Protein Alignment form3 and Diaph2

DIOPT Version :10

• Sequence 1: NP_001097527.1
• Gene: form3 / 3346238
• FlyBaseID: FBgn0053556
• Length: 1717
• Species: Drosophila melanogaster
• Sequence 2: XP_006528644.1
• Gene: Diaph2 / 54004
• MGIID: 1858500
• Length: 1109
• Species: Mus musculus
• Alignment Length: 1019
• Identity: 241/1019 - (23%)
• Similarity: 421/1019 - (41%)
• Gaps: 250/1019 - (24%)

  Fly     1 MDSRIGLDYIVENRDYIAKLGAALDTQNATVKKQVFELLSALCAYSPD--------GYARAIETL 57
            |:::.||..|:.:...:..|..|:|.:...:..::.::|||:|....:        |...|.|.
Mouse   251 MNNKFGLQRILGDERSLLLLARAIDPKQQNMMTEIVKILSAICIVGEENILDKLLGGITAAAEL- 314

  Fly    58 EFYKNLKKQRYRFKIVINELELSSAAAHPPLDYQAALLAFINCVIISAATLQERIRIRNEFIGLK 122
                   ..|.||..::..||.:.|     |..|.|.:.|||.::.|...|..||.:||||:
Mouse   315 -------NNRERFSPIVEGLENNEA-----LHLQVACMQFINALVTSPYDLDFRIHLRNEFL--- 364

  Fly   123 VLPLLNNLRLLEAGNVESSASPSPPPSLSSESASSATSPVSGSASTSVTPSPSPLHLQRRLTFCG 187
                                                                             
Mouse   365 ----------------------------------------------------------------- 364

  Fly   188 SLSRYSCAALQLVQNLKKVAQSVGDIIVQLDVFVEQQECDEAQ------SLQAP-DGINLNSHLD 245
                 .|....::..||::.....||  ||.||.|.:|.|.::      .::|. |.||     :
Mouse   365 -----RCGLKAMLPTLKEIENEGLDI--QLRVFEENKEDDLSELSHRLNDIRAEMDDIN-----E 417

  Fly   246 VFYAILRQVADTPQEVPFLNILQH--LLRID----P------KEPLSDII--------------- 283
            |::.:...:.||..|...|:||||  |:|.|    |      :|.:|.|:
Mouse   418 VYHLLYNMLKDTAAEPYLLSILQHFLLIRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQR 482

  Fly   284 --WDTTERL---VHRATLLESHEDSVRLLRTPSSQKFACQSCRGSDASSPTRKPSQPV------- 336
              :|.|..|   |::|.:.|:.:.::..     |:||..:.....:|.:..:|..:.:
Mouse   483 IDFDFTHLLDACVNKAKVEENEQKAMEF-----SKKFDEEFTARQEAQAELQKRDEKIKELETEI 542

  Fly   337 ------GVSAKTTPPPPPPPM-------APAAPPPPPPPINGAAPPPPPP-PMINGGALPPPPPP 387
                  ||.:....||||||:       .|..|||||||:.|..|||||| |.:.|  :||||||
Mouse   543 QQLRGQGVPSAIPGPPPPPPLPGAGPCPPPPPPPPPPPPLPGVVPPPPPPLPGMPG--IPPPPPP 605

  Fly   388 PSMQMASRPRTPD---PLAAEAVATAILLPQQDTPAPKAKMKTINWGKIPHNKVLGKQNIWSIVA 449
            |...:...|..|.   ||.:..:.....:.|:....|...||.|||.|| ..|.|.:..:|..:
Mouse   606 PLSGVPPPPPPPGGVFPLLSGPIELPYGMKQKKLYKPDIPMKRINWSKI-EPKELSENCVWLKL- 668

  Fly   450 SNHQDSPMQDIDWNEMEGLFCLQTASAQGSPKLGRDGSQAAAGSNGCDTLDRKSKKESTEITLLD 514
               ::...::.|      ||.....:.....|..|:...|....:|      ..||:..|:.:||
Mouse   669 ---KEEKYENAD------LFAKLALTFPSQMKGQRNTEAAEENRSG------PPKKKVKELRILD 718

  Fly   515 GKRSLNVNIFLKQFRTSNDDIIQLIRQGAHEEIGAERLRGLLKIMPEVDELDMLKGFNGDKARLG 579
            .|.:.|::|||..:|...::|..:|.:...|.:....::.|:|.:|:.:.|..|.....:...|.
Mouse   719 TKTAQNLSIFLGSYRMPYEEIKNIILEVNEEMLSEALIQNLVKYLPDQNALRELAQLKSEYDDLC 783

  Fly   580 NAEKFLLQLLEVPNYKLRIESMLLKEEFAANVAYLEPCINSMLYAGDDLLNNKTLQEVLYMVVVA 644
            ..|:|.:.:..|...:.|:.|:|.|..|..:|..::|.|.::..|.::|..:::.:.:|.::::.
Mouse   784 EPEQFGVVMSTVKMLRPRLTSILFKLTFEEHVNNIKPSIIAVTLACEELKKSESFKRLLELILLV 848

  Fly   645 GNFLNSGGYAGNAAGVKLSSLQKLTDIRANKPGMNLIHFVALQAEKRNPELLQFTGQLSNLESAS 709
            ||::|||.....:.|.|::.|.|:.|.::......|:||:|...:::..::|:|..:|.::|||.
Mouse   849 GNYMNSGSRNAQSLGFKINFLCKIKDTKSADQKSTLLHFLAEICDEKYRDILKFPDELEHVESAG 913

  Fly   710 KTTSEQINNEINTLDGRIRRIARQIEQ--PATDVDIK--EQMADFLQAAESE---LSVLQAGM-K 766
            |.:::.:.:.:..::..|..:.:.|:.  ||.....|  |:|..|.|.|..:   ||.:.:.| |
Mouse   914 KVSAQILKSNLVAMEQSILHLEKNIKNFPPAESHHDKFVEKMMSFTQNAREQYDKLSTMHSNMLK 978

  Fly   767 QVESMRLKMSEFFCDDAATFRLEECFKIFHNFCDKFKQAVKENERRQQQEQQA----TLRRKQRE 827
            ..||    :.|:|..|..|..:||.|...:.|...|.:|:|||.:|::.|:::    ..:.|..:
Mouse   979 LYES----LGEYFIFDPNTVNMEEFFGDLNTFRTLFLEALKENHKRKEMEEKSRRAKLAKEKAEQ 1039

  Fly   828 EQLARRARQ-----IGQAG--TPVSDSEHSFLGDAIFDPRASPALSRRHLGSGEISNGFIRLEQD 885
            |:|.|:.::     |.:.|  |.|.|:    |.:|:                           |.
Mouse  1040 EKLERQKKKKQLIDINKEGDETGVMDN----LLEAL---------------------------QS 1073

  Fly   886 GASPDITPNGSLRRRRSRVLAEEDDLMEFLRSSTGPHHDGHNSR 929
            ||        :.|.||.|:....|:....|..|...|:...:|:
Mouse  1074 GA--------AFRDRRKRIPRNPDNRRPPLERSRSRHNGAMSSK 1109

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
form3	NP_001097527.1	Drf_FH3	48..309	CDD:461885	61/307 (20%)
		FH2	415..803	CDD:396655	98/395 (25%)
		PTZ00449	<1145..1465	CDD:185628
Diaph2	XP_006528644.1	Drf_GBD	102..294	CDD:461886	10/42 (24%)
		Drf_FH3	302..490	CDD:461885	57/280 (20%)
		FH2	636..1010	CDD:396655	98/394 (25%)