Protein Alignment form3 and Diaph2

DIOPT Version :10

• Sequence 1: NP_001097527.1
• Gene: form3 / 3346238
• FlyBaseID: FBgn0053556
• Length: 1717
• Species: Drosophila melanogaster
• Sequence 2: NP_001414307.1
• Gene: Diaph2 / 317189
• RGDID: 1564399
• Length: 1101
• Species: Rattus norvegicus
• Alignment Length: 1023
• Identity: 243/1023 - (23%)
• Similarity: 418/1023 - (40%)
• Gaps: 265/1023 - (25%)

  Fly     1 MDSRIGLDYIVENRDYIAKLGAALDTQNATVKKQVFELLSALCAYSPD--------GYARAIETL 57
            |:::.||..|:.:...:..|..|:|.:...:..::.::|||:|....:        |...|.|
  Rat   250 MNNKFGLQRILGDERSLLLLARAIDPKQQNMMTEIVKILSAICIVGEENILDKLLGGITAAAE-- 312

  Fly    58 EFYKNLKKQRYRFKIVINELELSSAAAHPPLDYQAALLAFINCVIISAATLQERIRIRNEFI--G 120
                  :..|.||..::..||.:.|     |..|.|.:.|||.::.|...|..||.:||||:  |
  Rat   313 ------RNNRERFSPIVEGLENNEA-----LHLQVACMQFINALVTSPYDLDFRIHLRNEFLRCG 366

  Fly   121 LKVLPLLNNLRLLEAGNVESSASPSPPPSLSSESASSATSPVSGSASTSVTPSPSPLHLQRRLTF 185
            ||.:                      .|||..:...
  Rat   367 LKAM----------------------LPSLKEKEND----------------------------- 380

  Fly   186 CGSLSRYSCAALQLVQNLKKVAQSVGDIIVQLDVFVEQQECDEAQSLQAPDGI--NLNSHLDVFY 248
                                      ::.:||.||.|.:|.|..:.....:.|  .::...:||:
  Rat   381 --------------------------ELDIQLRVFEENKEDDLTELSHRLNDIRAEMDDMNEVFH 419

  Fly   249 AILRQVADTPQEVPFLNILQH--LLRID----P------KEPLSDII-----------------W 284
            .:...:.||..|...|:||||  |:|.|    |      :|.:|.|:                 :
  Rat   420 LLYNMLKDTAAEGYLLSILQHFLLIRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQRIDF 484

  Fly   285 DTT---ERLVHRATLLESHEDSVRLLRTPSSQKFACQSCRGSDASSPTRKPSQPV---------- 336
            |.|   :..|::|.:.||.:.::..     |:||..:.....:|.:..:|..:.:
  Rat   485 DFTHLIDACVNKAKVEESEQKAMEF-----SKKFDEEFTARQEAQAEIQKRDEKIKELESEIQQL 544

  Fly   337 ---GVSAKTTPPPPPPPMAPAA----PPPPPPPINGAAPPPPPPPMINGGALPPP--------PP 386
               |..:....||||||:..|.    |||||||:.|..||||||  :.|.|.|||        ||
  Rat   545 QAQGPGSAFPGPPPPPPLPGAGPCPPPPPPPPPLPGVGPPPPPP--LPGTAPPPPPLFGAPLLPP 607

  Fly   387 PPSMQMASRPRTPDPLAAEAVATAILLP----QQDTPAPKAKMKTINWGKI-PHNKVLGKQNIWS 446
            ||.   ...|..|.|         :.||    |:....|:..||.|||.|| |.:  |.:..:|.
  Rat   608 PPG---GITPSLPGP---------VELPYGMKQKKLYNPEVSMKRINWSKIEPRD--LSENCVWL 658

  Fly   447 IVASNHQDSPMQDIDWNEMEGLFCLQTASAQGSPKLGRDGSQAAAGSNGCDTLDRKSKKESTEIT 511
            .:.....::|          .||.....:.....|..|.|..:.....|      ..||:..|:.
  Rat   659 KLKEEKYENP----------DLFAKLALTFPSQMKGQRHGETSEENRIG------PQKKKMKELR 707

  Fly   512 LLDGKRSLNVNIFLKQFRTSNDDIIQLIRQGAHEEIGAERL-RGLLKIMPEVDELDMLKGFNGDK 575
            :||.|.:.|::|||..:|...::|..:|.: .:||:.:|.| :.|:|.:||.:.|..|.....:.
  Rat   708 ILDTKTAQNLSIFLGSYRMPYEEIKNIILE-VNEELLSEALIQNLVKYLPEQNVLRELAQLKNEY 771

  Fly   576 ARLGNAEKFLLQLLEVPNYKLRIESMLLKEEFAANVAYLEPCINSMLYAGDDLLNNKTLQEVLYM 640
            ..|...|:|.:.:..|...:.|:.|:|.|..|..:|..::|.|.::..|.::|..:::...:|.:
  Rat   772 DDLCEPEQFGVVMSTVNMLRPRLTSILFKLTFEEHVNNIKPSIIAVTLACEELKKSESFNRLLEL 836

  Fly   641 VVVAGNFLNSGGYAGNAAGVKLSSLQKLTDIRANKPGMNLIHFVALQAEKRNPELLQFTGQLSNL 705
            :::.||::|||.....:.|.|::.|.|:.|.::......|:||:|...::::.::|:|..:|.::
  Rat   837 ILLVGNYMNSGSRNAQSLGFKINFLCKIKDTKSADQKTTLLHFLAEICDEQHRDILKFPEELEHV 901

  Fly   706 ESASKTTSEQINNEINTLDGRIRRIARQIEQ--PATDVDIK--EQMADFLQAAESE---LSVLQA 763
            |||||.:::.:.:.:..::..|..:...|:.  .|..:..|  |:|..|.|.|..:   ||.:.:
  Rat   902 ESASKVSAQILKSNLVAMEQSILHLESNIKNFPKAESLHDKFVEKMMSFTQNAREQYDKLSTMHS 966

  Fly   764 GM-KQVESMRLKMSEFFCDDAATFRLEECFKIFHNFCDKFKQAVKENERRQQQEQQA----TLRR 823
            .| |..||    :.|:|..|.....:||.|...:.|...|.:|:|||.:|::.|:::    ..:.
  Rat   967 NMLKLYES----LGEYFIFDPNIVTIEEFFGDLNTFRTLFLEALKENHKRKEMEEKSRRAKLAKE 1027

  Fly   824 KQREEQLARRARQ-----IGQAG--TPVSDSEHSFLGDAIFDPRASPALSRRHLGSGEISNGFIR 881
            |..:|:|.|:.::     |.:.|  |.|.|:    |.:|:
  Rat  1028 KAEQEKLERQKKKKQLIDINKEGDETGVMDN----LLEAL------------------------- 1063

  Fly   882 LEQDGASPDITPNGSLRRRRSRVLAEEDDLMEFLRSSTGPHHDGHNSR 929
              |.||        :.|.||.|:....|:....|..|...|:....|:
  Rat  1064 --QSGA--------AFRDRRKRIPRNPDNRRPTLERSRSRHNGAMPSK 1101

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
form3	NP_001097527.1	Drf_FH3	48..309	CDD:461885	60/304 (20%)
		FH2	415..803	CDD:396655	101/397 (25%)
		PTZ00449	<1145..1465	CDD:185628
Diaph2	NP_001414307.1	None