Protein Alignment form3 and DAAM2

DIOPT Version :10

• Sequence 1: NP_001097527.1
• Gene: form3 / 3346238
• FlyBaseID: FBgn0053556
• Length: 1717
• Species: Drosophila melanogaster
• Sequence 2: XP_006715102.3
• Gene: DAAM2 / 23500
• HGNCID: 18143
• Length: 1176
• Species: Homo sapiens
• Alignment Length: 953
• Identity: 228/953 - (23%)
• Similarity: 429/953 - (45%)
• Gaps: 171/953 - (17%)

  Fly     1 MDSRIGLDYIVENRDYIAKLGAALDTQNATVKKQVFELLSALCAYSPDGYARAIETLEFYKNLKK 65
            |::..|..:::...:.|:.:..:|.|:|:..|..|.|:|.|:|.. |.|:.:.::.:..|:....
Human   284 MNNSQGRAHVLAQPEAISTIAQSLRTENSKTKVAVLEILGAVCLV-PGGHKKVLQAMLHYQVYAA 347

  Fly    66 QRYRFKIVINELELSSAAAHPPLDYQAALLAFINCVIISAA---TLQERIRIRNEFIGLKVLPLL 127
            :|.||:.::|||:.|.......::.:.|:::|||.|:.:.|   .|:.|:.:|.||:.|.:.|::
Human   348 ERTRFQTLLNELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHLRYEFLMLGIQPVI 412

  Fly   128 NNLRLLEAGNVESSASPSPPPSLSSESASSATSPVSGSASTSVTPSPSPLHLQRRLTFCGSLSRY 192
            :.||..|...::....                       ...:..:...|.|.||.......::.
Human   413 DKLRQHENAILDKHLD-----------------------FFEMVRNEDDLELARRFDMVHIDTKS 454

  Fly   193 SCAALQLVQNLKKVAQSVGDIIVQLDVFVEQQECDEAQSLQAPDGIN--LNSHLDVFYAILRQVA 255
            :....:|:....|..::...::..|      ..|     ||.|...|  ......:...||:|:
Human   455 ASQMFELIHKKLKYTEAYPCLLSVL------HHC-----LQMPYKRNGGYFQQWQLLDRILQQI- 507

  Fly   256 DTPQEVPFLNILQHLLRIDPK-EPL-----SDII-----------W-DTTER-------LVHRAT 295
                      :||....:||. .||     .:|:           | |..|:       ||.|
Human   508 ----------VLQDERGVDPDLAPLENFNVKNIVNMLINENEVKQWRDQAEKFRKEHMELVSR-- 560

  Fly   296 LLESHE--------DSVRLLRT--PSSQKFACQS-----CRGSDASSPTRKPSQPVGVSAKTTPP 345
             ||..|        :...::||  ....|.|.:|     .||..|....:......|  ..::||
Human   561 -LERKERECETKTLEKEEMMRTLNKMKDKLARESQELRQARGQVAELVAQLSELSTG--PVSSPP 622

  Fly   346 PPPPPMAPAA-------PPPPPPPINGAAPPPPPPPMINGGALPPPPPPPSMQMA-SRPRTPDPL 402
            ||..|:..::       ||||||......|||||||:..||...||..||.:.|. ..|:.|.|
Human   623 PPGGPLTLSSSMTTNDLPPPPPPLPFACCPPPPPPPLPPGGPPTPPGAPPCLGMGLPLPQDPYP- 686

  Fly   403 AAEAVATAILLPQQDTPAPKAKMKTINWGKIPHNKVLGKQNIWSIVASNHQDSPMQ---DIDWNE 464
                 ::.:.|.::..|.|...:|:.||.|:...:|.|  .:|:.:      ..||   .:|..:
Human   687 -----SSDVPLRKKRVPQPSHPLKSFNWVKLNEERVPG--TVWNEI------DDMQVFRILDLED 738

  Fly   465 MEGLFCLQTASAQGSPKLGRDGSQAAAGSNGCDTLD-----RKSKKESTEITLLDGKRSLNVNIF 524
            .|.:|   :|..:....:.....|...||    |.|     ||.|    |::::||:|:.|..|.
Human   739 FEKMF---SAYQRHQELITNPSQQKELGS----TEDIYLASRKVK----ELSVIDGRRAQNCIIL 792

  Fly   525 LKQFRTSNDDIIQ-LIRQGAHEEIGAERLRGLLKIMPEVDELDMLKGFNGDKARLGNAEKFLLQL 588
            |.:.:.||::|.| :::....|::..:.|..|||.:||..::|:|:....:..|:..|::||.::
Human   793 LSKLKLSNEEIRQAILKMDEQEDLAKDMLEQLLKFIPEKSDIDLLEEHKHEIERMARADRFLYEM 857

  Fly   589 LEVPNYKLRIESMLLKEEFAANVAYLEPCINSMLYAGDDLLNNKTLQEVLYMVVVAGNFLNSGGY 653
            ..:.:|:.|::::..|::|...:|..:|.:.::|.|..:|:.:|.|:::|.:::..|||:|. |.
Human   858 SRIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLASRELVRSKRLRQMLEVILAIGNFMNK-GQ 921

  Fly   654 AGNAAGVKLSSLQKLTDIRAN-KPGMNLIHFVALQAEKRNPELLQFTGQLSNLESASKTTSEQIN 717
            .|.|.|.:::||.|:.|.::: ...::|:|::.:..||..|::|....:|.:|..|:|....::.
Human   922 RGGAYGFRVASLNKIADTKSSIDRNISLLHYLIMILEKHFPDILNMPSELQHLPEAAKVNLAELE 986

  Fly   718 NEINTLDGRIRRI-------ARQIEQPATD-VDIKEQMADFLQAAESELSVLQAGMKQVESMRLK 774
            .|:..|...:|.:       .||:.:|:.. |.:   |:||:..:....|.|:..:.:......|
Human   987 KEVGNLRRGLRAVEVELEYQRRQVREPSDKFVPV---MSDFITVSSFSFSELEDQLNEARDKFAK 1048

  Fly   775 MSEFFCDDAATFRLEECFKIFHNFCDKFKQAVKENE----RRQQQEQQATLR---RKQREEQLAR 832
            ....|.:..:..:.:|.|.||..|...|.:|.::.|    |::::|::|.:.   ::|||.:..:
Human  1049 ALMHFGEHDSKMQPDEFFGIFDTFLQAFSEARQDLEAMRRRKEEEERRARMEAMLKEQRERERWQ 1113

  Fly   833 RARQIGQAGTPVSDSEHSFLGDAIFDPRASPALSRRHLGSGEI 875
            |.|::..||:.:.:.     |:  ||...|.      |.|||:
Human  1114 RQRKVLAAGSSLEEG-----GE--FDDLVSA------LRSGEV 1143

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
form3	NP_001097527.1	Drf_FH3	48..309	CDD:461885	56/298 (19%)
		FH2	415..803	CDD:396655	100/405 (25%)
		PTZ00449	<1145..1465	CDD:185628
DAAM2	XP_006715102.3	Drf_GBD	140..327	CDD:461886	11/42 (26%)
		Drf_FH3	330..534	CDD:461885	47/248 (19%)
		FH2	694..1077	CDD:396655	100/405 (25%)