Protein Alignment form3 and Fmnl1

DIOPT Version :10

• Sequence 1: NP_001097527.1
• Gene: form3 / 3346238
• FlyBaseID: FBgn0053556
• Length: 1717
• Species: Drosophila melanogaster
• Sequence 2: NP_001390541.1
• Gene: Fmnl1 / 57778
• MGIID: 1888994
• Length: 1113
• Species: Mus musculus
• Alignment Length: 998
• Identity: 207/998 - (20%)
• Similarity: 376/998 - (37%)
• Gaps: 252/998 - (25%)

  Fly     1 MDSRIGLDYIVENRDYIAKLGAALDTQNATVKKQVFELLSALCAYSPDGYARAIETLEFYKNLKK 65
            |:.:.|...::.:...:.::..:|:.::...|..|.|||:|:|... .|:...:...:.:|.:..
Mouse   256 MNYQSGFSLVMNHPACVNEIALSLNNKSPRTKALVLELLAAVCLVR-GGHDIILAAFDNFKEVCG 319

  Fly    66 QRYRFKIVINELELSSAAAHPP--LDYQAALLAFINCVIISAATLQERIRIRNEFIGLKVLPLLN 128
            :::||:      :|.....|..  :|:..|.:.|||.|:.|...:..|:.::.||..|.:...|.
Mouse   320 EQHRFE------KLMEYFRHEDSNIDFMVACMQFINIVVHSVENMNFRVFLQYEFTHLGLDLYLE 378

  Fly   129 NLRLLEAGNVESSASPSPPPSLSSESASSATSPVSGSASTSVTPSPSPLHLQRRL--TF-CGSLS 190
            .|||.|:..::                                     :.:|..|  .| .|:|
Mouse   379 RLRLTESDKLQ-------------------------------------VQIQAYLDNVFDVGTL- 405

  Fly   191 RYSCAALQLVQNLKKVAQSVGDIIVQLDVFVEQQECDEAQSLQAPDGINLNSHLDVFYAILRQVA 255
                  |:..:....|.:.:.::..|:....|:....|            |..:.....:.:|::
Mouse   406 ------LEETETKNAVLEHMEELQEQVATLTERLRDTE------------NDSMAKIAELEKQLS 452

  Fly   256 DTPQEVPFLNILQHLLRIDPKEPLSDIIWDTTERL----------VHRATLLE------SHEDSV 304
            ...:|:..|.     .|.....|:.     |:.|:          |.|.:.||      ..:..:
Mouse   453 QARKELETLR-----ERFSESTPMG-----TSRRIPEPEKVPVPTVVRPSALELKVEELEEKGLI 507

  Fly   305 RLLRTPSS------QKFACQSCRGSDASSP---TRKPSQPVGVSAKTTPPPPPPPMAPAAP---- 356
            |:||.|..      ...|..:..|.||.:|   |..||....:....:|||||||..|..|
Mouse   508 RILRGPGDVVSIEILPGAAATPSGDDAQAPRVSTDSPSTAESIPEAASPPPPPPPPPPPLPNLQS 572

  Fly   357 --------------------PPPPPPINGAAPPPPPPPMI-NGGALPPPPPPPSMQMASRPRTPD 400
                                |||.||:.|..|||||||.: ..|.:|||||||    ...|  ||
Mouse   573 QQEAPPSAPPLAPPLPGCAEPPPAPPLPGDLPPPPPPPPLGTDGPVPPPPPPP----PGGP--PD 631

  Fly   401 PLAAEAVATAILLPQQDTPAPKAK--------MKTINWGKIPHNKVLGKQNIWSIVASNHQDSPM 457
            .|..:.....        |..|||        |..:||..:..:::.|     ::....:.:..:
Mouse   632 ILGGQGPDIG--------PGVKAKKPIQTKFRMPLLNWVALKPSQITG-----TVFTELNDEKVL 683

  Fly   458 QDIDWNEMEGLF-------CLQTASAQGSPKLGRDGSQAAAGSNGCDTLDRKSKKESTEITLLDG 515
            |::|.|:.|..|       ||..::.:|                      :.|:|..|:..|::.
Mouse   684 QELDMNDFEEHFKTKSQGPCLDISALKG----------------------KASQKAPTKTILIEA 726

  Fly   516 KRSLNVNIFLKQFRTSNDDIIQLIRQGAHEEIGAERLRGLLKIMPEVDELDMLKGFNGDK---AR 577
            .|:.|:.|.|::.....|.|.|.|.....:.:..:.|..|.:.:|...|..::..|..::   ..
Mouse   727 NRAKNLAITLRKGNLGADRICQAIETYDLQTLSLDFLELLTRFLPTDYERSLIARFEKEQRPMEE 791

  Fly   578 LGNAEKFLLQLLEVPNYKLRIESMLLKEEFAANVAYLEPCINSMLYAGDDLLNNKTLQEVLYMVV 642
            |...::|:|:...:.....|:.::.....|......|.|.:|:::.|...:.::..|:::|.:|:
Mouse   792 LSEEDRFMLRFSRIQRLPERMNTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEIVL 856

  Fly   643 VAGNFLNSGGYAGNAAGVKLSSLQKLTDIRANKPGMNLIHFVALQAEKRNPELLQFTGQLSNLES 707
            ..||::|| ...|.|.|.:|.||..|.::::......|:|::.....::.|:|..|...|..|:.
Mouse   857 AFGNYMNS-SKRGAAYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLDK 920

  Fly   708 ASKTTSEQINNEINTLDGRIRRIARQIEQPATDVDIKEQMADFLQAAESELSVLQAGMKQVESMR 772
            |...:.:.:..::.:|...:....|:..:....:.:||    ||:|....:..|.|..|..:...
Mouse   921 AGSVSLDSVLGDVRSLQRGLELTQREFVRQDDCLVLKE----FLRANSPTMDKLLADSKTAQEAY 981

  Fly   773 LKMSEFFCDDAATFRLEECFKIFHNFCDKFKQAVKENE-------------------------RR 812
            ..:.|:|.::..|......|.:|..|...:|:|.:|.|                         ||
Mouse   982 ESVVEYFGENPKTTSPSMFFSLFSRFTKAYKKAEQEVEQWKKEAAADTSGREEPPTPKSPPKARR 1046

  Fly   813 QQQEQQATLRRKQREEQLARRARQIGQAGTPVSDSEHSFLGDAIFDPRASPALSRRHLGSGEISN 877
            ||.:..:.|:|||::|.|...:.:.|.            :.|.|.|.|..|
Mouse  1047 QQMDLISELKRKQQKEPLIYESDRDGA------------IEDIITDLRNQP-------------- 1085

  Fly   878 GFIRLEQDGASPDITPNGSLRRR 900
             :||.:        |...|.|||
Mouse  1086 -YIRAD--------TGRRSARRR 1099

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
form3	NP_001097527.1	Drf_FH3	48..309	CDD:461885	46/281 (16%)
		FH2	415..803	CDD:396655	80/405 (20%)
		PTZ00449	<1145..1465	CDD:185628
Fmnl1	NP_001390541.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29
		Drf_GBD	28..299	CDD:461886	9/42 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	173..199
		Drf_FH3	302..>451	CDD:461885	33/210 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	526..646		42/133 (32%)
		FH2	647..1012	CDD:396655	77/396 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1021..1113		23/114 (20%)