DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tnpo-SR and TNPO3

DIOPT Version :9

Sequence 1:	NP_001259961.1	Gene:	Tnpo-SR / 33465	FlyBaseID:	FBgn0031456	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_001369145.1	Gene:	TNPO3 / 23534	HGNCID:	17103	Length:	957	Species:	Homo sapiens

Alignment Length:	969	Identity:	398/969 - (41%)
Similarity:	592/969 - (61%)	Gaps:	59/969 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SVDVVYQAISALFQGNNPKEQEKANKWLQDFQKSIYSWTIADELLHQKRDLHANYFAAQTMRNKI 69
            ::.:||||:.||:...:|..:|:|:.||.:.|:|:::|.|:|:||..::|:.:.|||||||:.||
Human     7 TLQLVYQAVQALYHDPDPSGKERASFWLGELQRSVHAWEISDQLLQIRQDVESCYFAAQTMKMKI 71

  Fly    70 QNSFSELPPHTHESLRDSLITHIGQIDEQTDNVIVTQLSLAVADLALLMASWREPINDLL----- 129
            |.||.|||..:|.||||||:|||..:.:.:. ||||||:||:|||||.|.||:..:..|:
Human    72 QTSFYELPTDSHASLRDSLLTHIQNLKDLSP-VIVTQLALAIADLALQMPSWKGCVQTLVEKYSN 135

  Fly   130 -VTLAPHQCAIWPLLEVLKVLPEEIDSRYLRLGANRREEVHKQLDASAECVLKFLCMCLQREDLD 193
             ||..|.      |||:|.|||||:.||.||:|||||.|:.:.|...:..|:..|..|:::...|
Human   136 DVTSLPF------LLEILTVLPEEVHSRSLRIGANRRTEIIEDLAFYSSTVVSLLMTCVEKAGTD 194

  Fly   194 QQRVWNAALRTYSAWLVIHAFPVSHVYNNALTQLAFRLLSLPETSGKLHDNATECVCALLSCINT 258
            ::.:.. ..|...:|..:.....:.:.||.|..|.|.:|...:||..||:.|::|||:.|..|..
Human   195 EKMLMK-VFRCLGSWFNLGVLDSNFMANNKLLALLFEVLQQDKTSSNLHEAASDCVCSALYAIEN 258

  Fly   259 RQDGASDPESSFEAQLFGAVCMLETPYHLSVAHEDTDKTINYCRIFTSLCDAFFYDLLADAQKPH 323
                 .:.......|||..|..|||.||::||.||.||.:|||||||.||:.|...::....:..
Human   259 -----VETNLPLAMQLFQGVLTLETAYHMAVAREDLDKVLNYCRIFTELCETFLEKIVCTPGQGL 318

  Fly   324 YSLKGLDLVLLCVGHFDYEVAEITFHLWYKLSEDLFQRNEDKLTVLFRPHIERLISALFRHSQME 388
            ..|:.|:|:|:|.||..|||.||:|:.||:|.|.|::.|::.:..:|:.:|:||:.||.||.|:|
Human   319 GDLRTLELLLICAGHPQYEVVEISFNFWYRLGEHLYKTNDEVIHGIFKAYIQRLLHALARHCQLE 383

  Fly   389 SDHDGLIEENNNFFDFRRKVSDLIKDVAFIVGSGACFKQMFHILQAPETTWESTEAALFIMQNVA 453
            .||:|:.||.::|.:||.:||||:||:.|::||..||.|::..|:.....||.|||.||||..:|
Human   384 PDHEGVPEETDDFGEFRMRVSDLVKDLIFLIGSMECFAQLYSTLKEGNPPWEVTEAVLFIMAAIA 448

  Fly   454 KNILP----------------------------------DENEVIPKVVEAILNMSEQTHIAVRY 484
            |::.|                                  :.|..:.:|:|.::.:.|..|.||||
Human   449 KSVDPKKPFSNAVCRHSLLFGQNITSEISNCEYLPPVLRENNPTLVEVLEGVVRLPETVHTAVRY 513

  Fly   485 TAILLIGELCDWIENHPESLEAVLNFLLYALQQKNGLAPAAAIALTSICSACRQKMVCHISGLVE 549
            |:|.|:||:.:.::.:|:.|:.||.:|:..|.:| .||.|||.|:.:|||.||..|..|.:||:|
Human   514 TSIELVGEMSEVVDRNPQFLDPVLGYLMKGLCEK-PLASAAAKAIHNICSVCRDHMAQHFNGLLE 577

  Fly   550 IARSLDSFQINNDVAIGLLKGISLILTRLPREQLQPALREIVGFQLQPLAQLVDSTGSTPQKGER 614
            ||||||||.::.:.|:|||||.:|:|.|||.:::...|.|:...|:..|.:|:   ...|..|..
Human   578 IARSLDSFLLSPEAAVGLLKGTALVLARLPLDKITECLSELCSVQVMALKKLL---SQEPSNGIS 639

  Fly   615 TDPVYWIDRACAIIRHTNPDVPDNVEHPTVAILNDAWQLISRVMDKYQSDLRIMERTCRLIRYGI 679
            :||..::||...|.|||||.|.:...||...::.:.|.::|..::|:::|.||:||.||.:|:.:
Human   640 SDPTVFLDRLAVIFRHTNPIVENGQTHPCQKVIQEIWPVLSETLNKHRADNRIVERCCRCLRFAV 704

  Fly   680 RMVRKQAMMLVEPLIKQMVVLYSVQHHSCFLYVGSILVDEFAKSSECIGGLLEMLQAFIEPTFGL 744
            |.|.|.:..|::||:.|||.:|.|..||||||:|||||||:.....|..|||:||||...|||.|
Human   705 RCVGKGSAALLQPLVTQMVNVYHVHQHSCFLYLGSILVDEYGMEEGCRQGLLDMLQALCIPTFQL 769

  Fly   745 LQMENGLKNNPDTVDDFFRLASRYLDCCPHQLLQSSLITPIFQCALIACSLDHREANSSVMKFFI 809
            |:.:|||:|:||||||.||||:|::...|..||:|.::.||.|.|:.:.:||||:||.|||:|..
Human   770 LEQQNGLQNHPDTVDDLFRLATRFIQRSPVTLLRSQVVIPILQWAIASTTLDHRDANCSVMRFLR 834

  Fly   810 NLLVWGRSNNHSRNTECR-PLVVELASQHGGALVMNLIQASVFQLHSYMLVDVAEVLHELKQVVG 873
            :|:..|.:|:|..:.|.| .|:.::.:|.|..||..|:....|.|..|.|.||||||.|:.| |.
Human   835 DLIHTGVANDHEEDFELRKELIGQVMNQLGQQLVSQLLHTCCFCLPPYTLPDVAEVLWEIMQ-VD 898

  Fly   874 NERMQPFLAQALEALPKKNSGGYVTATQQQLDEFSSTVLRADTTKAISQALKTFTRLFR 932
            ......:|..:|:.|||:.:.|.||.|.:||.:|...|..|:..|.:..||:.||||||
Human   899 RPTFCRWLENSLKGLPKETTVGAVTVTHKQLTDFHKQVTSAEECKQVCWALRDFTRLFR 957

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnpo-SR	NP_001259961.1	IBN_N	28..94	CDD:281761	36/65 (55%)
		Xpo1	100..248	CDD:285575	57/153 (37%)
		HEAT repeat	427..454	CDD:293787	11/26 (42%)
		HEAT repeat	462..496	CDD:293787	13/33 (39%)
		HEAT repeat	506..531	CDD:293787	11/24 (46%)
TNPO3	NP_001369145.1	IBN_N	33..96	CDD:197981	35/62 (56%)
TNPO3	NP_001369145.1	Xpo1	121..248	CDD:400614	43/133 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142947
Domainoid	1	1.000	570	1.000	Domainoid score	I229
eggNOG	1	0.900	-	-		E1_KOG2081
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40848
Inparanoid	1	1.050	751	1.000	Inparanoid score	I572
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55013
OrthoDB	1	1.010	-	-		D179626at33208
OrthoFinder	1	1.000	-	-		FOG0004702
OrthoInspector	1	1.000	-	-		oto88743
orthoMCL	1	0.900	-	-		OOG6_103041
Panther	1	1.100	-	-	LDO	PTHR12363
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1966
SonicParanoid	1	1.000	-	-		X5042
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800