Protein Alignment form3 and inf2

DIOPT Version :10

• Sequence 1: NP_001097527.1
• Gene: form3 / 3346238
• FlyBaseID: FBgn0053556
• Length: 1717
• Species: Drosophila melanogaster
• Sequence 2: NP_001072591.1
• Gene: inf2 / 780046
• XenbaseID: XB-GENE-5862185
• Length: 1380
• Species: Xenopus tropicalis
• Alignment Length: 1454
• Identity: 385/1454 - (26%)
• Similarity: 609/1454 - (41%)
• Gaps: 389/1454 - (26%)

  Fly     1 MDSRIGLDYIVENRDYIAKLGAALDTQNATVKKQVFELLSALCAYSPDGYARAIETLEFYKNLKK 65
            |:|..|::|||.|..|:.||..||||.|..|||||||||:|||.|||:|:|.:::.||.||.:|.
 Frog   109 MNSHRGIEYIVNNEGYVRKLSQALDTSNVMVKKQVFELLAALCIYSPEGHALSLDALEHYKAVKN 173

  Fly    66 QRYRFKIVINELELSSAAAHPPLDYQAALLAFINCVIISAATLQERIRIRNEFIGLKVLPLLNNL 130
            |:|||.:::|||..|.     .:.|...||:.||.:|.....|::|:::|||||||::|.||..|
 Frog   174 QQYRFSVIMNELSTSD-----NVPYMVTLLSAINAIIFGTEELRKRVQLRNEFIGLQLLDLLTKL 233

  Fly   131 RLLEAGNVESSASPSPPPSLSSESASSATSPVSGSASTSVTPSPSPLHLQRRLTFCGSLSRYSCA 195
            |.||.
 Frog   234 RDLED------------------------------------------------------------ 238

  Fly   196 ALQLVQNLKKVAQSVGDIIVQLDVFVEQQECDEAQSLQAPDGINLNSHLDVFYAILRQVADTPQE 260
                           .|:::|..||.|.:..||.:.|:...||::|:|.:||..:..:|:.:|..
 Frog   239 ---------------EDLLIQAIVFEEAKSEDEEELLKIYGGIDMNNHQEVFSTLFNKVSCSPLS 288

  Fly   261 VPFLNILQHLLRIDPKEPLSDIIWDTTERLVHRATLL---------------------------- 297
            |..|::||.||.:|...|.|.::|:..:.||:||.||
 Frog   289 VQLLSVLQGLLHLDQSHPSSPLLWEALDILVNRAVLLADDCQNNNVEEVMDRLVTSKKHPSKEKR 353

  Fly   298 --------------------ESHEDSVRLLRTPSSQKFACQSCRGSDA----------------- 325
                                ||.|:.. :.:.|.|......|.:.|||
 Frog   354 KPDKCTNQVNKSIQTDKPKDESCEEKT-VKKDPVSSGIPADSLQLSDALLALPACVSPLHTPLSG 417

  Fly   326 --SSPTRKPSQPVGVSAK------------------------TTPPPPPPP--------MAPAAP 356
              :||:..||.|..|.:.                        :.|||||||        :.|..|
 Frog   418 DITSPSHFPSPPSPVVSNAIDRISTSSSLPPPLPPPLPGTELSLPPPPPPPLPGMGGISLTPPPP 482

  Fly   357 ----------PPPPPPI---NGAAPPPPPPPMINGGALP-------------PPPPPPSMQMASR 395
                      ||||||:   .|..||||||....||.||             ||||||...|...
 Frog   483 PPLPGMGGMLPPPPPPLPGMGGMLPPPPPPLPGMGGMLPPPPPPLPGMGGMLPPPPPPLPGMGGM 547

  Fly   396 PRTPDPLAA-------------------EAVATAI-----LLPQQ--DTPAPKAKMKTINWGKIP 434
            |..|.||..                   |.|...:     .||:.  ....|..|||.:||.|:|
 Frog   548 PPPPPPLPGMGGMPPPPPPMFGMGTFTDEVVVARVDYSLGYLPKAYFKVNKPTLKMKKLNWQKLP 612

  Fly   435 HNKVLGKQNIWSIVASNHQDSPMQDIDWNEMEGLFCLQTASAQGSPKLGRDGSQAAAGSNGCDTL 499
            .|.:....::|: .||:..|:|  :.:::.:|.||||..|.|:          :.||
 Frog   613 PNVINDTHSMWA-SASSSNDTP--EPNYSSIEQLFCLPQAVAK----------EPAA-------- 656

  Fly   500 DRKSKKESTEITLLDGKRSLNVNIFLKQFRTSNDDIIQLIRQGAHEEIGAERLRGLLKIMPEVDE 564
              ..||...||:.||.|::||:|||||||:..|:::||||.:|.......|.|:..||::||..|
 Frog   657 --PVKKPPKEISFLDSKKNLNLNIFLKQFKCPNEEVIQLIEKGDRSRFDIEILKQFLKLLPEKHE 719

  Fly   565 LDMLKGFNGDKARLGNAEKFLLQLLEVPNYKLRIESMLLKEEFAANVAYLEPCINSMLYAGDDLL 629
            ::.||.:..|||:|.||::|.|.||.:|.|:||||.||:.||.......|.|....:..|.||::
 Frog   720 VENLKSYQEDKAKLSNADQFYLLLLGIPCYQLRIECMLICEEVNLMTDVLRPKAKVVSSACDDII 784

  Fly   630 NNKTLQEVLYMVVVAGNFLNSGGYAGNAAGVKLSSLQKLTDIRANKPGMNLIHFVALQAEKRNPE 694
            ::..|.....:::..|||||.|.:.|||.|.|:.:|.|||:.:||:..:.|:|.:..:.|:.:.:
 Frog   785 SSHRLPLFCQLILKVGNFLNYGSHTGNANGFKIGTLLKLTETKANQNRITLLHHILEEIEQNHTD 849

  Fly   695 LLQFTGQLSNLESASKTTSEQINNEINTLDGRIRRIARQIEQPATDVDIKEQMADFLQAAESELS 759
            |||....|.|:.:|:....|.:.:|.:....::|.:..:|...||||  |:|....:|.....|.
 Frog   850 LLQLPSDLENVSTAAGINIENMYSETSGNLKKLRDLQNKISTAATDV--KDQYEKSIQECMDALK 912

  Fly   760 VLQAGMKQVESMRLKMSEFFCDDAATFRLEECFKIFHNFCDKFKQAVKENERRQQQEQQATLRRK 824
            .::..:..:...::|::::.|:|:|...|||.|.....|.|.|.:|.|:|:.|::|..:|..|:|
 Frog   913 EVEEQLTDITQKKVKLADYLCEDSAKLSLEETFSTMKAFRDLFLKAKKDNKDRKEQAVKAEKRKK 977

  Fly   825 QREEQLARRARQIGQAGTPVSDSEHSFLGDAIFDPRASPALSRRHLGSGEISNGFIRLEQDGASP 889
            |..::.|:  ||.|:.|..:                        ..|:.::..|.|   .|....
 Frog   978 QLADEEAK--RQKGENGKII------------------------RKGAAKLEEGCI---IDALLA 1013

  Fly   890 DITPNGSLRRRRSRVLAEEDDLMEFLRS-STGP--------HHDGHNSRERKAAYGSLDRSWARR 945
            || ..|...|:.::...|.|...:.:.| :||.        .|.|...:.:..:..:||.:...:
 Frog  1014 DI-KKGFQLRKTAKTKTEADSCPKPVSSETTGTDGTDVKHVDHVGILPQIKLDSSLNLDGTEQHK 1077

  Fly   946 ARS----GSSSRKRPDL---LNID-----FGMDRERASSPAPLLQQQQQNVQERLQSPLASTAGT 998
            ::|    |.:...:|.:   :|:|     ..:..:.|..|...| |:..|:::...:.:...:..
 Frog  1078 SKSKDNCGENFDNKPVVIAPINLDTSACLMNISEQNAKLPVSAL-QEGANLKQNPDTFVKEQSAI 1141

  Fly   999 PTTAANTPTG-SGSAIAQTPSNNEDAKPRISREWRQKIETWLQSNESDEKQNEEYRRKRRLVNAN 1062
            .||.::|... .||::.:......        :|..:|     |:|.|.|    |......|...
 Frog  1142 VTTESSTHNNIDGSSVDKCTLGQS--------QWPSEI-----SDEVDSK----YHEMPMQVEHK 1189

  Fly  1063 RRSLENETENERKLDPLPEEKILPSTTTATPTNTPTTTNPTNSTNRMDQESGKYQRVYADWKPSR 1127
            .|::|.:..       ||:..:|         .|.:::|..|:.|...|:       :.:...:.
 Frog  1190 ERAVEGKCS-------LPKPSVL---------GTESSSNQNNALNEGSQQ-------HHNNTANE 1231

  Fly  1128 TLEQTDVVANLQAIADAQPHDALR-----QHRRQRSQEQPSPIA-----------LQSIAEEDRR 1176
            :|:|....|..:|...:..|..::     |.....:..|||..:           |..:|.:.|.
 Frog  1232 SLQQAQNSALSEASQQSCCHTGIKGSPQFQSSALNADSQPSHTSVVGSAQAQRNELDDVALQTRD 1296

  Fly  1177 KSLIQ-KQGERDKSNERLQIYIRRSSSRELQPA-KT-EEHPLPPKSPK---PQVSDD--TFASLL 1233
            .::.: .|.|.||.|:            |..|. || .||||...|..   .|.|:|  ......
 Frog  1297 TTVTEGSQVEEDKCND------------EGYPEHKTMGEHPLNSSSHSTTLQQSSEDGQKVKRGS 1349

  Fly  1234 SHHKTQNEMQGSSKDVDADNIETP 1257
            |.||.:..   |||..:.|.:::|
 Frog  1350 SKHKKKRR---SSKHGEEDGVDSP 1370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
form3	NP_001097527.1	Drf_FH3	48..309	CDD:461885	72/308 (23%)
		FH2	415..803	CDD:396655	128/389 (33%)
		PTZ00449	<1145..1465	CDD:185628	33/137 (24%)
inf2	NP_001072591.1	Drf_GBD	<16..152	CDD:461886	26/42 (62%)
		Drf_FH3	156..332	CDD:461885	69/255 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	341..391		5/50 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	440..541		31/100 (31%)
		FH2	595..955	CDD:418645	128/384 (33%)
		WH2	1001..1028	CDD:425359	7/30 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1026..1049		5/22 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1188..1244		13/78 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1260..1380		32/126 (25%)