DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tnpo-SR and Ipo13

DIOPT Version :9

Sequence 1:	NP_001259961.1	Gene:	Tnpo-SR / 33465	FlyBaseID:	FBgn0031456	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	NP_446230.2	Gene:	Ipo13 / 116458	RGDID:	620071	Length:	963	Species:	Rattus norvegicus

Alignment Length:	983	Identity:	231/983 - (23%)
Similarity:	431/983 - (43%)	Gaps:	105/983 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 YSVDVVYQAISALFQGNNPKEQEKANKWLQDFQKSIYSWTIADELLHQKRDLHANYFAAQTMRNK 68
            ::|:.|.:|:..|:...|.:.:..|.|||...|.|..:|..:.:||...:.....||.|..:..|
  Rat    21 FTVENVEKALHQLYYDPNIENKNLAQKWLMQAQVSPQAWHFSWQLLQPDKVPEIQYFGASALHIK 85

  Fly    69 IQNSFSELPPHTHESLRDSLITHIGQIDEQTDNVIVTQLSLAVADLALLMA--SWREPINDLLVT 131
            |...:|::|...:|||:..|.|.|.:. .....:::|:|.:|:|.|||.|.  :|...:.|::..
  Rat    86 ISRYWSDIPTDQYESLKAQLFTQITRF-ASGSKIVLTRLCVALASLALSMMPDAWPCAVADMVRL 149

  Fly   132 LAPHQCAI------WPLLEVLKVLPEEIDSRYLRLGANRREEVHKQLDASAECVLKFLCMCLQRE 190
            .......:      ..|||:|.|||||..:.  ||...|:..|...|......|...|...||:.
  Rat   150 FQAEDSPVDSQGRCLALLELLTVLPEEFQTS--RLPQYRKGLVRASLAVECGAVFPLLEQLLQQP 212

  Fly   191 DLD---QQRVWNAALRTYSAWLVIHAFPVSHVYNNALTQLAFRLLSLPETSGKLHDNATECVCAL 252
            ...   :|:|    |:.:|:|:.:.. |:...  .||.|.||..|.    ..:|.|::.|.:...
  Rat   213 SSPSCVRQKV----LKCFSSWVQLEV-PLQDC--EALIQAAFAALQ----DSELFDSSVEAIVNA 266

  Fly   253 LS------CINTRQDGASDPESSFEAQLFGAVCMLETPYHLSVAHEDTDKTINYCRIFTSLCDAF 311
            :|      .:||.            .:|...|..|:.....:|.:.|.:.:...|||..:|.:..
  Rat   267 ISQPDAQRYVNTL------------LKLIPLVLGLQEQLRQAVQNGDMETSHGICRIAVALGENH 319

  Fly   312 FYDLLADAQKPHYSLKGLDLVLLCV---GHF--DYEVAEITFHLWYKLSEDLFQRNEDKLTV--- 368
            ...||...:.....|..:::::.|.   ||:  :...:.:|...||.|.:|:.....:|..|
  Rat   320 SRALLDQVEHWQSFLALVNMIMFCTGIPGHYPVNETTSSLTLTFWYTLQDDILSFEAEKQAVYQQ 384

  Fly   369 LFRPHIERLISALFRHSQMESDHD-GL--IEENNNFFDFRRKVSDLIKDVAFIVGS---GACFKQ 427
            ::||...:|:..|...:|..||.: |.  .:|...|..:|..:||.:..|..::|:   ...:.:
  Rat   385 VYRPVYFQLVDVLLHKAQFPSDEEYGFWSSDEKEQFRIYRVDISDTLMYVYEMLGAELLSNLYDK 449

  Fly   428 MFHILQAPET--TWESTEAALFIMQNVAKNILPDENEVIPKVVEAILNMSEQTHIAVRYTAILLI 490
            :..:|.:.|.  :|:.|||.|:..|::|:.|..:.::|:|.::..|..:| .:::.:..|.:..|
  Rat   450 LGRLLTSSEEPYSWQHTEALLYGFQSIAETIDVNYSDVVPGLIGLIPRIS-ISNVQLADTVMFTI 513

  Fly   491 GELCDWIENHPESLEAVLNFLLYALQQKNGLAPAAAIALTSICSACRQKMVCHISGLVEIARSLD 555
            |.|.:|:.:||..:.:||..:|:||.... |:.::...|..||..|:..:..:.:.:|.:::.:.
  Rat   514 GALSEWLADHPVMINSVLPLVLHALGNPE-LSVSSVSTLKKICRECKYDLPPYAANIVAVSQDVL 577

  Fly   556 SFQIN-NDVAIGLLKGISLILTRLPREQLQPALREIVGFQLQPLAQLVDSTGSTPQK-------G 612
            ..||: ....:.|::.:..:|:.|..|::...|..::...:|.|.:|.:...:...|       |
  Rat   578 MKQIHKTSQCMWLMQALGFLLSALQVEEILKNLHSLISPYIQQLEKLAEEIPNPSNKLAIVHILG 642

  Fly   613 ERTDPVYWIDRACAIIRHTNPD-----VPDNVEHPTVAILNDAWQLISRVMDKYQSDLRIMERTC 672
            ..::....:|.:.....|..|:     ||.. .:|.|.:|...:|||.:|:.|:.||.:::|..|
  Rat   643 LLSNLFTTLDVSHHEDDHEGPELRKLPVPQG-PNPVVVVLQQVFQLIQKVLSKWLSDAQVVEAVC 706

  Fly   673 RLIRYGIRMVRKQAMMLVEPLIKQMVVLYSVQHHSCFLYVGSILVDEFAKSSECIGGLLEMLQAF 737
            .:....::.:......:|..|.:.:..:||....:..|.:...||..||........:..:....
  Rat   707 AIFEKSVKTLLDDFAPMVPQLCEMLGRMYSTVPQASALDLTRQLVHIFAHEPAHFPPIEALFLLV 771

  Fly   738 IEPTFGLLQMENGLKNNPDTVDDFFRLASRYLDCCPHQLLQSSL--ITPIFQCALIACSLDHREA 800
            ...|..|.|  .|.:::||.||.|.:|.::.|...| .|.|...  :..:||||::|........
  Rat   772 TSVTLSLFQ--QGPRDHPDIVDSFMQLLAQALKRKP-DLFQCERLDVKAVFQCAVLALKFPEAPT 833

  Fly   801 NSSVMKFFINLLVWGRSNNHSRNTECRPL--VVELASQHGGALVMNLIQASVFQLHSYMLVDVAE 863
            ..:...||..||           ..|..:  |.::..:.|..|::.:::|...|....::...|:
  Rat   834 VKASCGFFTELL-----------PRCGEIESVGKVVQEDGRMLLIAVLEAIGGQASRSLMDCFAD 887

  Fly   864 VLHELKQVVGNERMQPFLAQAL-EALPKKNSGGYVTA--TQQQLDEFSSTVLRADTTK-AISQAL 924
            :|..|     |:.....|:..: |||   ...|:.:|  :.:|.|.||..:||....| .:.:.:
  Rat   888 ILFAL-----NKHCFSLLSMWIKEAL---QPPGFPSARLSPEQKDTFSQQILRERVNKRRVKEMV 944

  Fly   925 KTFTRLFR 932
            |.||.|.|
  Rat   945 KEFTLLCR 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnpo-SR	NP_001259961.1	IBN_N	28..94	CDD:281761	22/65 (34%)
		Xpo1	100..248	CDD:285575	42/158 (27%)
		HEAT repeat	427..454	CDD:293787	8/28 (29%)
		HEAT repeat	462..496	CDD:293787	8/33 (24%)
		HEAT repeat	506..531	CDD:293787	7/24 (29%)
Ipo13	NP_446230.2	HEAT 1	24..54		8/29 (28%)
		IBN_N	45..109	CDD:197981	21/63 (33%)
		HEAT 2	56..88		8/31 (26%)
		HEAT 3	95..135		13/40 (33%)
		Xpo1	117..263	CDD:400614	43/158 (27%)
		HEAT 4	142..179		10/36 (28%)
		HEAT 5	194..231		10/40 (25%)
		HEAT 6	236..268		9/37 (24%)
		HEAT 7	276..325		12/60 (20%)
		HEAT 8	330..372		9/41 (22%)
		HEAT 9	375..438		16/62 (26%)
		Importin_rep	402..441	CDD:408544	11/38 (29%)
		HEAT 10	440..476		8/35 (23%)
		HEAT 11	487..522		9/35 (26%)
		HEAT 12	524..558		10/34 (29%)
		HEAT 13	562..600		5/37 (14%)
		Importin_rep_2	584..627	CDD:408557	8/42 (19%)
		HEAT 14	603..648		7/44 (16%)
		Importin_rep_2	631..669	CDD:408557	5/37 (14%)
		HEAT 15	676..716		12/39 (31%)
		HEAT 16	720..754		7/33 (21%)
		HEAT 17	761..803		11/43 (26%)
		HEAT 18	815..845		7/29 (24%)
		Importin_rep_3	826..900	CDD:408577	14/89 (16%)
		HEAT 19	860..893		7/37 (19%)
		HEAT 20	897..931		10/36 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910