Protein Alignment form3 and Fmnl2

DIOPT Version :10

• Sequence 1: NP_001097527.1
• Gene: form3 / 3346238
• FlyBaseID: FBgn0053556
• Length: 1717
• Species: Drosophila melanogaster
• Sequence 2: XP_006498393.1
• Gene: Fmnl2 / 71409
• MGIID: 1918659
• Length: 1098
• Species: Mus musculus
• Alignment Length: 996
• Identity: 223/996 - (22%)
• Similarity: 403/996 - (40%)
• Gaps: 210/996 - (21%)

  Fly     1 MDSRIGLDYIVENRDYIAKLGAALDTQNATVKKQVFELLSALCAYSPDGYARAIETLEFYKNLKK 65
            |:.:.|.:.::.:...:.::..:|:.:|...|..|.|||:|:|... .|:...:...:.:|.:..
Mouse   232 MNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVR-GGHEIILSAFDNFKEVCG 295

  Fly    66 QRYRFKIVINELELSSAAAHPPLDYQAALLAFINCVIISAATLQERIRIRNEFIGLKVLPLLNNL 130
            ::.||:.::.......    ..:|:..|.:.|||.|:.|...:..|:.::.||..|.:...|:.|
Mouse   296 EKQRFEKLMEHFRNED----NNIDFMVASMQFINIVVHSVEDMNFRVHLQYEFTKLGLDEYLDKL 356

  Fly   131 RLLEAGNVESSASPSPPPSLSSESASSATSPVSGSASTSVTPSPSPLHLQRRLTFCGSLSRYSCA 195
            :..|:..::          :..::.......|......:.|.:             .:|.|..
Mouse   357 KHTESDKLQ----------VQIQAYLDNVFDVGALLEDAETKN-------------AALERVE-- 396

  Fly   196 ALQLVQNLKKVAQSVGDI-------IVQLDVFVEQQECDEAQSLQAPDGINLNSHLDVFYAILRQ 253
              :|.:|:..:::.:.|.       ||:|          |.|.:|.      |..|||...|.:.
Mouse   397 --ELEENISHLSEKLQDTENEAMSKIVEL----------EKQLMQR------NKELDVVREIYKD 443

  Fly   254 VADTPQEVPFLNILQHLLRIDPKEPLSDIIWDTTERLVHRATLLES--HE--------------D 302
            .          |...|.||...||         .|..:.|.:.||.  ||              .
Mouse   444 A----------NTQVHTLRKMVKE---------KEEAIQRQSTLEKKIHELEKQGTIKIQKKGDG 489

  Fly   303 SVRLLRTPSS------QKFACQSCRGSDASSPTRKPSQPVGVSAKTTPPPPP------------- 348
            .:.:|...:|      .:.|..:..||...:.|..||         .|||||
Mouse   490 DIAILPVMASGTLSTGSELAVGNYVGSVPGATTSGPS---------VPPPPPLPPSSDTSEAAQN 545

  Fly   349 ----PPMAPAAPPPPPPPINGAAPPPPPPPMINGGA--------LPPPPPPPSMQMASRPRTPDP 401
                |||:|..|||||||     |||||||.:.|.|        |||||||      |.|..|..
Mouse   546 GTASPPMSPPPPPPPPPP-----PPPPPPPPLPGPAAETSPAPPLPPPPPP------SAPPLPGT 599

  Fly   402 LAAEAVATAILLPQQDTP------------APKAKMKTINWGKIPHNKVLGKQNIWSIVASNHQD 454
            .:...|..:.|   .|.|            ..|.:|...||..:..|::.|     ::......:
Mouse   600 SSPTVVFNSGL---ADGPIKLFSVKIKKPIKTKFRMPVFNWVALKPNQING-----TVFNEIDDE 656

  Fly   455 SPMQDIDWNEMEGLFCLQTASAQGSPKLGRDGSQAAAGSNGCDTLDRKSKKESTEITLLDGKRSL 519
            ..::|::.:|.|.:|   ...||| |.:....|:           .:.::|.|:::|||:..|:.
Mouse   657 RILEDLNVDEFEEIF---KTKAQG-PAIDLSSSK-----------QKITQKASSKVTLLEANRAK 706

  Fly   520 NVNIFLKQFRTSNDDIIQLIRQGAHEEIGAERLRGLLKIMPEVDELDMLKGFNGDKARLGN---A 581
            |:.|.|::...|.|:|.:.|.....:.:..:.:..|::.:|..:|:.:|:.:..::..|.|   .
Mouse   707 NLAITLRKAGKSADEICKAIHVFDLKTLPVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDE 771

  Fly   582 EKFLLQLLEVPNYKLRIESMLLKEEFAANVAYLEPCINSMLYAGDDLLNNKTLQEVLYMVVVAGN 646
            ::|::|..::.....::..|.....|..::..|.|.:::::.|...:.:::.|:::|.:::..||
Mouse   772 DRFMMQFSKIERLLQKMTIMAFIGNFTESIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGN 836

  Fly   647 FLNSGGYAGNAAGVKLSSLQKLTDIRANKPGMNLIHFVALQAEKRNPELLQFTGQLSNLESASKT 711
            ::|| ...|...|.||.||..|.|.::......|:|:::...:::..::..|..:|..:|.|:..
Mouse   837 YMNS-SKRGAVYGFKLQSLDLLLDTKSTDRKQTLLHYISNVVKEKYQQVTLFYNELHYVEKAAAV 900

  Fly   712 TSEQINNEINTLDGRIRRIARQIEQPATDVDIKEQMADFLQAAESELSVLQAGMKQVESMRLKMS 776
            :.|.:..::..|...:....|:.    |..|....:.:||...|.:|..||...|..:.....:.
Mouse   901 SLENVLLDVKELQRGMDLTKREY----TMHDHNTLLKEFLLHNEGKLKKLQEDAKIAQDAFDDVV 961

  Fly   777 EFFCDDAATFRLEECFKIFHNFCDKFKQAVKENERRQQQEQQATLRRKQREEQLARRARQIGQAG 841
            ::|.::..|......|.:|..|...:|||.:|||.|::|| ||.:.:...:|.|..:.    .|.
Mouse   962 KYFGENPKTTPPSVFFPVFVRFVKAYKQAEEENELRKKQE-QALMEKLLEQEALMEQQ----DAK 1021

  Fly   842 TPVSDSEHSFLGDAIFDPRASPALSRRHLGSGEISNGFIRLEQDGASPDITP---NGSLRR---- 899
            :|...|:.. ..:.|.:.|.......||:..|          :|||..||..   |...||
Mouse  1022 SPSHKSKRQ-QQELIAELRRRQVKDNRHVYEG----------KDGAIEDIITDLRNQPYRRADAV 1075

  Fly   900 RRSRVLAEEDDLMEFLRSSTG 920
            ||| |....||  :.|||..|
Mouse  1076 RRS-VRRRFDD--QNLRSVNG 1093

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
form3	NP_001097527.1	Drf_FH3	48..309	CDD:461885	49/283 (17%)
		FH2	415..803	CDD:396655	80/402 (20%)
		PTZ00449	<1145..1465	CDD:185628
Fmnl2	XP_006498393.1	Drf_GBD	23..275	CDD:461886	10/42 (24%)
		Drf_FH3	278..475	CDD:461885	47/262 (18%)
		FH2	622..973	CDD:396655	75/375 (20%)