Protein Alignment form3 and BNI1

DIOPT Version :10

• Sequence 1: NP_001097527.1
• Gene: form3 / 3346238
• FlyBaseID: FBgn0053556
• Length: 1717
• Species: Drosophila melanogaster
• Sequence 2: NP_014128.2
• Gene: BNI1 / 855450
• SGDID: S000005215
• Length: 1953
• Species: Saccharomyces cerevisiae
• Alignment Length: 1178
• Identity: 260/1178 - (22%)
• Similarity: 431/1178 - (36%)
• Gaps: 305/1178 - (25%)

  Fly    25 DTQNATVKKQVFELLSALCAYSPDGYARAIETLEFYKNLKKQRYRFKIVINELELSSAAAHPPLD 89
            |.....|:::|.||.:       :..:.|::.|   |.|:.:...|.|..|..|:..:......|
Yeast   946 DISKFNVEERVNELFN-------EKKSLALKRL---KELETKYKGFGIDFNVDEIMDSPKKNTGD 1000

  Fly    90 YQAALLAFINCVIISAATLQERI----RIRNEFIGLKVLPLLNNLRLLEAGNVESSAS------- 143
            .:....|  |...:...|.|:::    ||.::.:.::. ...:.:::.|.|..:.|:|
Yeast  1001 VETEEDA--NYASLDPKTYQKKLDEINRITDQLLDIQT-QTEHEIQVEEDGESDLSSSSSDDESE 1062

  Fly   144 -----PSPPPSLSSESA--SSATSP----------------VSGSASTSVTPSPS---PLHLQRR 182
                 .||...|.||.:  ||.:.|                |:.||:.....:.|   |||.:..
Yeast  1063 EIYQDASPTQELRSEHSELSSGSGPGSFLDALSQKYGTGQNVTASAAFGENNNGSGIGPLHSKVE 1127

  Fly   183 LTFCGSLSRYSCAAL----QLVQNLKKVAQSVGDIIVQLDVFVEQQECDEAQSLQAPDGINLNSH 243
            .||...|.:.:.::.    :|.|.:.||..            .||.|.:.......|:    ||.
Yeast  1128 KTFMNRLRKSTVSSAPYLEELTQKVNKVEP------------YEQNEDEGLDKKSLPE----NST 1176

  Fly   244 LDVFYAILRQVADTPQEVPFLNILQHLLRIDPKEPLSDIIWDTTERLVHRATLLESHEDSVRLLR 308
            .....|..:...|..|.|.  |..|..:....::..:|  :....:|        ::.|....|.
Yeast  1177 ASAASAFDKAEKDMRQHVE--NGKQGRVVNHEEDKTAD--FSAVSKL--------NNTDGAEDLS 1229

  Fly   309 TPSSQKFACQSCRGSDASSPTRKPSQPVGVSAKTTPPPPPPPMAPA------------------- 354
            |.||.                        :|::..|||||||..||
Yeast  1230 TQSSV------------------------LSSQPPPPPPPPPPVPAKLFGESLEKEKKSEDDTVK 1270

  Fly   355 ------APPPPPPPINGAAPPPPPPPM-ING---GALPPPPPPPSMQMASR----PRTPDPLAAE 405
                  :|.|||||     |||||||| :.|   |..|||||.||:..:|.    |..|..:.|.
Yeast  1271 QETTGDSPAPPPPP-----PPPPPPPMALFGKPKGETPPPPPLPSVLSSSTDGVIPPAPPMMPAS 1330

  Fly   406 AVATAI---LLPQQDT-----PAPKAKMKTINWGKI--PHNKVLGKQNIWSIVASNHQDSPMQDI 460
            .:.:|:   ||||..:     |.|..|:|.::|.|:  ..|.:.|...........::...:.|:
Yeast  1331 QIKSAVTSPLLPQSPSLFEKYPRPHKKLKQLHWEKLDCTDNSIWGTGKAEKFADDLYEKGVLADL 1395

  Fly   461 D----WNEMEGLFCLQTASAQGSPKLGRDGSQAAAGSNGCDTLDRKSKKESTEITLLDGKRSLNV 521
            :    ..|::.|...:....|....|.||.|| ..|.|    |...|.....::.    |:.||.
Yeast  1396 EKAFAAREIKSLASKRKEDLQKITFLSRDISQ-QFGIN----LHMYSSLSVADLV----KKILNC 1451

  Fly   522 N-IFLK-----QFRTSNDDI---IQLIRQGAHEEIGAERLRGLLKIM-PEVDELDMLKGFNGDKA 576
            : .||:     :|.:.::.|   :.|.|..|......|.:|.|.... ||.|..|
Yeast  1452 DRDFLQTPSVVEFLSKSEIIEVSVNLARNYAPYSTDWEGVRNLEDAKPPEKDPND---------- 1506

  Fly   577 RLGNAEKFLLQLL-EVPNY---KLRIESMLLK-----EEFAANVAYLEPCINSMLYAGDDLLNNK 632
             |..|::..|||: .:.:|   ::|..:::..     .|..|.:..::..: |.|...|:|.|
Yeast  1507 -LQRADQIYLQLMVNLESYWGSRMRALTVVTSYEREYNELLAKLRKVDKAV-SALQESDNLRN-- 1567

  Fly   633 TLQEVLYMVVVAGNFLNSGGYAGNAAGVKLSSLQKLTDIRANKPGMNLIHFVALQAEKRNPELLQ 697
                |..:::..|||:|.  .:..|.|.|||:||:||.|:.....|..:::|........|....
Yeast  1568 ----VFNVILAVGNFMND--TSKQAQGFKLSTLQRLTFIKDTTNSMTFLNYVEKIVRLNYPSFND 1626

  Fly   698 FTGQLSNLESASKTTSEQINNEINTLDGRIRRIARQIE----------QPATDVDIK-------- 744
            |..:|..:....|.:.||:.|:.......|..:.|.:|          .|...|.||
Yeast  1627 FLSELEPVLDVVKVSIEQLVNDCKDFSQSIVNVERSVEIGNLSDSSKFHPLDKVLIKTLPVLPEA 1691

  Fly   745 EQMADFLQAAESELSVLQAGMKQVESMRLKMSEFFCDDAATFRLEECFKIFHNFCDKFKQAVKEN 809
            .:..|.|: .|.:|:::     :.||:   |..:..|....|.....||.|.:|.:::|:|..:|
Yeast  1692 RKKGDLLE-DEVKLTIM-----EFESL---MHTYGEDSGDKFAKISFFKKFADFINEYKKAQAQN 1747

  Fly   810 ERRQQQEQQATLRRKQREEQLAR---RARQIGQAGTPVSDSEHSFLGDAIFDPRASPALSRRHLG 871
            ...:::|:.....:|..|||..|   :.:|...:.:|.|:..
Yeast  1748 LAAEEEERLYIKHKKIVEEQQKRAQEKEKQKENSNSPSSEGN----------------------- 1789

  Fly   872 SGEISNGFIRLEQDGASPDITPNGSLRRRRSRVLAEEDDLMEFLRSSTGPHHDGHNSRERKAAYG 936
                       |:|.|..          ||    |..|.|:|.|::: ||.....:|..::|..
Yeast  1790 -----------EEDEAED----------RR----AVMDKLLEQLKNA-GPAKSDPSSARKRALV- 1827

  Fly   937 SLDRSWARRARSGSSSRKRPDLLNIDFGMDRERAS---SPAPLLQQQQQNVQERLQSPLASTAGT 998
                    |.:..|.....|.|||   .:|.|..|   ||..:.......:.....:||| |.|.
Yeast  1828 --------RKKYLSEKDNAPQLLN---DLDTEEGSILYSPEAMDPTADTVIHAESPTPLA-TRGV 1880

  Fly   999 PTTAANTPTGSGSAIAQTPSNNEDAKPRISREWRQKIETWLQSNESDEKQNEEYRRKRRLV---- 1059
            ..|:.:.|:.|.::..:......|....:.:|.|.......|::..||...:...||.|.:
Yeast  1881 MNTSEDLPSPSKTSALEDQEEISDRARMLLKELRGSDTPVKQNSILDEHLEKLRARKERSIGEAS 1945

  Fly  1060 NANRRSLE 1067
            ..||.|.:
Yeast  1946 TGNRLSFK 1953

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
form3	NP_001097527.1	Drf_FH3	48..309	CDD:461885	57/301 (19%)
		FH2	415..803	CDD:396655	97/435 (22%)
		PTZ00449	<1145..1465	CDD:185628
BNI1	NP_014128.2	Drf_GBD	178..458	CDD:461886
		Drf_FH3	511..707	CDD:461885
		PTZ00491	<690..801	CDD:240439
		FH2	1348..1741	CDD:396655	96/430 (22%)
		PTZ00121	<1739..1841	CDD:173412	29/159 (18%)