Protein Alignment form3 and Fhdc1

DIOPT Version :10

• Sequence 1: NP_001097527.1
• Gene: form3 / 3346238
• FlyBaseID: FBgn0053556
• Length: 1717
• Species: Drosophila melanogaster
• Sequence 2: NP_001099907.1
• Gene: Fhdc1 / 295161
• RGDID: 1311955
• Length: 1148
• Species: Rattus norvegicus
• Alignment Length: 1420
• Identity: 371/1420 - (26%)
• Similarity: 581/1420 - (40%)
• Gaps: 355/1420 - (25%)

  Fly   339 SAKTTPPPPPPPMAPAAPPPPPPPING----AAPPPPPPPMINGGALPPPPPPPSMQMASRPRTP 399
            |...:|.|||||     |||||.|.:|    .:||||.||.:.||. |.|||||.:..||
  Rat    30 SPSASPAPPPPP-----PPPPPCPHSGEGFPPSPPPPLPPPLPGGP-PVPPPPPGLPPAS----- 83

  Fly   400 DPLAAEAVATAILLPQQDTPAPKAKMKTINWGKIPHNKVLGKQNIWSIVASNHQDSPMQDIDWNE 464
                        .|....:...|.:|::..|..||..:|.||.|||::.|.....   ..||...
  Rat    84 ------------YLNGYSSLGKKKRMRSFFWKTIPEEQVRGKTNIWTLAAKQQHH---YQIDKKT 133

  Fly   465 MEGLFCLQTASAQGS-PKLGRDGSQAAAGSNGCDTLDRKSKKESTEITLLDGKRSLNVNIFLKQF 528
            :|.||..|..:::.| ||.|             ..|:...:....||.:||.|||:|:.||||||
  Rat   134 IEELFGQQEDTSKASLPKRG-------------GALNSSFRDAREEIAVLDAKRSMNIGIFLKQF 185

  Fly   529 RTSNDDIIQLIRQGAHEEIGAERLRGLLKIMPEVDELDMLKGFNGDKARLGNAEKFLLQLLEVPN 593
            :.|...|::.|.||..|..|:|.||.:||::||.:|:..||.||||.::|..|:.||..|::|||
  Rat   186 KKSPQSIVEDIHQGRSEHYGSETLREILKLLPESEEVKKLKTFNGDVSKLSLADSFLYCLIQVPN 250

  Fly   594 YKLRIESMLLKEEFAANVAYLEPCINSMLYAGDDLLNNKTLQEVLYMVVVAGNFLNSGGYAGNAA 658
            |.||||:|:||:||......|...|.::..|..:|:..:.|..:|::|:.|||.:|:|||||||.
  Rat   251 YSLRIEAMVLKKEFLPFCTSLYKDITTLRAAMKELMLCEELHSILHLVLQAGNIMNAGGYAGNAV 315

  Fly   659 GVKLSSLQKLTDIRANKPGMNLIHFVALQAEKRNPELLQFTGQLSNLESASKTTSEQINNEINTL 723
            |.|||||.||.|.:||||||||:||||.:|:|.|..||.|:.:|..::..|:.:.:.|..|:::|
  Rat   316 GFKLSSLLKLADTKANKPGMNLLHFVAQEAQKHNTILLNFSEKLQQVQETSRLSLDIIEAELHSL 380

  Fly   724 DGRIRRIARQIEQPATDVDIKEQMADFLQAAESELSVLQAGMKQVESMRLKMSEFFCDDAATFRL 788
            ..|.:.:...|::   |.::::||.||||.|..:|:.|:...::::.....:.:|||:|..|.:|
  Rat   381 FVRTKSLRENIQR---DQELRQQMEDFLQFAVEKLAELELWKRELQVEAHTLIDFFCEDKETMKL 442

  Fly   789 EECFKIFHNFCDKFKQAVKENERRQQQEQQATLRRKQREEQLARRARQIGQ-AGTPVSDSEHSFL 852
            :|||:||.:||.:|.:|||:|..|::||::...|.|:.|::  |.:...|: .|...|.||:..
  Rat   443 DECFQIFRDFCTRFNKAVKDNHDREEQERKQLQRLKELEQK--RHSWTTGELGGFGRSSSENDV- 504

  Fly   853 GDAIFDPRASPALSRRHLGSGEISNGFIRLEQDGASPDITPNGSLRRRRSRVLAEEDDLMEFLRS 917
                      ..|:::  |:.::.: |::...:  ||...|..:.|.|.|..::.:.:|:.||.|
  Rat   505 ----------QMLAKK--GTEDLPS-FLKPRPN--SPSYRPPNTRRSRLSLGISADRELLTFLES 554

  Fly   918 STGPHHDGHNSRERKAAYGSLDRSWARRARSGSSSRKRPDLLNIDFGMDRERASSPAPLLQQQQQ 982
            :|       :|.|....:.||.||..|:.|                           |.:...:.
  Rat   555 AT-------SSPEDPNKFNSLPRSSPRQTR---------------------------PTIAWMEP 585

  Fly   983 NVQERLQSPLASTAGTPTTAANTPTGSGSAIAQTP--SNNEDAKPRISREWRQKI-ETWLQSNES 1044
            ..||.                     .|......|  |.|::..|..:  |:..: .:||....|
  Rat   586 REQET---------------------HGPVFTHDPQASKNQEQTPHPA--WQNHLPPSWLGEPVS 627

  Fly  1045 DEKQNEEYRRKRRLVNANRRSLEN---ETENERKLDPLP---EEKILPSTTTATPTNTPTTTNPT 1103
            ........|...|     :||.|.   .|.....|.||.   .|..|.:..|.....:|.:...|
  Rat   628 PSPPAGRSRPSLR-----KRSSEPVGLGTAQSPPLLPLDLGIREHELVTGLTQFDLQSPKSLEET 687

  Fly  1104 NSTNRMDQESGKYQRVYADWKPSRTLEQTDVVANLQAIAD--AQPHDALRQHRRQRSQEQPSPIA 1166
            :            |....|:.|::          |..:.|  :||.||....|..:..:...  |
  Rat   688 S------------QLTLNDFCPTK----------LPPLGDKSSQPFDAGGDSRAPKDTDPRE--A 728

  Fly  1167 LQSIAEEDRRKSLIQKQGERDKSNERLQIYIRRSSSRELQPAKTEEHPLPPKSPKPQVSDDTFAS 1231
            |....|:||..|        |:.:....:.:..:.:.:..|...           ..|||.|..|
  Rat   729 LSPAGEDDRAIS--------DEPSSEALVSVVVTDTEDKDPGSL-----------LYVSDTTDCS 774

  Fly  1232 LL-------------SHHKTQNEMQGS---------SKDVDADNIETPPVSRRVIATPTTTVVTV 1274
            |.             ..|:.:.|..||         |..|.::...:||..   :..|.:|
  Rat   775 LTLDCSEGTDSRPGGDKHREEKEGDGSVSSGAGEAGSSQVSSNPASSPPGE---VPAPKST---- 832

  Fly  1275 SMTDKPKAATEEKINPA-----EQDAPGHFDRHALARRTRRYKRPTDYSSGNEEALTTSTAEAKT 1334
                        |..|:     ::|.|.. .:.|:|.:...:|                  ||..
  Rat   833 ------------KSEPSCQGGLQKDRPSR-GKDAMAPKRNSFK------------------EASV 866

  Fly  1335 SPSKPEPPAPEKSKQKERTINKLEKVGRHISSINQEDVREAIRNLKSPTGTPERPWSPPRDITPS 1399
            ..|||        ....|:.....|..|.::|...|.:|:.:...||..|.  .||..|
  Rat   867 GASKP--------VSARRSQGVAPKPVRTLNSSENEHMRKVVPISKSSRGA--GPWKRP------ 915

  Fly  1400 KLKLSASGHHELNDEGFEETQSLVSDTPSHGKGESTNSSCNEGVNETPARQRPMQKQKPTTTSIS 1464
                      ||.      :::...:|||....:.:..|...|.::|..| ||         .:|
  Rat   916 ----------ELT------SRATPRETPSSTDTQLSRRSSVRGTSDTSPR-RP---------QVS 954

  Fly  1465 QMGSRLADRLQQARM-KSSGSSGSAASKSQNQIPATQTATVKRSLSASRPLRMPNGQPLA----- 1523
            ..|:      ::.|: :||||.|                        .||.:.|..||.|
  Rat   955 GSGT------EEPRLPRSSGSIG------------------------GRPGKDPTLQPRASFRKP 989

  Fly  1524 SAAPLRSASTVRRSPQEQQVLAGVERSSSRNSLRSSRSSINSGASTQTVVRRLPAVQRAGATVSV 1588
            ||.|||:..  |:.|:|.:|       ||.||           ...::......|.|..||:.::
  Rat   990 SAKPLRNIP--RQKPEENKV-------SSPNS-----------RDPESPKEEPKAPQAPGASRAL 1034

  Fly  1589 DSSPS-KRPLAAQNLRPTQGRGVPASRSSSSGSSVGPSVILVRSKMSNTAPKSSIHGSTSFKENQ 1652
            ..:|| .|...|.:.|..:....||:|::....:|....:.|:|...::|.|.|.....:.....
  Rat  1035 PPTPSFARNTVASSSRSMRADAPPAARATGITRTVSQRQLRVKSGSEDSASKDSGTLKRASSARA 1099

  Fly  1653 SQSQPQSQSRMSAARSVVLVKNALNQQQQARMSANPSPQQRSTSSSRSVSSFMRP 1707
            |:..|:|....||.....|......::...|:         ..|...::...:||
  Rat  1100 SKKCPESAGGSSANVETPLKGRGTTERSSLRL---------KDSGQATLGRILRP 1145

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
form3	NP_001097527.1	Drf_FH3	48..309	CDD:461885
		FH2	415..803	CDD:396655	151/388 (39%)
		PTZ00449	<1145..1465	CDD:185628	64/346 (18%)
Fhdc1	NP_001099907.1	FH2	93..457	CDD:396655	151/382 (40%)
		PTZ00449	<559..760	CDD:185628	50/287 (17%)
		PHA03307	733..>1128	CDD:223039	108/543 (20%)