Protein Alignment form3 and FMNL1

DIOPT Version :10

• Sequence 1: NP_001097527.1
• Gene: form3 / 3346238
• FlyBaseID: FBgn0053556
• Length: 1717
• Species: Drosophila melanogaster
• Sequence 2: NP_001398057.1
• Gene: FMNL1 / 752
• HGNCID: 1212
• Length: 1104
• Species: Homo sapiens
• Alignment Length: 995
• Identity: 209/995 - (21%)
• Similarity: 384/995 - (38%)
• Gaps: 237/995 - (23%)

  Fly     1 MDSRIGLDYIVENRDYIAKLGAALDTQNATVKKQVFELLSALCAYSPDGYARAIETLEFYKNLKK 65
            |:.:.|...::.:...:.::..:|:.:|...|..|.|||:|:|... .|:...:...:.:|.:..
Human   238 MNYQSGFSLVMNHPACVNEIALSLNNKNPRTKALVLELLAAVCLVR-GGHDIILAAFDNFKEVCG 301

  Fly    66 QRYRFKIVINELELSSAAAHPPLDYQAALLAFINCVIISAATLQERIRIRNEFIGLKVLPLLNNL 130
            :::||:.::.......:    .:|:..|.:.|||.|:.|...:..|:.::.||..|.:...|..|
Human   302 EQHRFEKLMEYFRNEDS----NIDFMVACMQFINIVVHSVENMNFRVFLQYEFTHLGLDLYLERL 362

  Fly   131 RLLEAGNVESSASPSPPPSLSSESASSATSPVSGSASTSVTPSPSPLHLQ----------RRLTF 185
            ||.|:..::          :..::.......|......:.|.:....|::          .||..
Human   363 RLTESDKLQ----------VQIQAYLDNIFDVGALLEDTETKNAVLEHMEELQEQVALLTERLRD 417

  Fly   186 CGSLSRYSCAALQLVQNLKKVAQSVGDIIVQLDVFVEQQECDEAQSLQAPDGINLNSHLDVFYAI 250
            ..:.|....|.|:     |:::|:..::....:.|.|....  ..|.:.|:
Human   418 AENESMAKIAELE-----KQLSQARKELETLRERFSESTAM--GPSRRPPE-------------- 461

  Fly   251 LRQVADTPQEVPFLNILQHLLRIDPKEPLSDIIWDTTERLVHRATLLE------SHEDSVRLLRT 309
                   |::.|            |..|.             |.:.||      ..:..:|:||.
Human   462 -------PEKAP------------PAAPT-------------RPSALELKVEELEEKGLIRILRG 494

  Fly   310 PSSQ------KFACQSCRGSDASS---PTRKPSQPVGVSAKTTP---PPPPPPM---------AP 353
            |...      ..|..:..|.||.:   ||..||..:..:|:..|   ||||||:         .|
Human   495 PGDAVSIEILPVAVATPSGGDAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPP 559

  Fly   354 AAP-----------PPPPPPING---AAPPPPPPPMINGGALPPPPPPPSMQMASRPRTPDPLAA 404
            :||           |||.||:.|   ..|||||||....|.:|||||||          |.|...
Human   560 SAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPP----------PPPPGG 614

  Fly   405 EAVATAILLPQQDT---PAPKAK--------MKTINWGKIPHNKVLGKQNIWSIVASNHQDSPMQ 458
            ...|    |.::|:   |..|||        |..:||..:..:::.|     ::....:.:..:|
Human   615 PPDA----LGRRDSELGPGVKAKKPIQTKFRMPLLNWVALKPSQITG-----TVFTELNDEKVLQ 670

  Fly   459 DIDWNEMEGLFCLQTASAQGSPKLGRDGSQAAAGSNGCDTLDRKSKKESTEITLLDGKRSLNVNI 523
            ::|.::.|..|  :|.|...|..|....|:||             :|..::.||::..|:.|:.|
Human   671 ELDMSDFEEQF--KTKSQGPSLDLSALKSKAA-------------QKAPSKATLIEANRAKNLAI 720

  Fly   524 FLKQFRTSNDDIIQLIRQGAHEEIGAERLRGLLKIMPEVDELDMLKGFNGDK---ARLGNAEKFL 585
            .|::.....:.|.|.|.....:.:|.:.|..|::.:|...|..::..|..::   ..|...::|:
Human   721 TLRKGNLGAERICQAIEAYDLQALGLDFLELLMRFLPTEYERSLITRFEREQRPMEELSEEDRFM 785

  Fly   586 LQLLEVPNYKLRIESMLLKEEFAANVAYLEPCINSMLYAGDDLLNNKTLQEVLYMVVVAGNFLNS 650
            |....:|....|:.::.....|......|.|.:|:::.|...:.::..|:::|.:|:..||::||
Human   786 LCFSRIPRLPERMTTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEIVLAFGNYMNS 850

  Fly   651 GGYAGNAAGVKLSSLQKLTDIRANKPGMNLIHFVALQAEKRNPELLQFTGQLSNLESASKTTSEQ 715
             ...|.|.|.:|.||..|.::::......|:|::.....::.|:|..|...|..|:.|...:.:.
Human   851 -SKRGAAYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLDKAGSVSLDS 914

  Fly   716 INNEINTLDGRIRRIARQIEQPATDVDIKEQMADFLQAAESELSVLQAGMKQVESMRLKMSEFFC 780
            :..::.:|...:....|:..:....:.:||    ||:|....:..|.|..|..:.....:.|:|.
Human   915 VLADVRSLQRGLELTQREFVRQDDCMVLKE----FLRANSPTMDKLLADSKTAQEAFESVVEYFG 975

  Fly   781 DDAATFRLEECFKIFHNFCDKFKQAVKENE------------------------------RRQQQ 815
            ::..|......|.:|..|...:|:|.:|.|                              ||.|.
Human   976 ENPKTTSPGLFFSLFSRFIKAYKKAEQEVEQWKKEAAAQEAGADTPGKGEPPAPKSPPKARRPQM 1040

  Fly   816 EQQATLRRKQREEQLARRARQIGQAGTPVSDSEHSFLGDAIFDPRASPALSRRHLGSGEISNGFI 880
            :..:.|:|:|::|.|...:.:.|.            :.|.|.|.|..|               :|
Human  1041 DLISELKRRQQKEPLIYESDRDGA------------IEDIITDLRNQP---------------YI 1078

  Fly   881 RLEQDGASPDITPNGSLRRR 900
            |.:        |...|.|||
Human  1079 RAD--------TGRRSARRR 1090

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
form3	NP_001097527.1	Drf_FH3	48..309	CDD:461885	43/276 (16%)
		FH2	415..803	CDD:396655	84/401 (21%)
		PTZ00449	<1145..1465	CDD:185628
FMNL1	NP_001398057.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31
		Drf_GBD	34..281	CDD:461886	10/42 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	167..200
		Drf_FH3	284..>433	CDD:461885	29/167 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	446..474		9/75 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	510..635		48/138 (35%)
		FH2	633..998	CDD:396655	80/389 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1008..1037		0/28 (0%)