Protein Alignment form3 and DAAM1

DIOPT Version :10

• Sequence 1: NP_001097527.1
• Gene: form3 / 3346238
• FlyBaseID: FBgn0053556
• Length: 1717
• Species: Drosophila melanogaster
• Sequence 2: NP_055807.1
• Gene: DAAM1 / 23002
• HGNCID: 18142
• Length: 1078
• Species: Homo sapiens
• Alignment Length: 992
• Identity: 242/992 - (24%)
• Similarity: 444/992 - (44%)
• Gaps: 170/992 - (17%)

  Fly     1 MDSRIGLDYIVENRDYIAKLGAALDTQNATVKKQVFELLSALCAYSPDGYARAIETLEFYKNLKK 65
            |::..|..:::.:.:.|..:..:|.|:|...|..|.|:|.|:|.. |.|:.:.::.:..|:....
Human   189 MNNSQGRAHVLAHSESINVIAQSLSTENIKTKVAVLEILGAVCLV-PGGHKKVLQAMLHYQKYAS 252

  Fly    66 QRYRFKIVINELELSSAAAHPPLDYQAALLAFINCVIISAA---TLQERIRIRNEFIGLKVLPLL 127
            :|.||:.:||:|:.|:......:..:.|:::|||.|:...|   :|..|:.:|.||:.|.:.|::
Human   253 ERTRFQTLINDLDKSTGRYRDEVSLKTAIMSFINAVLSQGAGVESLDFRLHLRYEFLMLGIQPVI 317

  Fly   128 NNLRLLEAGNV------------ESSASPSPPPSLSSESASSATSPVSGSASTSVTPSPSPLHLQ 180
            :.||..|...:            |.....:....|......|||. :.......:|.|.:..|..
Human   318 DKLREHENSTLDRHLDFFEMLRNEDELEFAKRFELVHIDTKSATQ-MFELTRKRLTHSEAYPHFM 381

  Fly   181 RRLTFC--------GSLSRYSCAALQLVQNLKKVAQSVGDIIVQLDVFVEQQECDEAQSLQAPDG 237
            ..|..|        |:..:|.....:::|          .|::|.|            ..|.||.
Human   382 SILHHCLQMPYKRSGNTVQYWLLLDRIIQ----------QIVIQND------------KGQDPDS 424

  Fly   238 INL-NSHLDVFYAIL---RQVADTPQEVPFL----NILQHLL---------RIDPKEPLSDIIWD 285
            ..| |.::.....:|   .:|....::...:    |.||..|         :...||.:...:..
Human   425 TPLENFNIKNVVRMLVNENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNK 489

  Fly   286 TTERLVHRATLLESHEDSVRLLRT---PSSQKFACQSCRGSDASSPTRKPSQPVGVSAKTTPPPP 347
            ..|:|....|..:..:..|..|..   ..|::..|.|..|..:      |..|.|         |
Human   490 MKEKLEKETTEHKQVKQQVADLTAQLHELSRRAVCASIPGGPS------PGAPGG---------P 539

  Fly   348 PPPMAPAA--PPPPPPPINGAAPPPPPPPMINGGALPPPPPPPSMQMASRPRTPDPLAAEAVATA 410
            .|...|.:  |||||||:.|...||||||:..||..|||.|||...:...|..|..||
Human   540 FPSSVPGSLLPPPPPPPLPGGMLPPPPPPLPPGGPPPPPGPPPLGAIMPPPGAPMGLA------- 597

  Fly   411 ILLPQQDTPAPKAKMKTINWGKIPHNKVLGKQNIWSIVASNHQDSPM-QDIDWNEMEGLFCLQTA 474
              |.::..|.|...:|:.||.|:|.||:.|  .:|:.:    .|:.: :.:|..::|..|  ...
Human   598 --LKKKSIPQPTNALKSFNWSKLPENKLEG--TVWTEI----DDTKVFKILDLEDLERTF--SAY 652

  Fly   475 SAQGSPKLGRDGSQAAAGSNGCDTLDRKSKKESTEITLLDGKRSLNVNIFLKQFRTSNDDIIQ-L 538
            ..|....:..:..|..|.:.. |||..|.|.:  |::::||:|:.|.||.|.:.:.|||:|.: :
Human   653 QRQQDFFVNSNSKQKEADAID-DTLSSKLKVK--ELSVIDGRRAQNCNILLSRLKLSNDEIKRAI 714

  Fly   539 IRQGAHEEIGAERLRGLLKIMPEVDELDMLKGFNGDKARLGNAEKFLLQLLEVPNYKLRIESMLL 603
            :.....|::..:.|..|||.:||..::|:|:....:..|:..|::||.::..:.:|:.|::|:..
Human   715 LTMDEQEDLPKDMLEQLLKFVPEKSDIDLLEEHKHELDRMAKADRFLFEMSRINHYQQRLQSLYF 779

  Fly   604 KEEFAANVAYLEPCINSMLYAGDDLLNNKTLQEVLYMVVVAGNFLNSGGYAGNAAGVKLSSLQKL 668
            |::||..||.::|.:.::....:::..:..|:::|.:|:..||::|. |..|||.|.|:|||.|:
Human   780 KKKFAERVAEVKPKVEAIRSGSEEVFRSGALKQLLEVVLAFGNYMNK-GQRGNAYGFKISSLNKI 843

  Fly   669 TDIRAN-KPGMNLIHFVALQAEKRNPELLQFTGQLSNLESASKTTSEQINNEINTLDGRIRRIAR 732
            .|.::: ...:.|:|::....|.:.|.:|....:|.::..|:|....:::.||:||...::.:..
Human   844 ADTKSSIDKNITLLHYLITIVENKYPSVLNLNEELRDIPQAAKVNMTELDKEISTLRSGLKAVET 908

  Fly   733 QIE----QPATDVD-IKEQMADFLQAAESELSVLQAGMKQVESMRLKMSEFFCDDAATFRLEECF 792
            ::|    ||....| ....::.|:..|....|.::..:.:.:.:..|..:.|.::|...:.:|.|
Human   909 ELEYQKSQPPQPGDKFVSVVSQFITVASFSFSDVEDLLAEAKDLFTKAVKHFGEEAGKIQPDEFF 973

  Fly   793 KIFHNFCDKFKQAVKENE--RRQQQEQ------QATLRRKQREEQLARRARQIGQAGTPVSDSEH 849
            .||..|.....:|.:|||  |::::|:      :|.|:.::..|:..|:|::         :||.
Human   974 GIFDQFLQAVSEAKQENENMRKKKEEEERRARMEAQLKEQRERERKMRKAKE---------NSEE 1029

  Fly   850 SFLGDAIFDPRASPALSRRHLGSGEISNGFIRLEQDGASPDITPNGSLRRRRSRVLAEEDDLMEF 914
            |  |:  ||...|.      |.|||:.:           .|::   .|:|.|.|:..:..|
Human  1030 S--GE--FDDLVSA------LRSGEVFD-----------KDLS---KLKRNRKRITNQMTD---- 1066

  Fly   915 LRSSTGPHHDGHNSRER 931
                        :||||
Human  1067 ------------SSRER 1071

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
form3	NP_001097527.1	Drf_FH3	48..309	CDD:461885	59/300 (20%)
		FH2	415..803	CDD:396655	101/395 (26%)
		PTZ00449	<1145..1465	CDD:185628
DAAM1	NP_055807.1	Drf_GBD	45..232	CDD:461886	11/42 (26%)
		Drf_FH3	235..439	CDD:461885	46/226 (20%)
		PRK12704	444..>513	CDD:237177	12/68 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	456..480		4/23 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	524..585		31/75 (41%)
		FH2	600..984	CDD:396655	101/395 (26%)
		Actin-binding	693..702		4/8 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	987..1034		14/59 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1055..1078		8/33 (24%)