Protein Alignment form3 and fhdc2

DIOPT Version :10

• Sequence 1: NP_001097527.1
• Gene: form3 / 3346238
• FlyBaseID: FBgn0053556
• Length: 1717
• Species: Drosophila melanogaster
• Sequence 2: XP_009306082.1
• Gene: fhdc2 / 569206
• ZFINID: ZDB-GENE-091118-76
• Length: 916
• Species: Danio rerio
• Alignment Length: 1121
• Identity: 292/1121 - (26%)
• Similarity: 464/1121 - (41%)
• Gaps: 287/1121 - (25%)

  Fly   351 MAPAAPPPPPPPINGAAPPPPPPPMINGGALPPPPPPPSMQMASRPRTPDPLAAEAVATAILLPQ 415
            ||..:.|.||.|     |||||||       |||.|||                   |:|..|.:
Zfish     1 MATISIPSPPIP-----PPPPPPP-------PPPLPPP-------------------ASASGLTR 34

  Fly   416 QDTPAPKAKMKTINWGKIPHNKVLGKQNIWSIVASNHQDSPMQDIDWNEMEGLFCLQTASAQGSP 480
            .|: ..|.:::.:||.:||..::.|:.|:||  .|..:||.: .||.|.::.||         ..
Zfish    35 VDS-GRKHRLRNLNWERIPKERIEGRNNVWS--GSLDEDSEL-TIDLNSLDELF---------GQ 86

  Fly   481 KLGRDGSQAAAGSNGC--DTLDRKSKKEST--EITLLDGKRSLNVNIFLKQFRTSNDDIIQLIRQ 541
            |.|:...:|    ||.  ..|..:|.:|.:  ::||||.|||:||.|||:|.:.:..::::.:|:
Zfish    87 KEGKKPERA----NGFRRSLLRCRSPQEISMDKVTLLDSKRSMNVGIFLRQLKIAAIEMVEDVRR 147

  Fly   542 GAHEEIGAERLRGLLKIMPEVDELDMLKGFNGDKARLGNAEKFLLQLLEVPNYKLRIESMLLKEE 606
            ||.|..|||:|..|.|::|:.:|...:|.||||::.|...:.|:|.|:|:|::::|::.|:|::|
Zfish   148 GAAERYGAEKLAELCKLLPDNEEEARVKKFNGDRSLLAEPDLFILLLVEIPSFRMRLDVMILQQE 212

  Fly   607 FAANVAYLEPCINSMLYAGDDLLNNKTLQEVLYMVVVAGNFLNSGGYAGNAAGVKLSSLQKLTDI 671
            |...|..|......:..|..:||:...|..:|.:|:.|||::|:|||||||||.::|||.||.|.
Zfish   213 FDPAVTSLCVAARCLREAARELLSCPELHYILRLVLKAGNYMNAGGYAGNAAGFRISSLLKLADT 277

  Fly   672 RANKPGMNLIHFVALQAEKRNPELLQFTGQLSNLESASKTTSEQINNEINTLDGRIR--RIARQI 734
            :||||||||:||||::..|::.:||.|:.:||::..||:.:.|.:..:.:.|..|:.  |:..|
Zfish   278 KANKPGMNLLHFVAMEVVKKDKDLLMFSSRLSHVSPASRLSEESVVEDFSRLQSRVADLRVRAQ- 341

  Fly   735 EQPATDVDIKEQMADFLQAAESELSVLQAGMKQVESMRLKMSEFFCDDAATFRLEECFKIFHNFC 799
                .|.:|::|...|||.||..|...|..::.::.....:.||||:|..||:|||...|||.||
Zfish   342 ----ADAEIEQQTRTFLQDAEVRLKEAQNELESLQQSSEALVEFFCEDDKTFKLEEACHIFHCFC 402

  Fly   800 DKFKQAVKENERRQQQEQQATLRRKQREEQLARRARQIG-----QAGTPVSDSEH------SFLG 853
            .:|::||:||..|:.|||    ||..||.:...:.|.:.     :|.....|.||      |:.|
Zfish   403 HRFQRAVQENTERELQEQ----RRVARERENVEKRRSLALCTGLEAERDSDDLEHALQRSLSYTG 463

  Fly   854 DAIFDPRASPALSRRHLGSGEISNGFIR-----LEQDGASPDIT------------PNGSLRRRR 901
                        |||.|  ..:|..|.|     |:.|...||..            ...||::..
Zfish   464 ------------SRRSL--RRLSQYFQRSEERNLKSDSQHPDSNLHLERSSRDSELKRHSLQKNE 514

  Fly   902 SRVLAEE--------------DDLMEFLRSSTGP-----HHDGHNSRERKAAYGSLDRSWARRAR 947
            ::...:|              |.:....:.:|.|     .|.|.|:|...:     |.::....:
Zfish   515 AKSEGKEQGMKMVKQALCLITDSMCGLQQDATAPPNTMKSHSGLNTRTVPS-----DNAFVALGK 574

  Fly   948 SGSSSRKRPDLLNIDFGMDRERASSPAPL----------LQQQQQNVQERLQSPLASTAGTPTTA 1002
            :..:|.             ::.|.:..||          :::|.|:..|||....|.  |:..:.
Zfish   575 TSIASH-------------QQGAVNVLPLTGLSPNKVLKVEKQVQHTSERLTQIAAD--GSEDSE 624

  Fly  1003 ANTPTGSGSAIAQ---TPSNNEDAKPRISREWRQKIETWLQSNESDEKQNEEYRRKRRLVNANRR 1064
            .|........::|   ||.........:.|      |||..::...|....       ||   :.
Zfish   625 KNNCVNGKECLSQKAVTPQTKSKKATNLER------ETWKSASSPPEASPP-------LV---QE 673

  Fly  1065 SLENETENERKLDPLPEEKILPSTTTATPTNTPTTTNPTNSTNRMDQESGKYQRVYADWKPSRTL 1129
            :...|.||..::....|...|.....:..:.:||.|.|  :||...:           ||..|..
Zfish   674 TSSPERENVYRVGETLECHTLVKGLRSYESLSPTVTRP--ATNHCSK-----------WKKEREA 725

  Fly  1130 EQTDVVANLQAIADAQPHDALRQHRRQRSQEQPSPIALQSIAEEDRRKSLIQKQGERDKSNERLQ 1194
            |:.:              .|...|.:..|:...||      .....::.|:.:.|
Zfish   726 EERE--------------GASSPHTKDDSRLVKSP------TRGPTKRLLVPRGG---------- 760

  Fly  1195 IYIRRSSSRELQPAKTEEHPLPPKSPKPQVSDDTFASLLSHHKTQNEMQGSSKDVDADNIETPPV 1259
                        |:.:...|......:|..||...||.:|                    ...||
Zfish   761 ------------PSNSSGIPRVRTKSEPTSSDALSASHIS--------------------RASPV 793

  Fly  1260 SRRVIATPTTT---------------VVTVSMTDKPKAATEEKINPAEQDAPGHFDRHALARRTR 1309
            ....|.|...|               |.|.:.|.|.|..:.||:|..:......|.|.:..|..:
Zfish   794 RTTAIRTSLMTRFAGGQNELKPNRQKVNTQAETGKQKGNSAEKLNQDKDKGREQFVRGSPLRVPK 858

  Fly  1310 RYKRPTDYSSGNEEALTTSTAEAKTSPSKPEPPAPEKSKQKERTINKLEKVGRHISSINQEDVRE 1374
            |.       :.|.|:.|:.|..:.|:.:            ..:||..     ..||:...:....
Zfish   859 RL-------APNSESQTSHTIHSPTTAT------------TAKTIRT-----AIISAAKAKSPGT 899

  Fly  1375 AIRNLKSPTGTPERPW 1390
            .|..||.|..|.:..|
Zfish   900 RIPGLKIPRATTQPSW 915

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
form3	NP_001097527.1	Drf_FH3	48..309	CDD:461885
		FH2	415..803	CDD:396655	144/393 (37%)
		PTZ00449	<1145..1465	CDD:185628	47/261 (18%)
fhdc2	XP_009306082.1	FH2	40..406	CDD:396655	143/386 (37%)
		Smc	<316..>522	CDD:440809	63/228 (28%)