Protein Alignment form3 and Inf2

DIOPT Version :10

• Sequence 1: NP_001097527.1
• Gene: form3 / 3346238
• FlyBaseID: FBgn0053556
• Length: 1717
• Species: Drosophila melanogaster
• Sequence 2: XP_038969328.1
• Gene: Inf2 / 362790
• RGDID: 1308350
• Length: 1300
• Species: Rattus norvegicus
• Alignment Length: 1293
• Identity: 346/1293 - (26%)
• Similarity: 558/1293 - (43%)
• Gaps: 326/1293 - (25%)

  Fly     1 MDSRIGLDYIVENRDYIAKLGAALDTQNATVKKQVFELLSALCAYSPDGYARAIETLEFYKNLKK 65
            |:|:.|::||:.|:.|:.:|..||||.|..|||||||||:|||.|||:|:|..::.|:.||.:..
  Rat   134 MNSQQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHALTLDALDHYKMVCS 198

  Fly    66 QRYRFKIVINELELSSAAAHPPLDYQAALLAFINCVIISAATLQERIRIRNEFIGLKVLPLLNNL 130
            |:|||.:::|||..|.     .:.|...||:.||.:|:....|:.|.::|:|||||::|.:|..|
  Rat   199 QQYRFSVIMNELSDSD-----NVPYVVTLLSVINALILGPEDLRTRAQLRSEFIGLQLLDILTRL 258

  Fly   131 RLLEAGNVESSASPSPPPSLSSESASSATSPVSGSASTSVTPSPSPLHLQRRLTFCGSLSRYSCA 195
            |.||.
  Rat   259 RDLED------------------------------------------------------------ 263

  Fly   196 ALQLVQNLKKVAQSVGDIIVQLDVFVEQQECDEAQSLQAPDGINLNSHLDVFYAILRQVADTPQE 260
                           .|:::||:.|.|.:..||.:..:..||||:|||.:||.::..:|:.:|..
  Rat   264 ---------------ADLLIQLEAFEEAKAEDEEELQRVSDGINMNSHQEVFTSLFHKVSCSPAS 313

  Fly   261 VPFLNILQHLLRIDPKEPLSDIIWDTTERLVHRATLLESHEDSV-------RLL----------- 307
            ...|::||.|:.::|......::|:..|.||:||.||.|..::.       |||
  Rat   314 AQLLSVLQGLMHLEPAARSGQLLWEALENLVNRAVLLASDAEACTLEEVVERLLSIKGRPRPSPL 378

  Fly   308 ----------------------RTPSS-----QKFACQSCR------------------------ 321
                                  .||::     |......|:
  Rat   379 DKAHKSVQTNLGQNQGSSSQNTATPTAKVEGRQPVVASPCQHVGSIQSSSMDAAPQLAASPLPTP 443

  Fly   322 -----------------GSDASSPTRKPSQP------VGVSAKTTPPPPPPPMAP---------A 354
                             ||.|:||...|..|      .|....:.|||||||:.|         .
  Rat   444 PLSSSTPVLPPPPPPLPGSGATSPPAPPPPPPLPPPLPGSGTMSPPPPPPPPLPPPLPGLGAVSP 508

  Fly   355 APPPPPPPINGA---APPPPPPPMINGGALPPP------------PPPPSMQMASRPRTPDPLAA 404
            .|||||||:.|:   :||.|||.:.:...||||            ||||.:..|.:...|.||..
  Rat   509 PPPPPPPPLPGSRAVSPPAPPPSLPHSHPLPPPPPPPPLPGMCPVPPPPPLPTAGQVPPPPPLPG 573

  Fly   405 EAVATA------ILLPQQD-------TPA------PKAKMKTINWGKIPHNKVLGKQNIWSIVAS 450
            .:|.:.      |::.|.|       .|:      |..:||.:||.|:|.|....:.::|:.::|
  Rat   574 FSVPSVVGGVEEIIVAQVDHSLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVARERNSMWATLSS 638

  Fly   451 --NHQDSPMQDIDWNEMEGLFCLQTASAQGSPKLGRDGSQAAAGSNGCDTLDRKSKKESTEITLL 513
              ..:..|    |::.:|.||....|    .||   :.|.|.|            :||..|:|.|
  Rat   639 PCTAEVEP----DFSSIEQLFSFPMA----KPK---EPSAAPA------------RKEPKEVTFL 680

  Fly   514 DGKRSLNVNIFLKQFRTSNDDIIQLIRQGAHEEIGAERLRGLLKIMPEVDELDMLKGFNGDKARL 578
            |.|:|||:|||||||:.||:::..:|:.|...:...|.|:.|||::||..|::.|:.|..|:|:|
  Rat   681 DSKKSLNLNIFLKQFKCSNEEVTGMIQAGDTSKFDVEVLKQLLKLLPEKHEIENLRAFTEDRAKL 745

  Fly   579 GNAEKFLLQLLEVPNYKLRIESMLLKEEFAANVAYLEPCINSMLYAGDDLLNNKTLQEVLYMVVV 643
            .:|::|.:.||::|.|:||:|.|:|.|..|..:..:.|....:|.|.:.||.::.|.....:::.
  Rat   746 ASADQFYILLLDIPCYQLRVECMMLCEGTAIVLDMVRPKAQLVLTACESLLTSQRLPVFCQLILK 810

  Fly   644 AGNFLNSGGYAGNAAGVKLSSLQKLTDIRANKPGMNLIHFVALQAEKRNPELLQFTGQLSNLESA 708
            .|||||.|.:.|:|.|.|:|:|.|||:.::.:..:.|:|.|..:.||.:|:|||.:..|.:...|
  Rat   811 IGNFLNYGSHTGDADGFKISTLLKLTETKSQQSRVTLLHHVLEEVEKSHPDLLQLSRDLESPSQA 875

  Fly   709 SKTTSEQINNEINTLDGRIRRIARQIEQPATDVDIKEQMADFLQAAESELSVLQAGMKQVESMRL 773
            :....|.|::|.:....::....|::.....:|  ::|.|:.|||:......|......:|..:|
  Rat   876 AGIHLEIIHSEASANLKKLLEAERKVSSSIPEV--QKQYAERLQASIEASRALDKVFDAIEQKKL 938

  Fly   774 KMSEFFCDDAATFRLEECFKIFHNFCDKFKQAVKENERRQQQEQQATLRRKQREEQLARRARQIG 838
            :::::.|:|.....||:.|.....|.|.|.:|:|||:.|::|..:|..|::|..|:.|||.|.
  Rat   939 ELADYLCEDPQKLSLEDTFSTMKTFRDLFTRALKENKDRKEQMAKAEKRKQQLAEEEARRPRD-- 1001

  Fly   839 QAGTPV-----------------SDSEHSF--------LGDAIFDPRASPALSRRHLGSGEISNG 878
            :.|.||                 :|....|        .||.....|.:||...:.......||.
  Rat  1002 EDGKPVRKGPGKQEEVCVIDALLADIRKGFQLRKTARGRGDTEASGRVAPADPPKITEPATASNP 1066

  Fly   879 FIRLEQDGASP--DITPNGSLRRRRSRVLAEEDDLMEFLRSSTGPHHD--GHNSRERKAAYGSLD 939
            .....|..:.|  |.|..|.         .:..||::.:..|..|..:  |..|.||::
  Rat  1067 TQGTNQPASEPSSDTTAAGE---------PQGWDLVDAVTPSPQPTKEDGGPPSLERRS------ 1116

  Fly   940 RSWARRARSGSSSRKRPDLLN---------IDFGMDR-----ERASSPAPLLQQQQQNV--QERL 988
             ||...|   |......|:||         :..|.|:     |.:|:..|.:::..|:.  .|.|
  Rat  1117 -SWYVDA---SDFLAPEDILNTQPSEGAWPVTLGDDQALKPLEFSSNKPPGVERSHQDATDPEAL 1177

  Fly   989 ----QSPLASTAGTPTTAANTPTGSGSAIAQTPSNNEDAKPRISREWRQKIETWLQSNESDEKQN 1049
                ::...||:..|..|  |..|.|:.:.: |..:||.:   .......::|.|..:.|::...
  Rat  1178 WGVHRAEADSTSVRPEDA--TERGQGTHLPR-PGEDEDEE---DTALESALDTSLDRSFSEDAVT 1236

  Fly  1050 EEYRRKRRLVNANRRSLENETENERKLDPLPEEK------ILPSTTTATPTNTPTTTN 1101
            :. .....|.....| :...|...||..|...::      ..|:..:.||..||.:|:
  Rat  1237 DS-SGSGTLPRVQGR-ISKGTGKRRKKRPSRRQEGPGTSPCYPAGPSLTPAGTPGSTS 1292

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
form3	NP_001097527.1	Drf_FH3	48..309	CDD:461885	68/300 (23%)
		FH2	415..803	CDD:396655	123/402 (31%)
		PTZ00449	<1145..1465	CDD:185628
Inf2	XP_038969328.1	Drf_GBD	24..177	CDD:461886	24/42 (57%)
		Drf_FH3	181..366	CDD:461885	65/264 (25%)
		FH2	603..967	CDD:418645	120/388 (31%)
		WH2_INF2	1013..1042	CDD:409204	2/28 (7%)
		PRK07764	<1030..1217	CDD:236090	46/211 (22%)
		actin-binding sequence	1033..1036	CDD:409204	0/2 (0%)