Protein Alignment form3 and DIAPH1

DIOPT Version :10

• Sequence 1: NP_001097527.1
• Gene: form3 / 3346238
• FlyBaseID: FBgn0053556
• Length: 1717
• Species: Drosophila melanogaster
• Sequence 2: NP_005210.3
• Gene: DIAPH1 / 1729
• HGNCID: 2876
• Length: 1272
• Species: Homo sapiens
• Alignment Length: 1100
• Identity: 257/1100 - (23%)
• Similarity: 421/1100 - (38%)
• Gaps: 336/1100 - (30%)

  Fly     1 MDSRIGLDYIVENRDYIAKLGAALDTQNATVKKQVFELLSALC--AYSPDGYARAIETLEFYKNL 63
            |:::.|:..::|..:.|..|..|:|.....:.....:||||||  ....|...|.:|.:.....:
Human   225 MNNKFGIKTMLETEEGILLLVRAMDPAVPNMMIDAAKLLSALCILPQPEDMNERVLEAMTERAEM 289

  Fly    64 KKQRYRFKIVINELELSSAAAHPPLDYQAALLAFINCVIISAATLQERIRIRNEFIGLKVLPLLN 128
            .:.. ||:.:::.|:..:..|     .:...|..||.:|..|..|..|:.||:|
Human   290 DEVE-RFQPLLDGLKSGTTIA-----LKVGCLQLINALITPAEELDFRVHIRSE----------- 337

  Fly   129 NLRLLEAGNVESSASPSPPPSLSSESASSATSPVSGSASTSVTPSPSPLHLQRRLTFCGSLSRYS 193
               |:..|                                        ||
Human   338 ---LMRLG----------------------------------------LH--------------- 344

  Fly   194 CAALQLVQNLKKVAQSVGDIIVQLDVFVEQQECDEAQSLQAPDGINLNSHLD-----------VF 247
                |::|:|:::...  |:.|||:||.||.|         .|..:|...||           ||
Human   345 ----QVLQDLREIENE--DMRVQLNVFDEQGE---------EDSYDLKGRLDDIRMEMDDFNEVF 394

  Fly   248 YAILRQVADTPQEVPFLNILQHLLRI----------------------------DPK-------- 276
            ..:|..|.|:..|..||:||||||.:                            ||.
Human   395 QILLNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECISQIVLHKNGADPDFKCRHLQI 459

  Fly   277 --EPLSDIIWDTT--ERLVHRATLLES---------HEDSVRLLRTPSSQKFACQSCRG------ 322
              |.|.|.:.|.|  |:...:|..||.         ||..|.:.:..|..:...|..:|
Human   460 EIEGLIDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQVEMKKMESDFEQKLQDLQGEKDALH 524

  Fly   323 -------------------------------SDA----------------SSPTRKPSQPV---- 336
                                           .||                |.|:|.|..|.
Human   525 SEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLP 589

  Fly   337 GVSA-----------KTTPPPPPPPMAPAAPPP--------------------PPPPINGAA--- 367
            |.|.           .|||||||||  |..|||                    ||||::|.|
Human   590 GDSGTIIPPPPAPGDSTTPPPPPPP--PPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIP 652

  Fly   368 -PPP-------------------PPPPMINGGALPPPPPPPSMQMASRPRTPDPLAAEA------ 406
             |||                   ||||.:.|.|..||||||....|..|..|.||..||
Human   653 PPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPP 717

  Fly   407 ---------------------------------------VATAILLPQQDTP----APKAKMKTI 428
                                                   |..|.:||...||    .|:.:::..
Human   718 PPLPGGPGIPPPPPFPGGPGIPPPPPGMGMPPPPPFGFGVPAAPVLPFGLTPKKLYKPEVQLRRP 782

  Fly   429 NWGKIPHNKVLGKQNIWSIVASNHQDSPMQDIDWNEMEGLFCLQTASAQGSPKLGRDGSQAAAGS 493
            ||.|:.... |.:...|:.|..:..::       ||:.....| |.|||...      |:|....
Human   783 NWSKLVAED-LSQDCFWTKVKEDRFEN-------NELFAKLTL-TFSAQTKT------SKAKKDQ 832

  Fly   494 NGCDTLDRKSKKESTEITLLDGKRSLNVNIFLKQFRTSNDDIIQLIRQGAHEEIGAERLRGLLKI 558
            .|.:......||:..|:.:||.|.:.|::|||..||....:|..:|.:.....:....::.|:|.
Human   833 EGGEEKKSVQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQ 897

  Fly   559 MPEVDELDMLKGFNGDKARLGNAEKFLLQLLEVPNYKLRIESMLLKEEFAANVAYLEPCINSMLY 623
            |||.::|.||.....:...|..:|:|.:.:..||..:.|:.::|.|.:|:..|..::|.|.|:..
Human   898 MPEPEQLKMLSELKDEYDDLAESEQFGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTA 962

  Fly   624 AGDDLLNNKTLQEVLYMVVVAGNFLNSGGYAGNAAGVKLSSLQKLTDIRANKPGMNLIHFVALQA 688
            |.::|..:::...:|.:.::.||::|:|.....|.|..:|.|.||.|.::....|.|:||:|...
Human   963 ACEELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLCKLRDTKSTDQKMTLLHFLAELC 1027

  Fly   689 EKRNPELLQFTGQLSNLESASKTTSEQINNEINTLDGRIRRIARQIEQ--PATDVDIK--EQMAD 749
            |...|::|:|..:|:::|.||:.::|.:...::.:..:|..:.|.::.  .|||...|  |:|..
Human  1028 ENDYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEKMTS 1092

  Fly   750 FLQAAESELSVLQAGMKQVESMRLKMSEFFCDDAATFRLEECFKIFHNFCDKFKQAVKENERRQQ 814
            |::.|:.:.:.|:.....:|::..::.|:|..|.....:||.|...|||.:.|.||||||::|::
Human  1093 FVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHNFRNMFLQAVKENQKRRE 1157

  Fly   815 QEQ---QATLRRKQREEQLARRARQIGQAGTPVSDSEHSFLGDAIFDPRASPALSRRHLG 871
            .|:   :|.|.:::.|::...:.::..|.....::.:.:.:.|::.:...|.|..||..|
Human  1158 TEEKMRRAKLAKEKAEKERLEKQQKREQLIDMNAEGDETGVMDSLLEALQSGAAFRRKRG 1217

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
form3	NP_001097527.1	Drf_FH3	48..309	CDD:461885	65/320 (20%)
		FH2	415..803	CDD:396655	103/395 (26%)
		PTZ00449	<1145..1465	CDD:185628
DIAPH1	NP_005210.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..84
		Drf_GBD	84..268	CDD:461886	12/42 (29%)
		Drf_FH3	274..464	CDD:461885	54/279 (19%)
		SMC_prok_B	<429..>570	CDD:274008	19/140 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	573..755		48/183 (26%)
		Drf_FH1	590..>704	CDD:461881	38/115 (33%)
		FH2	769..1145	CDD:396655	102/390 (26%)