Protein Alignment form3 and fhdc4

DIOPT Version :10

• Sequence 1: NP_001097527.1
• Gene: form3 / 3346238
• FlyBaseID: FBgn0053556
• Length: 1717
• Species: Drosophila melanogaster
• Sequence 2: XP_694558.2
• Gene: fhdc4 / 566196
• ZFINID: ZDB-GENE-131127-25
• Length: 752
• Species: Danio rerio
• Alignment Length: 913
• Identity: 257/913 - (28%)
• Similarity: 404/913 - (44%)
• Gaps: 234/913 - (25%)

  Fly   343 TPPPPPPPMAPAAPPPPPPPINGAAPPPPPPPMINGGALPPPPPPPSMQMASRPRTPDPLAAEAV 407
            ||||||||     |||||||    .|||||.|...||..                |..|..|
Zfish     2 TPPPPPPP-----PPPPPPP----PPPPPPAPFPGGGQF----------------TRGPTRA--- 38

  Fly   408 ATAILLPQQDTPAPKAKMKTINWGKIPHNKVLGKQNIWSIVASNHQDSPMQDIDWNEMEGLFCLQ 472
                           :.|:..||..||.|.||||.|||:      :.:...::|...||.||
Zfish    39 ---------------STMRNFNWEPIPKNNVLGKTNIWT------EKNREFELDTKRMEELF--- 79

  Fly   473 TASAQGSPKLGRDGSQAAAGSNGCDTLDRKSKKESTE-------ITLLDGKRSLNVNIFLKQFRT 530
                      .|...:....||      |:|.::|..       :::|:.|:|:|:.|||||||.
Zfish    80 ----------SRVDQKQVQNSN------RRSIRQSPTNAPGNEMVSILNAKKSMNIGIFLKQFRR 128

  Fly   531 SNDDIIQLIRQGAHEEIGAERLRGLLKIMPEVDELDMLKGFNGDKARLGNAEKFLLQLLEVPNYK 595
            |.:.:|:.|..|..::.|..:|:.:.|::||..|:..|:.|.||.:.|..|::|::||::||.|:
Zfish   129 SVNGMIEDIVNGRGDKFGPGKLKEMCKLLPEEGEVRQLRDFKGDPSVLSEADRFMVQLVKVPCYE 193

  Fly   596 LRIESMLLKEEFAANVAYLEPCINSMLYAGDDLLNNKTLQEVLYMVVVAGNFLNSGGYAGNAAGV 660
            .|:..::|||||...:..:...|..|..||.:||:...|..|:.:|:..||::|||||||:|.|.
Zfish   194 ERLNCLVLKEEFPHFMDEVSHAIAVMTSAGRELLDCADLHSVIRLVLKTGNYMNSGGYAGSAVGF 258

  Fly   661 KLSSLQKLTDIRANKPGMNLIHFVALQAEKRNPELLQFTGQLSNLESASKTTSEQINNEINTLDG 725
            :::||.||.|.:||||||||:|:|.:||:|.:..||:|..||.|:..|::...::|..:...
Zfish   259 RITSLLKLADTKANKPGMNLMHYVVMQAQKIDAALLKFPEQLQNIGDAARIHKQEIETDFQK--- 320

  Fly   726 RIRRIARQIEQPATDVDIKEQMADFLQAAESELSVLQAGMKQVESMRLKMSEFFCDDAATFRLEE 790
            .|.::.:..|..:...|::|||.||||.||:.:..::...|.:.::...::::||:|...|:|||
Zfish   321 EISKVQKSKENASKQPDLEEQMRDFLQNAETRIQEMEESFKMLSAVSDSVAQYFCEDPTQFKLEE 385

  Fly   791 CFKIFHNFCDKFKQAVKENERRQQQEQQATLRRKQRE-EQLARRARQIGQAGTPVSDSEHSFLGD 854
            |..||::||:|||:||:||..|...|    ::|:||| .|.|.:.|......:...|.|.:.|..
Zfish   386 CCSIFYSFCEKFKRAVQENLDRDILE----VKRRQREGSQNAAKRRSTATCSSRDKDIEGAALES 446

  Fly   855 AIFDPRASPALSRRHLGSGEISNGFIRLEQDGASPDITPNGSLRRRRSRVLAEEDDLMEFLRSST 919
            .:  .|.:...|||..|:              |||.:   |:|           .|:::
Zfish   447 IL--QRFNSRQSRRRAGN--------------ASPTL---GNL-----------TDILQ------ 475

  Fly   920 GPHHDGHNSRERKAAYGSLDR-SWARRARSGSSSRKRPDLLNIDFGMDRERASSPAPLLQQQQQN 983
                      |.:.|..::.| ||.:.|...|..::         ..:||          :..:|
Zfish   476 ----------ENRPADRAVKRDSWIKGALQSSVIKE---------SFERE----------EMPKN 511

  Fly   984 VQERLQSPLASTAGTPTTAANTPTGSGSAIAQTPSNNED-----AKPRISREWRQKIETWLQSNE 1043
            .|..:.||...|..||.:..|      ..::.|...:||     .:.|..||..:|:..: ||::
Zfish   512 PQITISSPAHETPSTPNSTVN------QRLSVTTEQDEDDVQTEKEVRNMREVSRKVLQY-QSSK 569

  Fly  1044 SDEKQNE--------------EYRRKRRLV-----NANRRSLENETE--NERKLDPLP------- 1080
            |.....|              |.||:..:|     .||..||...::  |.|....||
Zfish   570 SSISSGEALSPLLSPRQTFFQEDRRQLLIVAIEENTANSSSLLQNSQIINRRHTISLPEANCGNA 634

  Fly  1081 --EEKILPSTTTATP-------------------TNTPTTTNPTNSTNR-MDQESGKYQRVYADW 1123
              |:..:|....|:|                   |...:|...:||.|. ...||.:.::..|
Zfish   635 SQEDIFVPCNLNASPAPSIDAIGKVKSLDSAILSTQQNSTVKDSNSQNESQSTESPQLEKSEA-- 697

  Fly  1124 KPSRTLEQTDVVANLQAIADAQPHDALRQHRRQRSQEQPSPIALQSIAEEDRRKSLIQKQGERDK 1188
                  :..|.|.|:|.           ...::.||    .::.:|..|.....||.::..|:||
Zfish   698 ------KTEDTVPNMQF-----------NGGKRNSQ----TVSFKSAKEGFSFMSLFKRWREKDK 741

  Fly  1189 SNE 1191
            |.|
Zfish   742 SKE 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
form3	NP_001097527.1	Drf_FH3	48..309	CDD:461885
		FH2	415..803	CDD:396655	135/394 (34%)
		PTZ00449	<1145..1465	CDD:185628	11/47 (23%)
fhdc4	XP_694558.2	FH2	41..398	CDD:418645	135/384 (35%)