Protein Alignment form3 and FAM47B

DIOPT Version :10

• Sequence 1: NP_001097527.1
• Gene: form3 / 3346238
• FlyBaseID: FBgn0053556
• Length: 1717
• Species: Drosophila melanogaster
• Sequence 2: NP_689844.2
• Gene: FAM47B / 170062
• HGNCID: 26659
• Length: 645
• Species: Homo sapiens
• Alignment Length: 620
• Identity: 135/620 - (21%)
• Similarity: 187/620 - (30%)
• Gaps: 183/620 - (29%)

  Fly  1015 QTPSN------NEDAKPRISREWRQKIETWLQSNESDEKQNEEYRRKRRLVNANRRSLENETENE 1073
            |:|.:      :|...|:||          |:..::|.|.     ||::|:  .:.:|.:|
Human    63 QSPEDTLVCRRDEFLLPKIS----------LRGPQADRKS-----RKKKLL--KKAALFSE---- 106

  Fly  1074 RKLDPL-PEEKILPSTTTA-TPTNTPTTTNPTNSTNRMDQESGKYQRVYADWKPSRTLEQTDVVA 1136
              |.|: |..|.......| ..|..|....|...   .|.......:|.....|.|.||  |..|
Human   107 --LSPVQPARKAFVEEVEAQLMTKHPLAMYPNLG---KDMPPDLLLQVLKQLDPERKLE--DAWA 164

  Fly  1137 NLQAIADAQPHDALRQHRRQRSQEQPSPIALQSIAEEDRRKSLIQKQGERDKSNERLQIYIRRSS 1201
            ..:|              |:::.|.|:........|...|..      |...|..|.|:.....|
Human   165 RCEA--------------REKTTEVPTESGKYPCGESCPRPP------ETPVSRLRPQLPKTPVS 209

  Fly  1202 SRELQPAKTEEHPLPPKSPKPQVSDDTFASLLSHHKTQNEMQGSSKDVDADNIETPP---VSRRV 1263
            ||..:|.||....|.|:.||.:||        |.|....|.:.|...||      ||   ||...
Human   210 SRRPEPPKTRVSSLRPEPPKTRVS--------SLHPEPPETRASHLRVD------PPETGVSHLC 260

  Fly  1264 IATPTTTVVTVSMTDKPKAATEEKINPAEQDAPGHFDRHALARRTRRYKRPTDYSSGNEEALTTS 1328
            ...|.|.|.:|........|:.....|.|                      |..|..:.|...|.
Human   261 PEPPKTLVSSVHPEPPDTGASHLCPEPPE----------------------TRVSHLHPEPPETG 303

  Fly  1329 TAEAKTSPSK-------PEPPAPEKS------KQKERTINKLEKVGRHISSINQEDVREAIRNLK 1380
            .:..:..|||       ||||....|      ....|..:.|.:|.:..|....||.|......:
Human   304 VSHLRPEPSKTQVSSLCPEPPEAGVSHLCLEPPNTHRVSSFLLQVLKLDSEKKLEDARARCEGQE 368

  Fly  1381 SPTGTPERP-----W-----------------------------SPPR-----DITPSKLKLSAS 1406
            ..|....:|     |                             .||:     .:.|...|..||
Human   369 MTTEELTKPGKYHFWESCPRPFESRMPHLRLVLPITRRMASLCLKPPKTRRVSSLCPEPTKTGAS 433

  Fly  1407 GHHELNDEGFEETQSLVSDTPSHGKGESTNSSCNE-------GVNE---------TPARQRPMQK 1455
            ...||..|....|...|||:...   ..|:....:       ||||         ||..:...|.
Human   434 HLKELFQEDTPSTMECVSDSLQR---RHTSRKLRDFKWAGDLGVNEESISSLFDFTPECRTTDQD 495

  Fly  1456 QKPTTTSISQMGSRL--------ADRLQQARMKSSGSSGSAASKSQNQIPATQTATVKRSLSASR 1512
            ||  ....::..|||        .|.::..|:|.......||..|.    :.|...::.......
Human   496 QK--IKKANECASRLMYGMELDDMDEVEFLRIKYWDRRRRAAPHSY----SAQRGRIRYGPWYFE 554

  Fly  1513 PLRMPNGQPLASAAPLRSASTVRRSPQEQQVLAGV 1547
            |   ..|:.|.|..||.....|...|.|..:|.|:
Human   555 P---KLGKKLRSDEPLIDPKPVLEKPDEPDILDGL 586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
form3	NP_001097527.1	Drf_FH3	48..309	CDD:461885
		FH2	415..803	CDD:396655
		PTZ00449	<1145..1465	CDD:185628	83/390 (21%)
FAM47B	NP_689844.2	FAM47	1..257	CDD:405345	60/255 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		PTZ00449	<167..377	CDD:185628	59/265 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	168..321		46/208 (22%)