DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tnpo-SR and T16G12.6

DIOPT Version :9

Sequence 1:	NP_001259961.1	Gene:	Tnpo-SR / 33465	FlyBaseID:	FBgn0031456	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_001366683.1	Gene:	T16G12.6 / 176420	WormBaseID:	WBGene00011807	Length:	949	Species:	Caenorhabditis elegans

Alignment Length:	1027	Identity:	200/1027 - (19%)
Similarity:	368/1027 - (35%)	Gaps:	319/1027 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 YFAAQTMRNKIQNSFSELPPHTHESLRDSLITHIGQIDE-------QTDNVIVTQLSLAVADLAL 116
            ||.|..:.:.|:....|.  ..:|:::.||.|.:  ||.       ||.:|: .:||.|:|..:|
Worm    65 YFGAVALYDVIRVRSEEC--IANEAVQLSLKTFL--IDSLKSGAYAQTTSVL-NKLSAALALFSL 124

  Fly   117 LMAS--WREPINDLLVTLA--PHQCAIWPLLEVLKVLPEEIDSRYLRLGANRREEVHKQLDASAE 177
            ....  |..|:.||..|||  |.     .||:||..:..|..  ::.:...:|.::..:|...:|
Worm   125 YCVPDLWPTPVQDLTPTLAGSPE-----ILLKVLSDMAAEFS--HVTMPLTQRSKLKGELHKFSE 182

  Fly   178 CVLKFLCMCLQRED---LDQQRVWNAALRTYSAWLVIHAFPV---SHVYNNAL-------TQLAF 229
            .::..|.:.|:..|   :.:|    ||:.....||.:....:   :||.::.|       |.||
Worm   183 NIISVLAVVLRGGDTSSITKQ----AAVECVEQWLRLPGMALDQWTHVLSDVLGAVVQDCTALA- 242

  Fly   230 RLLSLPETSGKLHDNAT--ECVCALLSCINT----RQDGASDPESSFEAQLFGAVCML---ETPY 285
            .:|.:...:.:.|.|:|  ..:|..: |.|.    .::..:|..|...|.|..|.|.:   ..|.
Worm   243 SILDIIAENDEFHRNSTLIISICQYI-CFNVSGKIEEELGADASSEEIATLVAATCSVSENSVPT 306

  Fly   286 HLSVAHE--DTDKTINYCR----------------IFTSLCDAFFYDLLADAQKPHYSLKGLDL- 331
            .:..|.:  |::..|...:                |.:.|...:|..|..:..:...|  |:.:
Worm   307 LVECAAQGGDSELVIRLSQVMQVLANMQGQYPLEEIVSDLPSIYFITLRTEIMQTINS--GIQID 369

  Fly   332 --VLLCVGHFDYEVAEITF--------HLWYKLSEDLFQRNEDKLTVLFRPHIERLISALFRHSQ 386
              :|..:|....::.|::.        .:|  ||.:|.:|.:.:               .:|.::
Worm   370 KQILSQIGQIYAKILEMSIKKLAFPSKEIW--LSWNLEEREQFE---------------SYRKTR 417

  Fly   387 MESDHDGLIEENNNFFDFRRKVSDLIKDVAFIVGSGACFKQMFHILQAPETTWESTEAALFIMQN 451
            .|:.:|..........||      |.:.:...:|:|..               ..||:.:|..:.
Worm   418 SEASYDSYHFSAAGTLDF------LNQTLEQALGAGDV---------------NRTESCIFQWEC 461

  Fly   452 VAKNILPDENEVIPKVVEAILNMSEQTHIAVRYTAILLIGELC--DWIENHPESLEA-------- 506
            ||..:  .|.:                     |||||...|:|  ..:...|.|..:
Worm   462 VADYL--GETD---------------------YTAILKCLEMCASSQLSAPPPSTSSSSSDKIDI 503

  Fly   507 -------VLNFLLYALQ---QKNGLAPAAAIALTSICSACRQKMVCHISGLV-EIARSLDSFQ-- 558
                   .|..|.|:|.   |::..|.....||..|       ::.::|..: .:.:::|:.|
Worm   504 DLNRRGETLMRLFYSLSHLIQEHEQAKELECALIPI-------ILTYVSTRIPSVRQAIDTLQKF 561

  Fly   559 ----------------------INNDVA-----IGLLKGISLILT-RLPREQLQPALREIVGFQL 595
                                  .|:..|     :..||.|..:|: |.|.|.:     :|:|
Worm   562 SEDRPESLDIIGEQISTTCYEFFNSSNARDSDRLAALKCIGYVLSRRKPSETM-----KIIG--- 618

  Fly   596 QPLAQL-VDSTGSTPQKGERTDPVYWIDRACAIIRH-TN------PDVPDNVEHPTVAILNDAWQ 652
            |.|:|. ::..|...|...|. ..:.|:...|:... ||      ..:.:|.|.||:.      |
Worm   619 QILSQQNINEPGIDDQTRHRR-YAFQINTFSALFASLTNKKDSNSTSLGENDEEPTIV------Q 676

  Fly   653 LISRVMDKYQ------SDL------RIMERTCRLIRYGIRMVRKQAMMLVEPLIKQMVVLYSVQH 705
            |:...:..::      |.|      .:::..|:.:|..:..:.:..:....|.|      .|:.:
Worm   677 LLCEAIPVFETLCSGGSGLDGSNSGSLIQEVCKAVRSALTSLPEHYLPSFFPFI------VSLLN 735

  Fly   706 HSCFLYVGSILVDEFAKSS--ECIGGL--LEMLQAFIEPTFGLLQMENGLKNNPDTVDDFFRLAS 766
            .|.|:....|.....|||:  :| |.|  ::|..||.:   .:|..|..:::  ..||::.:|.
Worm   736 SSLFVTESVIAACALAKSTVLQC-GSLVGVDMANAFAQ---WILAFEQHVES--PQVDEYLQLI- 793

  Fly   767 RYLDCCPHQLLQSS--LITPI-------FQCALIACSLDHREANSSVMKFFINLLVWGRSNNHSR 822
                   :|:::.:  :|...       ||.:|..||             ||.|       |.|.
Worm   794 -------YQVVRKNWKMIRKFPDPSMAAFQSSLKICS-------------FIIL-------NSSV 831

  Fly   823 NTECR---PLVVELA---------------SQHGGALVM--------NLIQASVFQLHSYMLVDV 861
            .||.|   .::..||               :::|..|:.        .|::.:|..|...:|...
Worm   832 PTEVRSASQILAALATYATSHDDVAMKSTFAENGPILIRAVFRRVQGELMRPTVEALADILLFYF 896

  Fly   862 AEVLHELKQVVGNERMQPFLAQALEALPKKNSGGYVTATQQQLDEFSSTVLR 913
            .|...:.:.::..|   |:...||.....:..|......||.: .|:...||
Worm   897 KEFTTDTRTLISGE---PYGTSALVTSMFREIGNPRNFKQQTI-RFNLAALR 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnpo-SR	NP_001259961.1	IBN_N	28..94	CDD:281761	9/34 (26%)
		Xpo1	100..248	CDD:285575	40/166 (24%)
		HEAT repeat	427..454	CDD:293787	4/26 (15%)
		HEAT repeat	462..496	CDD:293787	7/35 (20%)
		HEAT repeat	506..531	CDD:293787	8/42 (19%)
T16G12.6	NP_001366683.1	Xpo1	111..>214	CDD:400614	29/114 (25%)
T16G12.6	NP_001366683.1	Importin_rep	393..>414	CDD:408544	5/37 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910