Protein Alignment form3 and fmnl1

DIOPT Version :10

• Sequence 1: NP_001097527.1
• Gene: form3 / 3346238
• FlyBaseID: FBgn0053556
• Length: 1717
• Species: Drosophila melanogaster
• Sequence 2: NP_001007523.1
• Gene: fmnl1 / 493573
• XenbaseID: XB-GENE-1003193
• Length: 1167
• Species: Xenopus tropicalis
• Alignment Length: 991
• Identity: 213/991 - (21%)
• Similarity: 388/991 - (39%)
• Gaps: 163/991 - (16%)

  Fly     1 MDSRIGLDYIVENRDYIAKLGAALDTQNATVKKQVFELLSALCAYSPDGYARAIETLEFYKNLKK 65
            |:.:.|...::.:...:.|:..:|..:|...|..|.|||:|:|... .|:...:....::..:..
 Frog   240 MNYQSGFSMVMSHSSCVNKITLSLSNKNPRTKALVLELLAAVCLVR-GGHELILSAFNYFMEMCG 303

  Fly    66 QRYRFKIVINELELSSAAAHPPLDYQAALLAFINCVIISAATLQERIRIRNEFIGLKVLPLLNNL 130
            :..||:.::.......:    .:|:..|.:.|||.|:.|...:..|:.::.||   .:|.|...|
 Frog   304 EGARFEKLMEYFRTEDS----NIDFMVACMQFINIVVHSVKNMNFRVFLQYEF---TLLGLDEYL 361

  Fly   131 RLLEAGNVESSASPSPPPSLSSESASSATSPVSGSASTSVTPSPSPLH---LQRRLTFCGSLSRY 192
            .:|:  |.||...     .:..::.......|:.....:.|.:....|   ||..||      |.
 Frog   362 EILK--NTESERL-----QVQIQAYLDNIFDVNSLLEDTDTKNEMLEHVEDLQEHLT------RV 413

  Fly   193 SCAALQLVQNLKKVAQSVGDIIVQLD-VFVEQQECDEAQSLQAPD-------------------- 236
            : ..|||.:|  :..:.|.::..||| ...|.....|...:|||.
 Frog   414 T-EKLQLTEN--EYVRRVAELEKQLDQCRREMSSAKEKLVVQAPQVTQNIVQRTELVKRSVLWVE 475

  Fly   237 --GINLNSHL--DVFYAILRQVADTPQEVPFLNILQHLLRIDPKEPLSDIIWD--TTERLVHRAT 295
              |......:  :.|.:.|...|.||   |.......:..|.|....:|.:..  .:.|......
 Frog   476 PAGDTCTEEISDNTFTSDLPSAASTP---PLSPSAIRITLISPSVTSTDALSSRGNSPRSTTPPA 537

  Fly   296 LLESHEDSVRLLRTPS--------------------------------SQKFACQSCRGSDASSP 328
            ||.|..:|..:...|:                                :|....||...:...||
 Frog   538 LLPSLPESSEIFSIPAPSPVPSSEDSSDTALKASKVNPVPSPPSIIDQTQTSNAQSLSRTHDESP 602

  Fly   329 TRKPSQPVGVSAKTTPPPPPPPMAPAAPPPPP-PPINGAAPP----------PPPPPMINGGALP 382
            ...|..|: .|....|||||.||:...||||| |.::|..||          |||||.:....:|
 Frog   603 PPPPPPPL-PSIAEIPPPPPLPMSADVPPPPPLPELSGIPPPPPLPMGEQGAPPPPPSMGAPGVP 666

  Fly   383 PPPPPPSMQMASRPRTP---DPLAAEAVATAILLPQQDTPAPKAKMKTINWGKIPHNKVLGKQNI 444
            ||||||.......|..|   .|.|......:|..|.|    .|.:|:.:||..:...::.|
 Frog   667 PPPPPPPSGFGPAPPPPPGGQPAATLNTGVSIKKPIQ----TKLRMQVLNWVALKPTQING---- 723

  Fly   445 WSIVASNHQDSPMQDIDWNEMEGLFCLQTASAQGSPKLGRDGSQAAAGSNGCDTLDRKSKKESTE 509
             ::....:.:..:|::|.::.|..|   ...||| |.......:..|..|           :..:
 Frog   724 -TVFTHLNDEKVLQELDMSDFEENF---KTKAQG-PSQTTFSMKVKAAQN-----------QPNK 772

  Fly   510 ITLLDGKRSLNVNIFLKQFRTSNDDIIQLIRQGAHEEIGAERLRGLLKIMPEVDELDMLKGFNGD 574
            ::|::..|:.|:.|.|::...|.:.|...|::...:....:.|..|.:.:|...|...:..:..|
 Frog   773 VSLIETNRAKNLAITLRKGGLSPEAITSAIQKYDMQAFNMDFLELLARFLPTDWERQQISRYCRD 837

  Fly   575 KARLGN---AEKFLLQLLEVPNYKLRIESMLLKEEFAANVAYLEPCINSMLYAGDDLLNNKTLQE 636
            :..|.:   .::|::.|..:|....|:.:|.....|....:.|:|.:::::.|...:.::..|:.
 Frog   838 QKPLDDLTAEDRFMVHLCSIPRLAERVNTMTFMANFPDMASRLKPQLDALIAASMSIKSSDKLKG 902

  Fly   637 VLYMVVVAGNFLNSGGYAGNAAGVKLSSLQKLTDIRANKPGMNLIHFVALQAEKRNPELLQFTGQ 701
            :|.:|:..||::|| ...|.|.|.:|.||..|.:.::......|:|::.....::...|..|...
 Frog   903 ILELVLAFGNYMNS-SKRGAAYGFRLQSLDVLLETKSTDRKQTLLHYMIRVICEKYSHLSNFYCD 966

  Fly   702 LSNLESASKTTSEQINNEINTLDGRIRRIARQIEQPATDVDIKEQMADFLQAAESELSVLQAGMK 766
            |:.::.|:..:.:.:..::.:|...:    .|:::..|..|....:.||:::....|..|.|..|
 Frog   967 LNFMDKAATVSLDSVLADVKSLQAGM----EQVQKEFTKQDDCLILKDFIKSNMDSLKQLSADAK 1027

  Fly   767 QVESMRLKMSEFFCDDAATFRLEECFKIFHNFCDKFKQAVKENERRQQQE---QQA---TLRRKQ 825
            ..:........:|.::|.|......|.||..|...:|||.::.|..::||   |:|   |..::.
 Frog  1028 TAQEAYDAAVGYFGENAKTTPPSTFFPIFVRFIKAYKQAEQDLETWKKQESAVQEAKPETAGKQA 1092

  Fly   826 REEQLARRAR-QIG---------QAGTPVSDSEHSFLGDAIFDPRASPALSRRHLG--SGEISNG 878
            .:..:.:..| |:.         |...|....::..:.|.|.|.|..| ..|..:|  ||:
 Frog  1093 PQSPVVKSLRPQVNLMAELNKKLQTKEPRVYEQNWAIEDIITDLRNQP-YRRTDVGRRSGK---- 1152

  Fly   879 FIRLEQDGASPDITPN 894
                :|:...|..||:
 Frog  1153 ----KQNSGQPLNTPD 1164

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
form3	NP_001097527.1	Drf_FH3	48..309	CDD:461885	56/290 (19%)
		FH2	415..803	CDD:396655	76/390 (19%)
		PTZ00449	<1145..1465	CDD:185628
fmnl1	NP_001007523.1	Drf_GBD	37..283	CDD:461886	11/42 (26%)
		Drf_FH3	286..>423	CDD:461885	32/159 (20%)
		FH2	698..1064	CDD:396655	78/394 (20%)