Protein Alignment form3 and DAAM

DIOPT Version :10

• Sequence 1: NP_001097527.1
• Gene: form3 / 3346238
• FlyBaseID: FBgn0053556
• Length: 1717
• Species: Drosophila melanogaster
• Sequence 2: NP_001188522.1
• Gene: DAAM / 31075
• FlyBaseID: FBgn0025641
• Length: 1463
• Species: Drosophila melanogaster
• Alignment Length: 1057
• Identity: 259/1057 - (24%)
• Similarity: 456/1057 - (43%)
• Gaps: 201/1057 - (19%)

  Fly     1 MDSRIGLDYIVENRDYIAKLGAALDTQNATVKKQVFELLSALCAYSPDGYARAIETLEFYKNLKK 65
            |::.:|..:::.:...|..:..:|...|...|....|:|.|:|.. |.|:.:.::.:..::....
  Fly   505 MNNSMGRAHVLAHPTAIDTIARSLAADNIRTKIAALEILGAVCLV-PGGHRKVLQAMLHFQVFAT 568

  Fly    66 QRYRFKIVINELELSSAAAHPPLDYQAALLAFINCVI---ISAATLQERIRIRNEFIGLKVLPLL 127
            :|.||:.::|:|:.|:.|....::.:.||::|:|.|:   .....|:.|:.:|.||:.|.:.|::
  Fly   569 ERTRFQSIVNDLDRSTYAYRDNVNLKTALMSFVNAVLNYGPGQENLEFRLHLRYEFLMLGIQPVI 633

  Fly   128 NNLR---------------LLEAGNVESSASPSPPPSLSSESASSATSPVSGSASTSVTPS-PSP 176
            :.||               ::.|.:.:..|.......:.::||.|....:....|.|  |: |..
  Fly   634 DKLRTHENETLDRHLDFFEMVRAEDEKEFARRFKEEHVDTKSAGSMFELLRRKLSHS--PAYPHM 696

  Fly   177 LHLQRR---LTFCGSLSRYSCAALQLVQN--LKKVAQSVGDIIVQLDVFVEQQECDEAQSLQAPD 236
            |.|.:.   |.:.|..:.:.....::||.  |:...:...|:||..|...:|.:......:..||
  Fly   697 LSLLQHMLLLPYTGHCTEHWLLIDRVVQQIVLQVEQRPNSDLIVDPDDPEKQLKLAAESPVHDPD 761

  Fly   237 GINLNSHLDVFYAIL---------RQVADTPQEVPFLNILQHL--------LRIDPKEPLSDIIW 284
            ...|...:.....:|         |:.||..:...| ::...|        ||:..||.|...:.
  Fly   762 VAPLQIDVAKLVRLLVKEEQLTQARKRADELERENF-DVQSRLAKKEQELDLRMQEKEDLETGLA 825

  Fly   285 DTTERL----------VHRA------------TLLESHEDSVRLLR------TPSSQKFA-CQSC 320
            ...|||          |.||            .|:...::..||.|      .|..||.| ...|
  Fly   826 RMRERLEKESAQHSQAVQRAQTAEMRAEDLQHRLISEQQERARLERLVTEGSIPDDQKVAGLTGC 890

  Fly   321 RGSDASSPTRKPSQPVGVSAKTTPPPPPPPMAPAAPPPPPPPINGAAPPPPPP-PMINGGALPPP 384
            .|:                   ..|||.|||..|.||||||......|||||| |    ||   |
  Fly   891 NGA-------------------VSPPPAPPMLKAIPPPPPPMAPSMMPPPPPPCP----GA---P 929

  Fly   385 PPPPSMQMASRPRTPDPLAAEAVATAILLPQQDTPAPKAKMKTINWGKIPHNKVLGKQNIWSIVA 449
            ||||||.....|..|          .:.||:::.|.|...:|:.||.|:|..|:.|  .:||.:.
  Fly   930 PPPPSMAQTMAPAPP----------KVDLPKKNVPQPTNPLKSFNWSKLPDAKLQG--TVWSELD 982

  Fly   450 SNHQDSPMQDIDWNEMEGLFCLQTASAQGSPKLGRDGSQAAAGSNGCDTLDRKSKKESTEITLLD 514
            .:...:.|      |:|.:..|.:|       ..::|..|..||.....:..|:.|:.. ::::|
  Fly   983 ESKLYNNM------ELESIDKLFSA-------YQKNGVSATDGSYEDLRVTGKAAKQKV-LSVID 1033

  Fly   515 GKRSLNVNIFLKQFRTSNDDIIQ-LIRQGAHEEIGAERLRGLLKIMPEVDELDMLKGFNGDKARL 578
            |:|:.|..|.|.:.:.|:.:|.: ::...::|::..:.:..|||..|..:|..:|...:.|...|
  Fly  1034 GRRAQNCTILLSKLKMSDMEISKAILSMDSNEQLQLDMVEQLLKFTPSAEERALLDEHSEDIESL 1098

  Fly   579 GNAEKFLLQLLEVPNYKLRIESMLLKEEFAANVAYLEPCINSMLYAGDDLLNNKTLQEVLYMVVV 643
            ..|::||.::.::|:|:.|::|:..|:.|...:..|.|.|.|::.|..::..::.|:::|.:|:.
  Fly  1099 ARADRFLYEISKIPHYEQRLKSLHYKKRFMLTINDLVPRITSVMEASREVARSRRLRKLLELVLA 1163

  Fly   644 AGNFLNSGGYAGNAAGVKLSSLQKLTDIRAN-KPGMNLIHFVALQAEKRNPELLQFTGQLSNLES 707
            .||::|.|. .|||:|.:|:||.:|.|.::: ..|..|:|::....|::..:||:....:.::..
  Fly  1164 LGNYMNRGA-RGNASGFRLASLNRLADTKSSAAKGTTLLHYLVQVIERKFKDLLKLEDDIPHVRE 1227

  Fly   708 ASKTTSEQINNEINTLDGRIRRIARQIE-----QPATDVD-IKEQMADFLQAAESELSVLQAGMK 766
            |||.:..:::.:|..|...:..:||:||     .||...| ....|.:|...|....:.|:...:
  Fly  1228 ASKVSLGEMDKDIQMLRTGLADVAREIEFHRSSGPAQQGDRFLPVMREFHAQASVRFAELEDKFQ 1292

  Fly   767 QVESMRLKMSEFFCDDAATFRLEECFKIFHNFCDKFKQAVKENE--RRQQQEQQATLRRKQREEQ 829
            .:::...:....|.:|.:..:.:|.|.||.:|...|.:|..:||  ||:|:|::.  |.||..|.
  Fly  1293 DMKTRFDRAVRLFGEDGSVLQPDEFFGIFDSFLAAFAEARHDNESFRRRQEEEEK--RAKQEAEL 1355

  Fly   830 LARRARQIGQAGTPVSDSEHSFLGDAIFDPRASPALSRRHLG--SGEISNGFIRLEQDGASPDIT 892
            ..|...:..:.|...|.:                    |:||  ||. |||         .||..
  Fly  1356 KKRTIERKNKTGLMTSVA--------------------RNLGLKSGS-SNG---------DPDSP 1390

  Fly   893 PNGSLRRRRSRVLAEEDDLMEFLRS--------------------STGPHHDGHNSRERKAAYGS 937
            ..|...:      .|.|||:..||:                    :.|....||.|..|   :||
  Fly  1391 AKGGDNK------GEFDDLISALRTGDVFGEDMAKFKRSRKARVLNGGGSSTGHTSPPR---HGS 1446

  Fly   938 LDRSWARRARSGSSSRK 954
            |.|..:.|.|..:..|:
  Fly  1447 LQREESGRERERTVRRQ 1463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
form3	NP_001097527.1	Drf_FH3	48..309	CDD:461885	67/329 (20%)
		FH2	415..803	CDD:396655	98/395 (25%)
		PTZ00449	<1145..1465	CDD:185628
DAAM	NP_001188522.1	Drf_GBD	349..548	CDD:461886	9/42 (21%)
		Drf_FH3	551..737	CDD:461885	38/187 (20%)
		Smc	<765..>875	CDD:440809	22/110 (20%)
		FH2	950..1328	CDD:396655	98/394 (25%)