Protein Alignment form3 and Daam2

DIOPT Version :10

• Sequence 1: NP_001097527.1
• Gene: form3 / 3346238
• FlyBaseID: FBgn0053556
• Length: 1717
• Species: Drosophila melanogaster
• Sequence 2: NP_001008232.2
• Gene: Daam2 / 76441
• MGIID: 1923691
• Length: 1115
• Species: Mus musculus
• Alignment Length: 1015
• Identity: 238/1015 - (23%)
• Similarity: 445/1015 - (43%)
• Gaps: 203/1015 - (20%)

  Fly     1 MDSRIGLDYIVENRDYIAKLGAALDTQNATVKKQVFELLSALCAYSPDGYARAIETLEFYKNLKK 65
            |::..|..:::...:.|:.:..:|.|:|:..|..|.|:|.|:|.. |.|:.:.::.:..|:....
Mouse   185 MNNSQGRAHVLAQPEAISIIAQSLRTENSKTKVAVLEILGAVCLV-PGGHKKVLQAMLHYQAYAA 248

  Fly    66 QRYRFKIVINELELSSAAAHPPLDYQAALLAFINCVIISAA---TLQERIRIRNEFIGLKVLPLL 127
            :|.||:.::|||:.|.......::.:.|:::|||.|:.:.|   .|:.|:.:|.||:.|.:.|::
Mouse   249 ERTRFQTLLNELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHLRYEFLMLGIQPVI 313

  Fly   128 NNLRLLEAGNVESSASPSPPPSLSSESASSATSPVSGSASTSVTPSPSPLHLQRRLTFCGSLSRY 192
            :.||..|...::....                       ...:..:...|.|.||.......::.
Mouse   314 DKLRQHENAILDKHLD-----------------------FFEMVRNEDDLELARRFDMVHIDTKS 355

  Fly   193 SCAALQLVQNLKKVAQSVGDIIVQLDVFVEQQECDEAQSLQAPDGIN--LNSHLDVFYAILRQVA 255
            :....:|:....|..::...::..|      ..|     ||.|...|  ......:...||:|:
Mouse   356 ASQMFELIHKKLKHTEAYPCLLSVL------HHC-----LQMPYKRNGGYFQQWQLLDRILQQI- 408

  Fly   256 DTPQEVPFLNILQHLLRIDPK-EPL-----SDII-----------W-DTTERL----VHRATLLE 298
                      :||....:||. .||     .:|:           | |..|:.    :...:.||
Mouse   409 ----------VLQDERGVDPDLAPLENFNVKNIVNMLINENEVKQWRDQAEKFRKEHMELMSRLE 463

  Fly   299 SHE--------DSVRLLRT--PSSQKFACQS-----CRG----------SDASSPTRKPSQPVG- 337
            ..|        :...::||  ....|.|.:|     .||          ..::.|...|..|.|
Mouse   464 RKERECETKTLEKEEMMRTLNKMKDKLARESQELRQARGQVAELVARHNESSTGPVSSPPPPGGP 528

  Fly   338 ---VSAKTT---PPPPPPPMAPAAPPPPPPPINGAAPPPPP--PPMINGGALPPPPPPPSMQMAS 394
               .|::||   ||||||....:.||||.||:....||.||  ||..:.|      ||||....|
Mouse   529 LTLSSSRTTNDLPPPPPPLPFDSCPPPPAPPLPPGGPPIPPGAPPCFSSG------PPPSHDPFS 587

  Fly   395 RPRTPDPLAAEAVATAILLPQQDTPAPKAKMKTINWGKIPHNKVLGKQNIWSIVASNHQDSPM-Q 458
            ....|             |.::..|.|...:|:.||.|:...:|.|  .:|:.:    .||.: :
Mouse   588 SNEAP-------------LRKKRIPQPSHPLKSFNWVKLNEERVSG--TVWNEI----DDSQVFR 633

  Fly   459 DIDWNEMEGLF--------CLQTASAQGSPKLGRDGSQAA-------AGSNGCDTLDRK------ 502
            .:|..:.|.:|        |:|....:....: |||..|:       |.::..:...|.
Mouse   634 ILDLEDFEKMFSAYQRHQACMQEGPQRERGNV-RDGGAASRPLPAVEASAHRTEKASRSMVSATG 697

  Fly   503 SKKE--ST-----------EITLLDGKRSLNVNIFLKQFRTSNDDIIQ-LIRQGAHEEIGAERLR 553
            :|||  ||           |::::||:|:.|..|.|.:.:.|||:|.| ::|....|::..:.|.
Mouse   698 AKKELGSTEDIYITSRKVKELSVIDGRRAQNCIILLSKLKLSNDEIRQAILRMDEQEDLAKDMLE 762

  Fly   554 GLLKIMPEVDELDMLKGFNGDKARLGNAEKFLLQLLEVPNYKLRIESMLLKEEFAANVAYLEPCI 618
            .|||.:||..::|:|:....:..|:..|::||.::..:.:|:.|::::..|::|...:|..:|.:
Mouse   763 QLLKFIPEKSDIDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKV 827

  Fly   619 NSMLYAGDDLLNNKTLQEVLYMVVVAGNFLNSGGYAGNAAGVKLSSLQKLTDIRAN-KPGMNLIH 682
            .::|.|..:|..::.|:::|.:|:..|||:|. |..|.|.|.:::||.|:.|.::: ...::|:|
Mouse   828 EAILLASRELTLSQRLKQMLEVVLAIGNFMNK-GQRGGAYGFRVASLNKIADTKSSIDRNISLLH 891

  Fly   683 FVALQAEKRNPELLQFTGQLSNLESASKTTSEQINNEINTLDGRIRRIARQIE---QPATDVDIK 744
            ::.:..||..|::|....:|.:|..|:|....::..|::.|...:|.:..::|   ..|.|.:.|
Mouse   892 YLIMILEKHFPDILNMPSELKHLSEAAKVNLAELEKEVSILRRGLRAVEVELEYQRHQARDPNDK 956

  Fly   745 --EQMADFLQAAESELSVLQAGMKQVESMRLKMSEFFCDDAATFRLEECFKIFHNFCDKFKQAVK 807
              ..|:||:..:....|.|:..:.:......|....|.:..:..:.:|.|.||..|...|.:|.:
Mouse   957 FVPVMSDFITVSSFSFSELEDQLNEARDKFAKALTHFGEQESKMQPDEFFGIFDTFLQAFLEARQ 1021

  Fly   808 ENE----RRQQQEQQATLR---RKQREEQLARRARQIGQAGTPVSDSEHSFLGDAIFDPRASPAL 865
            :.|    |:::.|::|.:.   ::|||::..:|.|:: .||..:.:|     |:  ||...|.
Mouse  1022 DLEAMRRRKEEDERRARMEFMLKEQREKERWQRQRKV-LAGGALEES-----GE--FDDLVSA-- 1076

  Fly   866 SRRHLGSGEISNGFI------RLEQDGASPDITPNGSLRR 899
                |.|||:.:..:      |.......|::|...::.|
Mouse  1077 ----LRSGEVFDKDLSKFKRNRKRPGSQVPEVTRERAINR 1112

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
form3	NP_001097527.1	Drf_FH3	48..309	CDD:461885	53/295 (18%)
		FH2	415..803	CDD:396655	106/429 (25%)
		PTZ00449	<1145..1465	CDD:185628
Daam2	NP_001008232.2	Drf_GBD	41..228	CDD:461886	11/42 (26%)
		Drf_FH3	231..435	CDD:461885	47/248 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	510..605		35/113 (31%)
		FH2	595..1016	CDD:396655	106/428 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	655..697		7/42 (17%)