Protein Alignment Tnpo-SR and Ipo13

DIOPT Version :10

• Sequence 1: NP_608708.2
• Gene: Tnpo-SR / 33465
• FlyBaseID: FBgn0031456
• Length: 932
• Species: Drosophila melanogaster
• Sequence 2: NP_446230.2
• Gene: Ipo13 / 116458
• RGDID: 620071
• Length: 963
• Species: Rattus norvegicus
• Alignment Length: 983
• Identity: 231/983 - (23%)
• Similarity: 431/983 - (43%)
• Gaps: 105/983 - (10%)

  Fly     4 YSVDVVYQAISALFQGNNPKEQEKANKWLQDFQKSIYSWTIADELLHQKRDLHANYFAAQTMRNK 68
            ::|:.|.:|:..|:...|.:.:..|.|||...|.|..:|..:.:||...:.....||.|..:..|
  Rat    21 FTVENVEKALHQLYYDPNIENKNLAQKWLMQAQVSPQAWHFSWQLLQPDKVPEIQYFGASALHIK 85

  Fly    69 IQNSFSELPPHTHESLRDSLITHIGQIDEQTDNVIVTQLSLAVADLALLMA--SWREPINDLLVT 131
            |...:|::|...:|||:..|.|.|.:. .....:::|:|.:|:|.|||.|.  :|...:.|::..
  Rat    86 ISRYWSDIPTDQYESLKAQLFTQITRF-ASGSKIVLTRLCVALASLALSMMPDAWPCAVADMVRL 149

  Fly   132 LAPHQCAI------WPLLEVLKVLPEEIDSRYLRLGANRREEVHKQLDASAECVLKFLCMCLQRE 190
            .......:      ..|||:|.|||||..:.  ||...|:..|...|......|...|...||:.
  Rat   150 FQAEDSPVDSQGRCLALLELLTVLPEEFQTS--RLPQYRKGLVRASLAVECGAVFPLLEQLLQQP 212

  Fly   191 DLD---QQRVWNAALRTYSAWLVIHAFPVSHVYNNALTQLAFRLLSLPETSGKLHDNATECVCAL 252
            ...   :|:|    |:.:|:|:.:.. |:...  .||.|.||..|.    ..:|.|::.|.:...
  Rat   213 SSPSCVRQKV----LKCFSSWVQLEV-PLQDC--EALIQAAFAALQ----DSELFDSSVEAIVNA 266

  Fly   253 LS------CINTRQDGASDPESSFEAQLFGAVCMLETPYHLSVAHEDTDKTINYCRIFTSLCDAF 311
            :|      .:||.            .:|...|..|:.....:|.:.|.:.:...|||..:|.:..
  Rat   267 ISQPDAQRYVNTL------------LKLIPLVLGLQEQLRQAVQNGDMETSHGICRIAVALGENH 319

  Fly   312 FYDLLADAQKPHYSLKGLDLVLLCV---GHF--DYEVAEITFHLWYKLSEDLFQRNEDKLTV--- 368
            ...||...:.....|..:::::.|.   ||:  :...:.:|...||.|.:|:.....:|..|
  Rat   320 SRALLDQVEHWQSFLALVNMIMFCTGIPGHYPVNETTSSLTLTFWYTLQDDILSFEAEKQAVYQQ 384

  Fly   369 LFRPHIERLISALFRHSQMESDHD-GL--IEENNNFFDFRRKVSDLIKDVAFIVGS---GACFKQ 427
            ::||...:|:..|...:|..||.: |.  .:|...|..:|..:||.:..|..::|:   ...:.:
  Rat   385 VYRPVYFQLVDVLLHKAQFPSDEEYGFWSSDEKEQFRIYRVDISDTLMYVYEMLGAELLSNLYDK 449

  Fly   428 MFHILQAPET--TWESTEAALFIMQNVAKNILPDENEVIPKVVEAILNMSEQTHIAVRYTAILLI 490
            :..:|.:.|.  :|:.|||.|:..|::|:.|..:.::|:|.::..|..:| .:::.:..|.:..|
  Rat   450 LGRLLTSSEEPYSWQHTEALLYGFQSIAETIDVNYSDVVPGLIGLIPRIS-ISNVQLADTVMFTI 513

  Fly   491 GELCDWIENHPESLEAVLNFLLYALQQKNGLAPAAAIALTSICSACRQKMVCHISGLVEIARSLD 555
            |.|.:|:.:||..:.:||..:|:||.... |:.::...|..||..|:..:..:.:.:|.:::.:.
  Rat   514 GALSEWLADHPVMINSVLPLVLHALGNPE-LSVSSVSTLKKICRECKYDLPPYAANIVAVSQDVL 577

  Fly   556 SFQIN-NDVAIGLLKGISLILTRLPREQLQPALREIVGFQLQPLAQLVDSTGSTPQK-------G 612
            ..||: ....:.|::.:..:|:.|..|::...|..::...:|.|.:|.:...:...|       |
  Rat   578 MKQIHKTSQCMWLMQALGFLLSALQVEEILKNLHSLISPYIQQLEKLAEEIPNPSNKLAIVHILG 642

  Fly   613 ERTDPVYWIDRACAIIRHTNPD-----VPDNVEHPTVAILNDAWQLISRVMDKYQSDLRIMERTC 672
            ..::....:|.:.....|..|:     ||.. .:|.|.:|...:|||.:|:.|:.||.:::|..|
  Rat   643 LLSNLFTTLDVSHHEDDHEGPELRKLPVPQG-PNPVVVVLQQVFQLIQKVLSKWLSDAQVVEAVC 706

  Fly   673 RLIRYGIRMVRKQAMMLVEPLIKQMVVLYSVQHHSCFLYVGSILVDEFAKSSECIGGLLEMLQAF 737
            .:....::.:......:|..|.:.:..:||....:..|.:...||..||........:..:....
  Rat   707 AIFEKSVKTLLDDFAPMVPQLCEMLGRMYSTVPQASALDLTRQLVHIFAHEPAHFPPIEALFLLV 771

  Fly   738 IEPTFGLLQMENGLKNNPDTVDDFFRLASRYLDCCPHQLLQSSL--ITPIFQCALIACSLDHREA 800
            ...|..|.|  .|.:::||.||.|.:|.::.|...| .|.|...  :..:||||::|........
  Rat   772 TSVTLSLFQ--QGPRDHPDIVDSFMQLLAQALKRKP-DLFQCERLDVKAVFQCAVLALKFPEAPT 833

  Fly   801 NSSVMKFFINLLVWGRSNNHSRNTECRPL--VVELASQHGGALVMNLIQASVFQLHSYMLVDVAE 863
            ..:...||..||           ..|..:  |.::..:.|..|::.:::|...|....::...|:
  Rat   834 VKASCGFFTELL-----------PRCGEIESVGKVVQEDGRMLLIAVLEAIGGQASRSLMDCFAD 887

  Fly   864 VLHELKQVVGNERMQPFLAQAL-EALPKKNSGGYVTA--TQQQLDEFSSTVLRADTTK-AISQAL 924
            :|..|     |:.....|:..: |||   ...|:.:|  :.:|.|.||..:||....| .:.:.:
  Rat   888 ILFAL-----NKHCFSLLSMWIKEAL---QPPGFPSARLSPEQKDTFSQQILRERVNKRRVKEMV 944

  Fly   925 KTFTRLFR 932
            |.||.|.|
  Rat   945 KEFTLLCR 952

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tnpo-SR	NP_608708.2	IBN_N	28..94	CDD:197981	22/65 (34%)
		Xpo1	100..249	CDD:462459	43/159 (27%)
		HEAT repeat	427..454	CDD:293787	8/28 (29%)
		HEAT repeat	462..496	CDD:293787	8/33 (24%)
		HEAT repeat	506..531	CDD:293787	7/24 (29%)
Ipo13	NP_446230.2	HEAT 1	24..54		8/29 (28%)
		IBN_N	45..109	CDD:197981	21/63 (33%)
		HEAT 2	56..88		8/31 (26%)
		HEAT 3	95..135		13/40 (33%)
		Xpo1	116..263	CDD:462459	43/159 (27%)
		HEAT 4	142..179		10/36 (28%)
		HEAT 5	194..231		10/40 (25%)
		HEAT 6	236..268		9/37 (24%)
		HEAT 7	276..325		12/60 (20%)
		HEAT 8	330..372		9/41 (22%)
		HEAT 9	375..438		16/62 (26%)
		Importin_rep	402..441	CDD:436727	11/38 (29%)
		HEAT 10	440..476		8/35 (23%)
		HEAT 11	487..522		9/35 (26%)
		HEAT 12	524..558		10/34 (29%)
		HEAT 13	562..600		5/37 (14%)
		Importin_rep_2	584..627	CDD:408557	8/42 (19%)
		HEAT 14	603..648		7/44 (16%)
		Importin_rep_2	631..669	CDD:408557	5/37 (14%)
		HEAT 15	676..716		12/39 (31%)
		HEAT 16	720..754		7/33 (21%)
		HEAT 17	761..803		11/43 (26%)
		HEAT 18	815..845		7/29 (24%)
		Importin_rep_3	826..900	CDD:465873	14/89 (16%)
		HEAT 19	860..893		7/37 (19%)
		HEAT 20	897..931		10/36 (28%)