Protein Alignment form3 and fmnl3

DIOPT Version :10

• Sequence 1: NP_001097527.1
• Gene: form3 / 3346238
• FlyBaseID: FBgn0053556
• Length: 1717
• Species: Drosophila melanogaster
• Sequence 2: NP_001333083.1
• Gene: fmnl3 / 407694
• ZFINID: ZDB-GENE-030131-1571
• Length: 1047
• Species: Danio rerio
• Alignment Length: 904
• Identity: 196/904 - (21%)
• Similarity: 385/904 - (42%)
• Gaps: 138/904 - (15%)

  Fly     1 MDSRIGLDYIVENRDYIAKLGAALDTQNATVKKQVFELLSALCAYSPDGYARAIETLEFYKNLKK 65
            |:.:.|.:.::.:...:.::..:|:.:|...|..|.|||:|:|... .|:...:...:.:|.:.|
Zfish   225 MNYQYGFNLVMSHAHAVNEIALSLNNKNPRTKALVLELLAAVCLVR-GGHEIILSAFDNFKEVCK 288

  Fly    66 QRYRFKIVINELELSSAAAHPPLDYQAALLAFINCVIISAATLQERIRIRNEFIGLKVLPLLNNL 130
            :::||:.::........    .:|:..|.:.|||.|:.|...:..|:.::.||..|.:...|.
Zfish   289 EKHRFEKLMEYFRSEDG----NIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLDDFLE-- 347

  Fly   131 RLLEAGNVESSASPSPPPSLSSESASSATSPVSGSASTSVTPSPSPLHLQRRLTFCGSLSRYSCA 195
                    :|..:.|...|:..::.......|.|....:.|.:                     .
Zfish   348 --------KSKHTESDKLSVQIQAYLDNVFDVGGLLEDAETKN---------------------V 383

  Fly   196 ALQLVQNLKKVAQSVGDIIVQLDVFVEQQECD-EAQSLQAPDGINLNSHLDVFYAILRQVADTPQ 259
            ||:.|:.|::....|.:.::.::.....:..| |.|.|          |.|...|::::..::
Zfish   384 ALEKVEELEEHLSHVTEKLLDVENETMTKVADLEKQLL----------HKDKELAVIKETYES-- 436

  Fly   260 EVPFLNILQHLLRIDPKEPLSDIIWDTTERLVHRATLLESHEDSVRLLRTPSSQKFACQSC-RGS 323
                .:...|.||...:|  .|..:.....:..:...|| .:.::||.:.|... .|.::. .|:
Zfish   437 ----ASTQVHTLRRMIQE--KDAAFQRHNNIEKQLLELE-QQGTIRLRKQPDGD-IAIETLGAGA 493

  Fly   324 DASSP-TRKPSQPVGVS------------AKTTPPPPPPPMAPAAPPPPPPPINGAAPPPPPPPM 375
            .|.:| |...|..||:|            .:...||||||     |||||||     |.||.|..
Zfish   494 VAGTPLTDLRSLTVGMSTIGGLGGTSAVPVEAVAPPPPPP-----PPPPPPP-----PAPPLPSE 548

  Fly   376 INGGALPPPPPPPSMQMASRPRTPDPLAAEAVATAILLPQQDTP-APKAKMKTINWGKIPHNKVL 439
            :....:|||||||         .|.|..:..::..:...:...| ..|.::...||..:..|::.
Zfish   549 VESIPIPPPPPPP---------LPGPSPSVILSVGLSAIRIKKPIKTKFRLPVFNWTALKPNQIN 604

  Fly   440 GKQNIWSIVASNHQDSPMQDIDWNEMEGLFCLQTASAQGSPKLGRDGSQAAAGSNGCDTLDRKSK 504
            |     ::......|..::::|..:.|.||   ...||| |.:....|::           :.|:
Zfish   605 G-----TVFNEIDDDRVLEELDLEKFEELF---KTKAQG-PVVDLSCSKS-----------KVSQ 649

  Fly   505 KESTEITLLDGKRSLNVNIFLKQFRTSNDDIIQLIRQGAHEEIGAERLRGLLKIMPEVDELDMLK 569
            |...::.|||..||.|:.|.|::...:.::|.:.|:....:.:..:.:..|::.:|...|..:|:
Zfish   650 KVINKVQLLDANRSKNLAITLRKANKTTEEICKAIQTFDLKALPVDFVECLMRFLPTEAESKLLR 714

  Fly   570 GFNGDKA---RLGNAEKFLLQLLEVPNYKLRIESMLLKEEFAANVAYLEPCINSMLYAGDDLLNN 631
            .:..::.   :|...::|:|...::.....|:..:.....|..||..|.|.:|:::.|...:.::
Zfish   715 QYERERRPLDQLAEEDRFMLLFSKIERLTQRMSIITFVGNFNDNVNMLTPQLNAIIAASASVKSS 779

  Fly   632 KTLQEVLYMVVVAGNFLNSGGYAGNAAGVKLSSLQKLTDIRANKPGMNLIHFVALQAEKRNPELL 696
            ..|:::|.:::..||::|| ...|:..|.||.||..|.|.::....|.|:|::||..:::.|||.
Zfish   780 PKLKKILEIILALGNYMNS-SKRGSVYGFKLQSLDLLLDTKSTDRKMTLLHYIALVVKEKYPELA 843

  Fly   697 QFTGQLSNLESASKTTSEQINNEINTLDGRIRRIARQIEQPATDVDIKEQMADFLQAAESELSVL 761
            .|..:|..::.|:..:.|.:..::..|...:..:.|:.......|     :..|.|.::::|..|
Zfish   844 NFYNELHFVDKAAAVSLENVLLDVKELGKGMDLVRRECSLHDHAV-----LKGFAQTSDTQLDKL 903

  Fly   762 QAGMKQVESMRLKMSEFFCDDAATFRLEECFKIFHNFCDKFKQAVKENERRQQQEQ--------- 817
            ....|..|.....:..:|.:...|......|.:|..|...:|:||:|||:|::||:
Zfish   904 AKDAKTAEEAFNNVVLYFGESPKTTPPSVFFPVFVRFIRAYKEAVEENEQRKKQEEAMREKLLAQ 968

  Fly   818 ---------QATLRRKQREEQLARRARQIGQAGTPVSDSEHSFLGDAIFDPRASPALSR 867
                     ||..:|.|::|.:|...|:..:...||.:.:...:.|.|...::.|..:|
Zfish   969 EAKQHDPKVQAQKKRHQQQELIAELRRRQAKDHRPVYEGKDGTIEDIITVLKSVPFTAR 1027

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
form3	NP_001097527.1	Drf_FH3	48..309	CDD:461885	44/261 (17%)
		FH2	415..803	CDD:396655	83/391 (21%)
		PTZ00449	<1145..1465	CDD:185628
fmnl3	NP_001333083.1	Drf_GBD	23..268	CDD:461886	10/42 (24%)
		Drf_FH3	271..462	CDD:461885	40/243 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	520..561		22/50 (44%)
		FH2	580..945	CDD:396655	83/390 (21%)
		CwlO1	<941..>999	CDD:443091	16/57 (28%)