Protein Alignment form3 and frl-1

DIOPT Version :10

• Sequence 1: NP_001097527.1
• Gene: form3 / 3346238
• FlyBaseID: FBgn0053556
• Length: 1717
• Species: Drosophila melanogaster
• Sequence 2: NP_497505.4
• Gene: frl-1 / 175346
• WormBaseID: WBGene00021698
• Length: 1200
• Species: Caenorhabditis elegans
• Alignment Length: 1042
• Identity: 227/1042 - (21%)
• Similarity: 375/1042 - (35%)
• Gaps: 295/1042 - (28%)

  Fly     1 MDSRIGLDYIVENRDYIAKLGAALDTQNATVKKQVFELLSALC------AYSPDGYARAIETLEF 59
            |:::.|...:..:.|.|..:..::..||...|..|.::||::|      ....|.:.|      |
 Worm   320 MNNKQGFQQVFADTDAIYCIVRSILHQNLRTKTLVLQMLSSICWVQGGQELVSDAFDR------F 378

  Fly    60 YKNLKKQRYRFKIVINELELSSAAAHPPLDYQAALLAFINCVIISAATLQERIRIRNEFIGLKVL 124
            .|:.::.| ||      ..|....:||| ::....|:             ..::....|:.:..|
 Worm   379 EKDFREPR-RF------WTLMQFVSHPP-EFHVEFLS-------------SAVQFFYYFVNVDDL 422

  Fly   125 PLLNNLRLLEAGNVESSASPSPPPSLSSESASSATSPVSGSASTSVTPSPSPLHLQRRLTFCGSL 189
                |.|                                             :|||..:|..| |
 Worm   423 ----NFR---------------------------------------------VHLQYEMTLLG-L 437

  Fly   190 SRYSCAALQLVQNLKKVAQSVGDIIVQLDVFVEQQECDEAQSLQAP---DGINLNSHLDVFYAIL 251
            .:|                        :|:..| .|.||.|.....   :||::...||
 Worm   438 DKY------------------------IDMMAE-CESDELQERMISYQNNGIDVQQLLD------ 471

  Fly   252 RQVADTPQEVPFLNILQHLL--------RIDPKEP------------LSDII------------- 283
                |:.|:...|:..:.:|        ||...|.            |.|::
 Worm   472 ----DSNQKTELLDENERILSQLSQAKERIQEVEAKWITDKAALDRRLFDLVKERESMEKEYVEE 532

  Fly   284 ---WDTT------------ERLVHRATLLESHEDSVRL-LRTPSSQKFACQSCRGSDASSPTRKP 332
               |..|            :||..:...||:.:..::. |:....|:.|..:...:...||...|
 Worm   533 KGSWTKTMNEKDRQAREERKRLEQKIGELEAIQKQMQAGLQVQQQQQAAAAAAAAAAQKSPPTPP 597

  Fly   333 SQPVGV------SAKTTPP----------PPPPPMAP--AA-------PPPPPPP----INGAAP 368
            ....|.      |....||          |||||:|.  ||       |||||||    ::||.|
 Worm   598 PPAPGPHKEQRRSTSKDPPRPAPPPVSSIPPPPPIAGLLAANGTNVPIPPPPPPPLPQNLSGAPP 662

  Fly   369 PPPPPPMINGGALPPPPPPPSMQMASRPRTPDPLAAEAVATAILLPQQDTPAPKAKMKTINWGKI 433
            ||||||.:.||. |||||||...|.  |.:.|....:.:...           |.|:..:||..:
 Worm   663 PPPPPPPMLGGP-PPPPPPPGGLMG--PASNDAKTIKKIYQT-----------KNKLPQLNWTAM 713

  Fly   434 ----PHNKVLGKQNIWSIVASNHQDSPMQDIDWNEMEGLFCL-------------QTASAQGSPK 481
                ..|.|..|.|...|:         :.:|::::|.:|.|             |:...|.||
 Worm   714 KPMQAKNTVFEKLNDELII---------EKLDFSKLEEMFKLAQPTLGLAEPKSEQSVIGQVSP- 768

  Fly   482 LGRDGSQAAAGSNGCDTLDRKSKKESTEITLLDGKRSLNVNIFLKQFRTSNDDIIQLIRQGAHEE 546
               ..:.:|||::..    ||:       ||||.||..||.|..::.......|:..:.|.....
 Worm   769 ---GSTTSAAGTSSA----RKN-------TLLDTKRLQNVAITRRKVAMDAKSIMAAVHQLNLSA 819

  Fly   547 IGAERLRGLLKIMPEVDELDMLKG-----FNGDKARLGNAEKFLLQLLEVPNYKLRIESMLLKEE 606
            :.||::..|.:|:|..:|..:..|     .......|...:.|:..|.|:...:.::..|.:..|
 Worm   820 LSAEKVDILSRILPTDEERKLYAGKKTTESENSMENLSEDDNFVAALCEIERLEHKLAVMRVMSE 884

  Fly   607 FAANVAYLEPCINSMLYAGDDLLNNKTLQEVLYMVVVAGNFLNSGGYAGNAAGVKLSSLQKLTDI 671
            |..:...|||....:..|.......:....||.:::..||::|| |..|.|.|.|||||..|..:
 Worm   885 FDESAGLLEPQFTHVTAASKCAREAQLFHGVLEVILAFGNYMNS-GKRGGAYGFKLSSLDSLAIL 948

  Fly   672 RANKP-GMNLIHFVALQAEKRNPELLQFTGQLSNLESASKTTSEQINNEINTLDGRIRRIARQIE 735
            :|... .:.|:|.:..:.||..|.|..|:.||..::.|:....:.:..::..|....:...:  |
 Worm   949 KAPADRSLTLLHMIVAEIEKNLPHLKTFSEQLKFVDKATSVQWDSVQTDMKELAAGFKMAEK--E 1011

  Fly   736 QPATDVDIKEQMADFLQAAESELSVLQAGMKQVESMRLKMSEFFCDDAATFRLEECFKIFHNFCD 800
            |.....|..|.::.|..:.:.:::.|:...:...|......||:.::..:......|:...:|..
 Worm  1012 QELKGTDCPEALSTFTASRKQKMADLEQAFQLAASSFKDCCEFYGENEKSTSPTVFFQKLAHFVQ 1076

  Fly   801 KFKQAVKENERRQQQEQQATLRRKQREEQLARRARQIGQAGTPVSDSEHSFL-------GDAIFD 858
            .:::...|||.:...|       |:|:|:..||||......:..|:.:...:       |..|..
 Worm  1077 NYQKCRGENEAKAALE-------KRRQEEAERRARVASTKSSASSEQDQLMMELAEKVGGMGIGK 1134

  Fly   859 -PRASPALSRRHLGSGE-ISNGFIRLEQDGA----------SPDITPNGSLR---RRRSRVLAEE 908
             ||.....:|...|..| :.||   |:..|.          ||...|.||..   ..::||::.|
 Worm  1135 RPRGKIDSTRMDHGDFEKLMNG---LKHTGGTTPNRRKMSKSPSPAPRGSAPPPVAPKTRVVSVE 1196

  Fly   909 DD 910
            .|
 Worm  1197 RD 1198

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
form3	NP_001097527.1	Drf_FH3	48..309	CDD:461885	49/312 (16%)
		FH2	415..803	CDD:396655	90/410 (22%)
		PTZ00449	<1145..1465	CDD:185628
frl-1	NP_497505.4	Drf_GBD	94..362	CDD:461886	10/41 (24%)
		Drf_FH3	366..561	CDD:461885	46/306 (15%)
		FH2	695..1079	CDD:396655	90/421 (21%)