Protein Alignment form3 and diaph2

DIOPT Version :10

• Sequence 1: NP_001097527.1
• Gene: form3 / 3346238
• FlyBaseID: FBgn0053556
• Length: 1717
• Species: Drosophila melanogaster
• Sequence 2: XP_021336921.1
• Gene: diaph2 / 556029
• ZFINID: ZDB-GENE-090115-1
• Length: 1166
• Species: Danio rerio
• Alignment Length: 1109
• Identity: 252/1109 - (22%)
• Similarity: 429/1109 - (38%)
• Gaps: 331/1109 - (29%)

  Fly     1 MDSRIGLDYIVENRDYIAKLGAALDTQNATVKKQVFELLSALCAYSPDGY---ARAIETLEFYKN 62
            |:::.||..|:.:...:..|..|:|.:...:..::.::|||:|....:..   ..|..|:...:|
Zfish   233 MNNKYGLQRILGDERSLLLLARAIDPKQTNMMTEIVKILSAVCIIGEENILDKILAAMTIAAERN 297

  Fly    63 LKKQRYRFKIVINELELSSAAAHPPLDYQAALLAFINCVIISAATLQERIRIRNEFI--GL-KVL 124
            .|:   ||..::..||     .|.....|.|.:..||.::.|...|..||.:||||:  || |:|
Zfish   298 NKE---RFAPIVEGLE-----NHEAQQLQVACMQLINALVTSPDDLDFRIHLRNEFLRCGLKKIL 354

  Fly   125 PLLNNLRLLEAGNVESSASPSPPPSLSSESASSATSPVSGSASTSVTPSPSPLHLQRRLTFCGSL 189
            |.|.....|:
Zfish   355 PELKETEELD------------------------------------------------------- 364

  Fly   190 SRYSCAALQLVQNLKKVAQSVGDIIVQLDVFVEQQECDEAQSLQAPDGINLNSHLD--------- 245
                                     :||.||.|.:|         .|.|.|:..||
Zfish   365 -------------------------IQLKVFNENKE---------EDSIELSHRLDDIRAEMDDM 395

  Fly   246 --VFYAILRQVADTPQEVPFLNILQHLLRIDP------------KEPLSDIIWDTT--------- 287
              |::.:...|.||..|..||:||||||.|..            :|.:|.|:...:
Zfish   396 GEVYHLLSNMVKDTGSEPYFLSILQHLLLIRNDYYIRPQYYKVIEECVSQIVLHRSGMDPDFAYR 460

  Fly   288 ERL-----------VHRATLLESHEDSVRLLRTPSSQKFACQSCRGSDASSPTRKPSQPV----- 336
            |||           |.:|.:.||.:.:...     |:||..:.....:|.:..:|..:.:
Zfish   461 ERLDVDFSHLIDQCVDKAKVDESEQRAAEF-----SKKFDEEFSARQEAQAELQKQEEKIKAFES 520

  Fly   337 ---------------------GVSAKTT-------------PPPPPPP---MAPAAPPPPPPPIN 364
                                 .:|.:.:             |||||||   ..|..||||||||.
Zfish   521 QINTLQAQLTSERDKLKEAEKSISERNSKIAAGPKAAGAGPPPPPPPPGGIAPPPPPPPPPPPIG 585

  Fly   365 GAAPPPPPPPMINGGALPPPPPPPSM--------------QMASRPRTPDPLAAEAVATAILLP- 414
            ||.|||||||.......|||||||..              .....|..|.||..:       ||
Zfish   586 GAPPPPPPPPFPASLGPPPPPPPPGCGPPPPPPPPGGGPPPPPGMPSAPPPLVVQ-------LPY 643

  Fly   415 ---QQDTPAPKAKMKTINWGKIPHNKVLGKQNIWSIVASNHQDSPMQDIDWNEMEGLFCLQTASA 476
               .:.|..|.:.||.:||.||...: :.:...|..|    ::...::.|      :|...:.|.
Zfish   644 GLAPKKTYKPDSIMKRVNWSKIVPQE-MAENCFWLKV----KEERFENTD------MFSELSLSF 697

  Fly   477 QGSPKLGRDGSQAAAGSNGCDTLDRKS--KKESTEITLLDGKRSLNVNIFLKQFRTSNDDIIQLI 539
            ....::.:|..         :|.||.:  ||::.|:.:||.|.:.|::|||..||...::|..::
Zfish   698 SSKSRVKKDVE---------ETDDRMTQFKKKAKELRILDAKTAQNLSIFLGSFRLPYEEIRDIV 753

  Fly   540 RQGAHEEIGAERLRGLLKIMPEVDELDMLKGFNGDKARLGNAEKFLLQLLEVPNYKLRIESMLLK 604
            .|...|.:....::.|:|.:||..||..|.....:...|..:|:|.:.:..|...:.|:..:|.|
Zfish   754 LQVDEERLSEALIQNLIKNLPEQKELSNLAELKNEYEELCESEQFGIVMSSVKMLRPRLNGILFK 818

  Fly   605 EEFAANVAYLEPCINSMLYAGDDLLNNKTLQEVLYMVVVAGNFLNSGGYAGNAAGVKLSSLQKLT 669
            ..|...|..:.|.|.::.:|.:::..::....:|.||::.||::|||.......|..:|.|.||.
Zfish   819 LTFEEQVNNIRPDIMNVTFACEEVKKSEGFHMLLEMVLLVGNYMNSGSRNAQTFGFNISFLCKLR 883

  Fly   670 DIRANKPGMNLIHFVALQAEKRNPELLQFTGQLSNLESASKTTSEQINNEINTLDGRIRRIARQI 734
            |.::......|:||:|.:.|::.||:|:|..:|.::|||||..::.:...::.::..|:|:...|
Zfish   884 DTKSTDQNTTLLHFLAEKCEEKYPEMLKFPDELEHVESASKVAAQTLKASLDIMERHIQRLENDI 948

  Fly   735 EQ-PATD---VDIKEQMADFLQAAESELSVLQAGMKQVESMRLKMSEFFCDDAATFRLEECFKIF 795
            :. |.||   ....|:|:.|.:.:..:...|....|.::.:...:..:|..|..|..:|:.|...
Zfish   949 QNFPKTDDKQDKFVEKMSGFSKHSREQYEKLSTMHKNMQKLYENLGSYFAFDPHTVSIEDFFGDL 1013

  Fly   796 HNFCDKFKQAVKENERRQQQE-------------QQATLRRKQREEQLARRARQIGQAGTPVSDS 847
            .||.:.|..||:||.::::.|             ::..:.|:|:::||....::..:.|  |.||
Zfish  1014 ANFRNLFMDAVRENHKKREMEEKIKRAKIAKEKAEREKIERQQKKKQLIDMNKEGDETG--VMDS 1076

  Fly   848 EHSFLGDAIFDPRASPALSRRHLGSGEISNGFIRLEQDGASPDITPNGSLRRRRSRVLAEEDDLM 912
                |.:|:                           |.||        :.|.||.|.....|
Zfish  1077 ----LMEAL---------------------------QSGA--------AFRDRRKRTPRNGD--- 1099

  Fly   913 EFLRSST-------GPHHDGHNSRERKAA--------------YGSLD----RSWAR--RARSGS 950
               :|.:       |.:||..:.:.|:.:              ||.:.    |::|:  |.:||.
Zfish  1100 ---QSPSCSAPRWPGANHDAASGKSRQPSHWFGKIPFAPQCKPYGPMIACRLRTFAKCQRPKSGD 1161

  Fly   951 SSRK 954
            ::.:
Zfish  1162 NTEE 1165

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
form3	NP_001097527.1	Drf_FH3	48..309	CDD:461885	63/309 (20%)
		FH2	415..803	CDD:396655	98/393 (25%)
		PTZ00449	<1145..1465	CDD:185628
diaph2	XP_021336921.1	Drf_GBD	86..276	CDD:461886	10/42 (24%)
		Drf_FH3	284..470	CDD:461885	59/282 (21%)
		EnvC	477..>545	CDD:443969	8/72 (11%)
		FH2	647..1020	CDD:396655	98/392 (25%)