.|.|    |..|:..||:           ..|:|..|  :..
pombe   248 QSVL-PAFTECMDLTVNCIALDEVSEK----AMNCLADLLA-----------NYSNFITQPTIER 296

  Fly   277 AVCMLETPY---HLSVAHEDTD----KTINYCRIFTSLCDAFFYDLLADAQKPHYSLKGLDLVLL 334
            ...:|..|:   ||....||.|    ...::..|.....:|....::...|: ..|::.|.::..
pombe   297 LWTILTGPWGETHLQQELEDPDSGEENDYSFLNIVIGFAEAMLPQIIDHIQE-EKSIRLLYILAS 360

  Fly   335 CVGHFDYEVAE-----ITFHLWYKLSEDLFQR------NEDKL------TVLFRPHIERLISALF 382
            .:....|.:.|     .|...|..|.||....      ::|::      :|:.:...:.|:.:..
pombe   361 LLSFPGYAIVEEKVSWRTLEFWTTLIEDFSMSKAATDPSKDEIFKQIAFSVVEKAWWKMLLPSPE 425

  Fly   383 RHSQMESDHDGLIEENNNFFDFRRKVSDLIKDVAFIVGSGACFKQMFHILQAPETTWE------- 440
            :.:...|      ...::|..:||.:.||::      .|.:.|.:..:.:..  ||.|
pombe   426 QWNSWPS------SSRDSFNSYRRDLGDLLE------SSYSIFGERLYAMYI--TTIENFFSDGT 476

  Fly   441 ----STEAALFIMQNVAKNILPDENEVIPKVVEAILNMSEQTHIAVRYTAI----------LLIG 491
                |.|.:.:.:..:.:.   |.|:  ...::|.|....:|..|::.:|.          .|:.
pombe   477 GSPQSLEVSFYCLCCILEY---DTND--SDTLDAWLTRLFETSFAIKASAFQNPQLLKTCSQLLS 536

  Fly   492 ELCDWIENHPESLEAVLNFLLYALQ-QKNGLAPAAAIALTSICSACRQKMVCHISG--------- 546
            ....:::|||:.|...|..|..||. .:..:....:.::.::|:.|...::..|.|
pombe   537 SCSCFLQNHPQYLNISLPVLFDALHISETSIQMTVSRSIHTLCTTCASHLLTEIDGFMAVVEELT 601

  Fly   547 --LVEIARSLDSFQINNDVAIGLLKGISLILTRLPR------EQLQPA---------------LR 588
              ||.:...|:....:.......::.|.|.::.|.|      .||||:               |:
pombe   602 PKLVYVPSVLEKIYSSVGYVTQRIEDIELRISYLMRLLNCILAQLQPSLYPNLEIFENVLKSCLQ 666

  Fly   589 EIVGFQL--QPLAQ--LVDSTGSTPQKGERTDPVYWIDRACAIIRHTNPDVPDNVEHPTVAILND 649
            .:.|..|  .|:.:  ::|...||      .:..:| .::|..          ..:...::.|..
pombe   667 SVAGVALSQSPIGESPIIDVEQST------QETTFW-QQSCIA----------EFQAKLISFLTH 714

  Fly   650 AWQLISRVMDKYQSDLRIMERTCRLIRYGIRMVRKQAMMLVEPLIKQMVVLYSVQHH-------- 706
            :..:..:..|       ::...|:::..|:..        |||....:.::.::|:.
pombe   715 SESMALQYSD-------VVGLICKIMIAGLNE--------VEPSPFSLPIVTTIQYFCDRFTEFP 764

  Fly   707 -SCFLYVGS-ILVDEFAKSSECIGGLLEMLQAFIEPTFGLLQMENGLKNNPDTVDDFFRLASRYL 769
             :..|.:|| ||...:.::......|::|..: |:.:..::. |....||.|...:.:...|..|
pombe   765 AAVLLTLGSAILTCPYGQTDIIDKVLIDMCSS-IQNSVVIIN-EESFMNNIDITVELYHFFSIIL 827

  Fly   770 DCCPH--QLLQSSLITPIFQCALIACSLDHREANSSVMKFFINLLVWGRS---NNHSR--NTECR 827
            ...|.  :.:.......|...|:.......|...|:..:|.|:.:...:|   |.|:.  |....
pombe   828 QKHPSFLETMYPDFTQLILNRAINLLGKPERLLESAAGQFIISFITSEKSDLLNTHTDFVNAIRS 892

  Fly   828 PLVVELASQHGGALVMNLIQASVFQLHSYMLVDVAEVLHELKQVVGNERMQPF------LAQAL- 885
            ||:.::....||    |..::|               |..|..::|..:.|.|      |.|:|
pombe   893 PLIAKILLGFGG----NASRSS---------------LPLLSDILGKLKAQNFSATRACLTQSLE 938

  Fly   886 -EALPKKNSGGYVTATQQQLDEFSSTVLRADTTKAISQ 922
             |..|.:|....:..      .|.:.:|:|.....:.|
pombe   939 EEGFPSRNVSNEIKR------RFLTDLLKARIKDKVKQ 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnpo-SR	NP_001259961.1	IBN_N	28..94	CDD:281761	19/66 (29%)
		Xpo1	100..248	CDD:285575	34/186 (18%)
		HEAT repeat	427..454	CDD:293787	5/37 (14%)
		HEAT repeat	462..496	CDD:293787	6/43 (14%)
		HEAT repeat	506..531	CDD:293787	4/25 (16%)
kap111	NP_593051.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12363
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010