DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tnpo-SR and tnpo3

DIOPT Version :9

Sequence 1:	NP_001259961.1	Gene:	Tnpo-SR / 33465	FlyBaseID:	FBgn0031456	Length:	932	Species:	Drosophila melanogaster
Sequence 2:	XP_031754955.1	Gene:	tnpo3 / 100490799	XenbaseID:	XB-GENE-998615	Length:	933	Species:	Xenopus tropicalis

Alignment Length:	941	Identity:	400/941 - (42%)
Similarity:	587/941 - (62%)	Gaps:	28/941 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VDVVYQAISALFQGNNPKEQEKANKWLQDFQKSIYSWTIADELLHQKRDLHANYFAAQTMRNKIQ 70
            :..||||:.||:...:|..:|:|:.||.:.|:|:|:|.|||:||...:|:.:.|||||||:.|||
Frog     7 LQTVYQAVQALYHDPDPSGKERASLWLGELQRSVYAWEIADQLLQIHQDVESCYFAAQTMKVKIQ 71

  Fly    71 NSFSELPPHTHESLRDSLITHIGQIDEQTDNVIVTQLSLAVADLALLMASWREPINDLLVTLAPH 135
            .||.|||..:|.||||||::||..:.:.:. ||:|||:||:||||||||||:..:..|:.:.:..
Frog    72 TSFYELPSDSHVSLRDSLLSHIQNLKDMSP-VILTQLALAIADLALLMASWKGCVQTLVESYSND 135

  Fly   136 QCAIWPLLEVLKVLPEEIDSRYLRLGANRREEVHKQLDASAECVLKFLCMCLQREDLDQQRVWNA 200
            ..::..|||:|.|||||:.||.||:|||||.|:.:.|...:..|:..|..|.::.. |.:::...
Frog   136 VTSLPFLLEILTVLPEEVHSRSLRIGANRRAEIIEDLAYYSSTVVSLLLSCAEKAG-DNEKMLIK 199

  Fly   201 ALRTYSAWLVIHAFPVSHVYNNALTQLAFRLLSLPETSGKLHDNATECVCALLSCINTRQDGASD 265
            ..:...:|..:.....:.:.||.|..|.|::|....|...||:.|::|||:.|..|       .:
Frog   200 IFKCLGSWFNLGVLDSNFMANNRLLLLLFQVLQQDRTPTNLHEAASDCVCSALYAI-------EN 257

  Fly   266 PESS--FEAQLFGAVCMLETPYHLSVAHEDTDKTINYCRIFTSLCDAFFYDLLADAQKPHYSLKG 328
            .||:  ...|||..|..|||.||::||.||.||.:|||||||.||:.|...::....:....|:.
Frog   258 VESNLPLATQLFQGVLTLETAYHMAVAREDIDKVLNYCRIFTELCETFLEKIVTTPCRDLGDLRT 322

  Fly   329 LDLVLLCVGHFDYEVAEITFHLWYKLSEDLFQRNEDKLTVLFRPHIERLISALFRHSQMESDHDG 393
            |:|:|:|.||..|||.||:|:.||:|.|.|::..:..:..:|:|.|:||:.||.||.|:|.||:|
Frog   323 LELLLICAGHPQYEVVEISFNFWYRLGEHLYKMTDAVIHGIFKPFIQRLLHALARHCQLEPDHEG 387

  Fly   394 LIEENNNFFDFRRKVSDLIKDVAFIVGSGACFKQMFHILQAPETTWESTEAALFIMQNVAKNILP 458
            :.||.::|.:||.:||||:||:.::|||..||.|::..|:.....||.|||.||||..:||:|.|
Frog   388 VPEETDDFGEFRLRVSDLVKDLIYLVGSMECFSQLYSTLKDGNPPWEVTEAVLFIMAAIAKSIDP 452

  Fly   459 DENEVIPKVVEAILNMSEQTHIAVRYTAILLIGELCDWIENHPESLEAVLNFLLYALQQKNGLAP 523
            :.|..:.:|:|.::.:.|..|||||||:|.|:||:.:.::.:|:.|:.||.:|:..|.|.: ||.
Frog   453 ENNPTLVEVLEGVVRLPESVHIAVRYTSIELVGEMSEVVDRNPQFLDPVLAYLMKGLFQPS-LAS 516

  Fly   524 AAAIALTSICSACRQKMVCHISGLVEIARSLDSFQINNDVAIGLLKGISLILTRLPREQLQPALR 588
            .:|.|:.:|||.||..|..|.:||:|||||||||.::.|.|:|||||.:|:|.|||.|::...|.
Frog   517 PSAKAIQNICSVCRDHMALHFNGLLEIARSLDSFTLHPDAAVGLLKGTALVLARLPLEKISECLS 581

  Fly   589 EIVGFQLQPLAQLVDSTGSTPQKGERTDPVYWIDRACAI-----------IRHTNPDVPDNVEHP 642
            |:...|:..|.:|:   ...|..|..:||..::||...|           .|||||.|.:...||
Frog   582 ELCSVQVNSLKRLL---SQDPNNGLSSDPTLFLDRLAVIFRTFSQKDIGLFRHTNPIVENGQTHP 643

  Fly   643 TVAILNDAWQLISRVMDKYQSDLRIMERTCRLIRYGIRMVRKQAMMLVEPLIKQMVVLYSVQHHS 707
            ...::.:.|.::|..|:|:::|.||:||.||.:|:.:|.|.|.:..|::||:.|||.:|.:..||
Frog   644 CQKVIQEIWPVLSETMNKHRADNRIVERCCRCLRFAVRCVGKGSAALLQPLVTQMVEVYHIHQHS 708

  Fly   708 CFLYVGSILVDEFAKSSECIGGLLEMLQAFIEPTFGLLQMENGLKNNPDTVDDFFRLASRYLDCC 772
            ||||:|||||||:.....|..|||:||||...|||.||:.:|||:|:||||||.|||.:|::..|
Frog   709 CFLYLGSILVDEYGMEEGCQQGLLDMLQALCVPTFQLLEQQNGLRNHPDTVDDLFRLFTRFVQRC 773

  Fly   773 PHQLLQSSLITPIFQCALIACSLDHREANSSVMKFFINLLVWGRSNNHSRNTECR-PLVVELASQ 836
            |..||:|.::..:.:.|:.|.:||||:||.|||||..:|:..|.||:|..|.|.| .|:.::.:|
Frog   774 PIVLLRSQVVIHVLRWAIAASTLDHRDANCSVMKFLRDLIHTGVSNDHEENFEIRKDLIQQVLTQ 838

  Fly   837 HGGALVMNLIQASVFQLHSYMLVDVAEVLHELKQVVGNERMQPFLAQALEALPKKNSGGYVTATQ 901
            .|..||..||.|..|.|..|.|.||||||.| ..|........:|..:|:.|||..:.|..|.|.
Frog   839 VGQQLVSQLIHACCFCLPPYTLPDVAEVLWE-AMVFNRPTFCRWLEASLKNLPKDMAVGAATVTH 902

  Fly   902 QQLDEFSSTVLRADTTKAISQALKTFTRLFR 932
            :||.:|...|..|:..|.:..||:.||||||
Frog   903 KQLTDFHKQVTSAEECKQVCWALRDFTRLFR 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnpo-SR	NP_001259961.1	IBN_N	28..94	CDD:281761	37/65 (57%)
		Xpo1	100..248	CDD:285575	53/147 (36%)
		HEAT repeat	427..454	CDD:293787	11/26 (42%)
		HEAT repeat	462..496	CDD:293787	14/33 (42%)
		HEAT repeat	506..531	CDD:293787	9/24 (38%)
tnpo3	XP_031754955.1	IBN_N	29..95	CDD:197981	37/65 (57%)
tnpo3	XP_031754955.1	Xpo1	120..221	CDD:400614	28/101 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	559	1.000	Domainoid score	I238
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H40848
Inparanoid	1	1.050	740	1.000	Inparanoid score	I592
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D179626at33208
OrthoFinder	1	1.000	-	-		FOG0004702
OrthoInspector	1	1.000	-	-		oto102612
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5042
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.060