Protein Alignment form3 and fus1

DIOPT Version :10

• Sequence 1: NP_001097527.1
• Gene: form3 / 3346238
• FlyBaseID: FBgn0053556
• Length: 1717
• Species: Drosophila melanogaster
• Sequence 2: NP_594737.1
• Gene: fus1 / 2541741
• PomBaseID: SPAC20G4.02C
• Length: 1372
• Species: Schizosaccharomyces pombe
• Alignment Length: 1201
• Identity: 219/1201 - (18%)
• Similarity: 394/1201 - (32%)
• Gaps: 394/1201 - (32%)

  Fly     4 RIGLDYIVENRDYIAKLGAALDTQNATVKKQVFELLSALCAYS--PDGYARAIETLEFYKNLK-- 64
            :||.|:.:.|:..|..:...|.:....|:|...|||:.|| ||  |:|....::.::.:.|||
pombe   256 KIGTDFYLSNKYPIDSVVHCLLSTKLLVRKLAAELLTFLC-YSEKPNGINAIMKCMKNFANLKVE 319

  Fly    65 ------------KQRYRFKIVINELE-LSSAAAHP--PLDY---QAALL-AFINCVIISAATLQ- 109
                        |:....|:|..|.: |..||.|.  .::|   |..|: ||:..:....|.||
pombe   320 SMNVFDLWLSQWKRTLLEKVVTEEKKVLEEAALHDKITIEYIISQMLLINAFLENIPSKTALLQF 384

  Fly   110 -ERIRIRNEFIGLKVLPLLNNLRLLEAGNVESSASPSPPPSLSSESASSATSPVSGSASTSVTPS 173
             |.:||.|....|.:|..:|:..:|:                ..|......|..:.:....:..:
pombe   385 KESLRIGNFKSILLILKKINDEGVLK----------------QLEKCVKLVSLDTANEKHFLKHT 433

  Fly   174 P-SPLHLQRRLTFCGSLSRYSCAALQLVQNLKKVAQSVGD---IIVQLDVFVEQQECDEAQSLQA 234
            | |..|.....|...:.:.:.....:.::|..|:.:...:   ||..||..|...:.|:...
pombe   434 PNSAAHQSLLNTNMFNDANFEFMVKEHIKNFLKLLKEHNNPVRIIKLLDCLVLTLQADKGNG--- 495

  Fly   235 PDGINLNSHLDVFYAIL------------------------------------------------ 251
                |.|:.:|.||..|
pombe   496 ----NSNNDIDCFYKELKIGNEQGNNAPGYSSVTSGYGTTNSKKVVASYDNTDDNEYSVSKSELY 556

  Fly   252 ------------------RQVADTPQEVPFLNILQHLLRIDPKE--PLSDI----IWDTTERLVH 292
                              :.|..:..|....||...|..:.|.|  |.|..    |:...:.|:.
pombe   557 ATGDTNNTTNQGYENSERKYVESSKYETDLKNIFDCLCLLFPSEFDPQSSFSAEKIFSKLKHLLT 621

  Fly   293 RATLLESHEDS--VRLLRTPSS------QKFACQSCRGSDASSPTRKPSQPV----GVSAKTTPP 345
            |.......||:  :|||...||      |::...  :.:...:..|...|||    .|||..:|.
pombe   622 RTRDSYISEDTKILRLLNRSSSKLQDRDQEYLIS--KNNVNGNGNRDWVQPVNTTSSVSAFASPR 684

  Fly   346 PPPP----------------PMAPA------APPP--------------PPPPINGA-------- 366
            ..|.                .:|.|      :.|.              |...|..|
pombe   685 IKPKLLFQPNQDEKLKLCKLDLAKANSITLKSEPSSAVSTHSFEVHLSMPGTQIKSANLAEKMET 749

  Fly   367 -------------------------------------------------------APPPPPPPMI 376
                                                                   ||||.|
pombe   750 SKHKVFNPKRIDVVSDLPLDYRKSYYGRFSITDTKRFSKIENMRIKEVIDGNPFKAPPPAP---- 810

  Fly   377 NGGALPPPPPPPSMQMASRPRTPDPLAAEAVATAILLPQQ------------------------D 417
                ||||.||....|:|..:. :...::.....|::|:.                        :
pombe   811 ----LPPPAPPLPTAMSSLQKF-EKNDSQIFRKTIIIPENISIDDIFKFCSGSESEVYASKIPGE 870

  Fly   418 TPAPKAKMKTINWGK--IPHNKVLGKQNIWSIVASNHQDSPMQDIDWNEMEGLFCLQTASAQGSP 480
            ...|..::|.::|.:  :|..|.|     |:||.::..              |..|: .:|:|..
pombe   871 LCNPSKRLKQLHWKRLEVPFEKTL-----WNIVVADPY--------------LLTLK-LTAEGIF 915

  Fly   481 KLGRDGSQAAAGSNGC-----DTLDRKSKKESTEITLLDGKRSLNVNI----------FLKQFRT 530
            |...|          |     .|:..|..||.|....:|.::.:::.:          ..|:|..
pombe   916 KQLED----------CYPLREVTVSNKKVKEYTGFMPVDLQQMVSIRLHRFNSLTPIEIAKKFFH 970

  Fly   531 SNDDIIQLI-----RQGAHEEIGAERLRGLL-----KIMPEVDELDMLKGFNGDKARLGNAEKFL 585
            .:.||::|:     |:...:|...::|:..:     ::|...::|..|..|:         :.:.
pombe   971 CDHDIMELVDFFNDRKFFRQEGLKKQLKPYMSSRNEEVMEVSEKLLELSRFD---------QIYT 1026

  Fly   586 LQLLEVPN-YKLRIESMLLKEEFAANVAYLEPCINSMLYAGDDLLNNKTLQEVLYMVVVAGNFLN 649
            |.::::.. |:.|:.::.:|...|.|.......|..:..|..:|.::...:..|.:|:..|||:|
pombe  1027 LIVVDIDTYYEKRMAALKIKSFLANNFRDFRRQIRKLHCASLELKSSLHFKYFLNLVLHIGNFMN 1091

  Fly   650 SGGYAGNAAGVKLSSLQKLTDIRANKPGMNLIHFVALQAEKRNPELLQFTGQLSNLESASKTTSE 714
            ..  ...|.|.:|.||.:.:.|:.:|.|:.|:|.:........|:|..|...|..:...|:...|
pombe  1092 DA--PRRAKGYRLESLLRASMIKNDKTGLTLLHTIEKIVRTHFPQLEAFLVDLKAIPEISRFNLE 1154

  Fly   715 QINNEINTLDGRIRRIARQIEQPA---------TDVDIKEQMADFLQAAESELSVLQAGMKQVES 770
            |:..:.|.:..|::.:.:......         .|..|.|.|..::.:.:|.:..|.:.:.::::
pombe  1155 QLEQDCNDICERMKNVEKDFSNEGIFSNHKALHPDDHICEVMVPWIPSGKSMVDELNSDITELKT 1219

  Fly   771 MRLKMSEFFC---DDAATFRLEECFKIFHNFCD---KFKQAVKENERRQQQEQQATLR------- 822
             .||.:....   .|..|    ...:.|:|..:   ::|:|...|::.:::|:.|.||
pombe  1220 -TLKTTLLMYGENPDEPT----SSARFFNNLNEIILEYKKASTVNQKMEKEEELAFLRLQALKAS 1279

  Fly   823 ----------RKQREEQLARRARQIGQAGTPVSDSEHSFLGDAIFDPRASPALSRRHLGSGEISN 877
                      ..:.||..|.....|.|....:.|...|...|..                 |.|.
pombe  1280 VKSNNAENSGSSKNEEVSATMENLISQLQKGLCDDSLSNKTDCT-----------------ESSK 1327

  Fly   878 GFIRLEQDGASPDITPNGSLRRRRSRVLAEE 908
            ..|....:..:...|..||.::|::.||..|
pombe  1328 QTIETLMNYENDKQTLEGSNKKRQTVVLKAE 1358

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
form3	NP_001097527.1	Drf_FH3	48..309	CDD:461885	65/361 (18%)
		FH2	415..803	CDD:396655	80/454 (18%)
		PTZ00449	<1145..1465	CDD:185628
fus1	NP_594737.1	Drf_GBD	103..296	CDD:461886	13/40 (33%)
		FH2	868..1253	CDD:396655	80/430 (19%)