Protein Alignment form3 and DIAPH2

DIOPT Version :10

• Sequence 1: NP_001097527.1
• Gene: form3 / 3346238
• FlyBaseID: FBgn0053556
• Length: 1717
• Species: Drosophila melanogaster
• Sequence 2: NP_006720.1
• Gene: DIAPH2 / 1730
• HGNCID: 2877
• Length: 1101
• Species: Homo sapiens
• Alignment Length: 1018
• Identity: 232/1018 - (22%)
• Similarity: 413/1018 - (40%)
• Gaps: 246/1018 - (24%)

  Fly     1 MDSRIGLDYIVENRDYIAKLGAALDTQNATVKKQVFELLSALCAYSP----DGYARAIETLEFYK 61
            |:::.||..|:.:...:..|..|:|.:...:..::.::|||:|....    |....||.|.....
Human   241 MNNKFGLQRILGDERSLLLLARAIDPKQPNMMTEIVKILSAICIVGEENILDKLLGAITTAAERN 305

  Fly    62 NLKKQRYRFKIVINELELSSAAAHPPLDYQAALLAFINCVIISAATLQERIRIRNEFI--GLKVL 124
            |    |.||..::..||...|     |..|.|.:.|||.::.|...|..||.:||||:  |||.
Human   306 N----RERFSPIVEGLENQEA-----LQLQVACMQFINALVTSPYELDFRIHLRNEFLRSGLKT- 360

  Fly   125 PLLNNLRLLEAGNVESSASPSPPPSLSSESASSATSPVSGSASTSVTPSPSPLHLQRRLTFCGSL 189
                                                                             
Human   361 ----------------------------------------------------------------- 360

  Fly   190 SRYSCAALQLVQNLKKVAQSVGDIIVQLDVFVEQQECDEAQSLQAPDGI--NLNSHLDVFYAILR 252
                     ::.:||:  :...::.:||.||.|.:|.|..:.....:.|  .::...:|::.:..
Human   361 ---------MLPDLKE--KENDELDIQLKVFDENKEDDLTELSHRLNDIRAEMDDMNEVYHLLYN 414

  Fly   253 QVADTPQEVPFLNILQHLLRI----------------------------DP----KEPLSDIIWD 285
            .:.||..|..||:||||.|.|                            ||    ::.|...:..
Human   415 MLKDTAAENYFLSILQHFLLIRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQRLDIDLTH 479

  Fly   286 TTERLVHRATLLESHEDSVRLLRTPSSQKFACQSCRGSDASSPTRKPSQPV-------------- 336
            ..:..|::|.:.||.:.:...     |:||..:.....:|.:..:|..:.:
Human   480 LIDSCVNKAKVEESEQKAAEF-----SKKFDEEFTARQEAQAELQKRDEKIKELEAEIQQLRTQA 539

  Fly   337 -------GVSAKTTPP------PPPPPMAPAAP-----PPPPPPING--AAPPPPPPPMINGGAL 381
                   |:......|      |||||.||..|     ||||||:.|  ..|||||||::.||
Human   540 QVLSSSSGIPGPPAAPPLPGVGPPPPPPAPPLPGGAPLPPPPPPLPGMMGIPPPPPPPLLFGG-- 602

  Fly   382 PPPPPPPSMQMASRPRTPDPLAAEAVATAILLP----QQDTPAPKAKMKTINWGKIPHNKVLGKQ 442
             ||||||   :...|..|        ..::.||    |:....|:..||.|||.||...: |.:.
Human   603 -PPPPPP---LGGVPPPP--------GISLNLPYGMKQKKMYKPEVSMKRINWSKIEPTE-LSEN 654

  Fly   443 NIWSIVASNHQDSPMQDIDWNEMEGLFCLQTASAQGSPKLGRDGSQAAAGSNGCDTLDRK----S 503
            ..|..|..:..::|          .||.          ||..:.:.........:.|:.|    :
Human   655 CFWLRVKEDKFENP----------DLFA----------KLALNFATQIKVQKNAEALEEKKTGPT 699

  Fly   504 KKESTEITLLDGKRSLNVNIFLKQFRTSNDDIIQLIRQGAHEEIGAERLRGLLKIMPEVDELDML 568
            ||:..|:.:||.|.:.|::|||..:|...:||..:|.:...:.:....::.|:|.:||...|:.|
Human   700 KKKVKELRILDPKTAQNLSIFLGSYRMPYEDIRNVILEVNEDMLSEALIQNLVKHLPEQKILNEL 764

  Fly   569 KGFNGDKARLGNAEKFLLQLLEVPNYKLRIESMLLKEEFAANVAYLEPCINSMLYAGDDLLNNKT 633
            .....:...|...|:|.:.:..|...:.|:.|:|.|..|..::..::|.|.::..|.::|..:::
Human   765 AELKNEYDDLCEPEQFGVVMSSVKMLQPRLSSILFKLTFEEHINNIKPSIIAVTLACEELKKSES 829

  Fly   634 LQEVLYMVVVAGNFLNSGGYAGNAAGVKLSSLQKLTDIRANKPGMNLIHFVALQAEKRNPELLQF 698
            ...:|.:|::.||::|||.....:.|.|::.|.|:.|.::......|:||:|...|::..::|:|
Human   830 FNRLLELVLLVGNYMNSGSRNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEKYRDILKF 894

  Fly   699 TGQLSNLESASKTTSEQINNEINTLDGRIRRIARQIE---QPATDVD-IKEQMADFLQAAESELS 759
            ..:|.::|||||.:::.:.:.:.:::.:|..:.|.|:   |.....| ..|:|..|.:.|..:..
Human   895 PEELEHVESASKVSAQILKSNLASMEQQIVHLERDIKKFPQAENQHDKFVEKMTSFTKTAREQYE 959

  Fly   760 VLQAGMKQVESMRLKMSEFFCDDAATFRLEECFKIFHNFCDKFKQAVKENERRQQQEQ---QATL 821
            .|......:..:...:.|:|..|:.|..:||.|...:||...|.:||:||.:|::.|:   :|.|
Human   960 KLSTMHNNMMKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRREMEEKTRRAKL 1024

  Fly   822 RRKQREEQLARRARQIGQAGTPVSDSEHSFLGDAIFDPRASPALSRRHLGSGEISNGFIRLEQDG 886
            .:::.|::...|.::..|                :.|      :::....:|.:.| .:...|.|
Human  1025 AKEKAEQEKLERQKKKKQ----------------LID------INKEGDETGVMDN-LLEALQSG 1066

  Fly   887 ASPDITPNGSLRRRRSRVLAEEDDLMEFLRSSTGPHHDGHNSR 929
            |        :.|.||.|:....|:....|..|...|:...:|:
Human  1067 A--------AFRDRRKRIPRNPDNRRVPLERSRSRHNGAISSK 1101

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
form3	NP_001097527.1	Drf_FH3	48..309	CDD:461885	57/296 (19%)
		FH2	415..803	CDD:396655	96/395 (24%)
		PTZ00449	<1145..1465	CDD:185628
DIAPH2	NP_006720.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44
		Drf_GBD	101..284	CDD:461886	10/42 (24%)
		Drf_FH3	292..480	CDD:461885	53/273 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	536..594		19/57 (33%)
		FH2	628..1002	CDD:396655	96/394 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1010..1048		8/59 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1070..1101		8/30 (27%)